Jolkinolide B inhibits proliferation or migration and promotes apoptosis of MCF-7 or BT-474 breast cancer cells by downregulating the PI3K-Akt pathway DOI Creative Commons
Yang Wang, Shiyang Shen, Lei Liu

et al.

Journal of Ethnopharmacology, Journal Year: 2021, Volume and Issue: 282, P. 114581 - 114581

Published: Aug. 28, 2021

The diterpenoids extracted from Euphorbia kansui S.L. Liou ex S.B.Ho, fischeriana Steud. have good antitumor effects. Jolkinolide B has anti-breast cancer effect, but it is unclear whether different therapeutic effects between luminal A subtype and breast cancer.This study investigated the therapeutic, important targets pathways cancer.We used bioinformatics to predict biological process molecular mechanism of in treating two types cancer. Then, vitro, cultured MCF-7 cells BT-474 were divided into control group, PI3K inhibitor + group group. CCK-8 assay, Flow cytometric analysis Transwell cell migration assay was detect proliferation, apoptosis, each respectively. ELISA measure content Akt phosphorylated (p-Akt) lysis buffer.Compared cancer, had more targets, processes KEGG when significantly prolonged survival time patients. Compared proliferation absorbance value (A value) number kinds decreased (P < 0.01, n = 6), apoptotic increased 6). In addition, compared cells, stimulated with p-Akt protein levels lines all especially by B.Jolkinolide regulates subtypes through PI3K-Akt, EGFR other pathways. significant effect on experiments verified that inhibited activity downregulating PI3K-Akt pathway.

Language: Английский

Organic Sonosensitizers for Sonodynamic Therapy: From Small Molecules and Nanoparticles toward Clinical Development DOI
Dong Li, Yang Yang, Dengfeng Li

et al.

Small, Journal Year: 2021, Volume and Issue: 17(42)

Published: Aug. 4, 2021

Abstract Sonodynamic therapy (SDT) is a novel noninvasive therapeutic modality that combines low‐intensity ultrasound and sonosensitizers. Versus photo‐mediated therapy, SDT has the advantages of deeper tissue penetration, high accuracy, less side effects. Sonosensitizers are critical for efficacy during organic sonosensitizers important because their clear structure, easy monitoring, evaluation drug metabolism, clinical transformation. Notably, nanotechnology can be used in field to overcome inherent obstacles achieve sustainable innovation. This review introduces small molecule sonosensitizers, nano translation by providing ideas references design so as promote its transformation applications future.

Language: Английский

Citations

179
Oxidative cell death in cancer: mechanisms and therapeutic opportunities DOI Creative Commons
Xiaoqin An, Wenfeng Yu, Jinbao Liu

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(8)

Published: Aug. 1, 2024

Abstract Reactive oxygen species (ROS) are highly reactive oxygen-containing molecules generated as natural byproducts during cellular processes, including metabolism. Under normal conditions, ROS play crucial roles in diverse functions, cell signaling and immune responses. However, a disturbance the balance between production antioxidant defenses can lead to an excessive buildup, causing oxidative stress. This stress damages essential components, lipids, proteins, DNA, potentially culminating death. form of death take various forms, such ferroptosis, apoptosis, necroptosis, pyroptosis, paraptosis, parthanatos, oxeiptosis, each displaying distinct genetic, biochemical, characteristics. The investigation holds promise for development pharmacological agents that used prevent tumorigenesis or treat established cancer. Specifically, targeting key SLC7A11, GCLC, GPX4, TXN, TXNRD, represents emerging approach inducing cancer cells. review provides comprehensive summary recent progress, opportunities, challenges therapy.

Language: Английский

Citations

64
Paraptosis: a unique cell death mode for targeting cancer DOI Creative Commons

Sweata Hanson,

Aiswarya Dharan,

P. V. Jinsha

et al.

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 15, 2023

Programmed cell death (PCD) is the universal process that maintains cellular homeostasis and regulates all living systems' development, health disease. Out of all, apoptosis one major PCDs was found to play a crucial role in many disease conditions, including cancer. The cancer cells acquire ability escape apoptotic death, thereby increasing their resistance towards current therapies. This issue has led need search for alternate forms programmed mechanisms. Paraptosis an alternative pathway characterized by vacuolation damage endoplasmic reticulum mitochondria. Many natural compounds metallic complexes have been reported induce paraptosis lines. Since morphological biochemical features are much different from other PCDs, it understand modulators governing it. In this review, we highlighted factors trigger specific mediating pathway. Recent findings include inducing anti-tumour T-cell immunity immunogenic responses against A significant played also scaled its importance knowing mechanism. study xenograft mice, zebrafish model, 3D cultures, novel paraptosis-based prognostic model low-grade glioma patients broad aspect potential involvement field therapy. co-occurrence modes with photodynamic therapy combinatorial treatments tumour microenvironment summarized here. Finally, growth, challenges, future perspectives research discussed review. Understanding unique PCD would help develop combat chemo-resistance various

Language: Английский

Citations

57
Thioredoxin (Trx): A redox target and modulator of cellular senescence and aging-related diseases DOI Creative Commons
Bowen Yang, Yumeng Lin, Yibo Huang

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103032 - 103032

Published: Jan. 21, 2024

Thioredoxin (Trx) is a compact redox-regulatory protein that modulates cellular redox state by reducing oxidized proteins. Trx exhibits dual functionality as an antioxidant and cofactor for diverse enzymes transcription factors, thereby exerting influence over their activity function. has emerged pivotal biomarker various diseases, particularly those associated with oxidative stress, inflammation, aging. Recent clinical investigations have underscored the significance of in disease diagnosis, treatment, mechanistic elucidation. Despite its paramount importance, intricate interplay between senescence-a condition characterized irreversible growth arrest induced multiple aging stimuli-remains inadequately understood. In this review, our objective to present comprehensive up-to-date overview structure function Trx, involvement signaling pathways senescence, association age-related well potential therapeutic target. Our review aims elucidate novel extensive role senescence while highlighting implications diseases.

Language: Английский

Citations

21
Natural products targeting the MAPK-signaling pathway in cancer: overview DOI Creative Commons

Aiwen Shi,

Li Liu, Shuang Li

et al.

Journal of Cancer Research and Clinical Oncology, Journal Year: 2024, Volume and Issue: 150(1)

Published: Jan. 1, 2024

Abstract Purpose This article summarizes natural products that target the MAPK-signaling pathway in cancer therapy. The classification, chemical structures, and anti-cancer mechanisms of these are elucidated, comprehensive information is provided on their potential use Methods Using PubMed database, we searched for keywords, including “tumor”, “cancer”, “natural product”, “phytochemistry”, “plant components”, “MAPK-signaling pathway”. We also screened compounds with well-defined structures targeting have effects. used Kingdraw software Adobe Photoshop to draw compound structural diagrams. Results A total 131 papers were searched, from which 85 selected. These clear treatment mainly related pathway. Examples include eupatilin, carvacrol, oridonin, sophoridine, diosgenin, juglone. components classified as flavonoids, phenols, terpenoids, alkaloids, steroidal saponins, quinones. Conclusions Certain MAPK inhibitors been clinical treatment. However, feedback has not promising because genomic instability, drug resistance, side Natural few effects, good medicinal efficacy, a wide range sources, individual heterogeneity biological activity, capable treating disease multiple targets. characteristics make drugs

Language: Английский

Citations

20
Cannabidiol activates MAPK pathway to induce apoptosis, paraptosis, and autophagy in colorectal cancer cells DOI
Na Young Kim, Chakrabhavi Dhananjaya Mohan, Gautam Sethi

et al.

Journal of Cellular Biochemistry, Journal Year: 2024, Volume and Issue: 125(4)

Published: Feb. 15, 2024

Abstract Mitogen‐activated protein kinase (MAPK) activation by natural compounds is known to be involved in the induction of apoptosis, paraptosis, and autophagy. Cannabidiol (CBD), a bioactive compound found Cannabis sativa , endowed with many pharmacological activities. We investigated cytotoxic effect CBD panel colorectal cancer (CRC) cells (HT‐29, SW480, HCT‐116, HCT‐15). induced significant cytotoxicity as evidenced results MTT assay, live‐dead flow cytometric analysis. Since displayed against CRC cells, we examined on decreased expression antiapoptotic proteins increased Annexin‐V‐positive well TUNEL‐positive suggesting that induces apoptosis. ATF4 (activating transcription factor 4) CHOP (CCAAT/enhancer‐binding homologous protein), elevated endoplasmic reticulum stress, enhanced reactive oxygen species levels indicating also promotes paraptosis. Atg7, phospho‐Beclin‐1, LC3 accelerates Since, MAPK pathway common cascade regulation autophagy, JNK, p38, ERK pathways. activated all forms inhibition these reverted observed effects. Our findings implied could induce cell death activating autophagy through pathway.

Language: Английский

Citations

20
Euphorbiaditerpenoids: isolation, structure, bioactivity, biosynthesis, and synthesis (2013–2021) DOI
Zha‐Jun Zhan,

Shen Li,

W. L. Alexis Chu

et al.

Natural Product Reports, Journal Year: 2022, Volume and Issue: 39(11), P. 2132 - 2174

Published: Jan. 1, 2022

Covering: 2013 to 2021As the characteristic metabolites of Euphorbia plants, diterpenoids have always been a hot topic in related science communities due their intriguing structures and broad bioactivities. In this review, we intent provide an in-depth extensive coverage reported from end 2021, including 997 new 78 known ones with latest progress. Multiple aspects will be summarized, occurrences, chemical structures, bioactivities, syntheses, which structure-activity relationship biosynthesis class discussed for first time.

Language: Английский

Citations

62
Paraptosis: a non-classical paradigm of cell death for cancer therapy DOI

Chuncao Xu,

Yifan Lin,

Mu-yang Huang

et al.

Acta Pharmacologica Sinica, Journal Year: 2023, Volume and Issue: 45(2), P. 223 - 237

Published: Sept. 15, 2023

Language: Английский

Citations

28
Targeting paraptosis in cancer: opportunities and challenges DOI Open Access
Fangquan Chen, Hu Tang,

Xiutao Cai

et al.

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: 31(3), P. 349 - 363

Published: Jan. 4, 2024

Language: Английский

Citations

13
Natural products and derivatives in renal, urothelial and testicular cancers: Targeting signaling pathways and therapeutic potential DOI
Dengxiong Li, Jie Wang,

Zhouting Tuo

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 127, P. 155503 - 155503

Published: Feb. 28, 2024

Language: Английский

Citations

11