Bacterial carrier-mediated drug delivery systems: a promising strategy in cancer therapy DOI Creative Commons
Shaomin Yan, Yu Gan, Huizhe Xu

et al.

Frontiers in Bioengineering and Biotechnology, Journal Year: 2025, Volume and Issue: 12

Published: Jan. 8, 2025

Cancer is a major killer threatening modern human health and leading cause of death worldwide. Due to the heterogeneity complexity cancer, traditional treatments have limited effectiveness. To address this problem, an increasing number researchers medical professionals are working develop new ways treat cancer. Bacteria chemotaxis that can target colonize tumor tissue, as well activate anti-tumor immune responses, which makes them ideal for biomedical applications. With rapid development nanomedicine synthetic biology technologies, bacteria extensively used carriers drug delivery tumors, holds promise overcoming limitations conventional cancer treatment regimens. This paper summarizes examples anti-cancer drugs delivered by bacterial carriers, their strengths weaknesses. Further, we emphasize carrier systems in clinical translation.

Language: Английский

Stimuli-activatable nanomedicine meets cancer theranostics DOI Creative Commons
Haonan Li, Feng Yue, Qiang Luo

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

Citations

147
Manganese-phenolic nanoadjuvant combines sonodynamic therapy with cGAS-STING activation for enhanced cancer immunotherapy DOI
Hao Tian, Guohao Wang, Wei Sang

et al.

Nano Today, Journal Year: 2022, Volume and Issue: 43, P. 101405 - 101405

Published: Jan. 25, 2022

Language: Английский

Citations

129
Harnessing Nanomaterials for Cancer Sonodynamic Immunotherapy DOI
Shuang Liang, Jianjun Yao, Dan Liu

et al.

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: March 7, 2023

Abstract Immunotherapy has made remarkable strides in cancer therapy over the past decade. However, such emerging still suffers from low response rates and immune‐related adverse events. Various strategies have been developed to overcome these serious challenges. Therein, sonodynamic (SDT), as a non‐invasive treatment, received ever‐increasing attention especially treatment of deep‐seated tumors. Significantly, SDT can effectively induce immunogenic cell death trigger systemic anti‐tumor immune response, termed immunotherapy. The rapid development nanotechnology revolutionized effects with robust induction. As result, more innovative nanosonosensitizers synergistic modalities are established superior efficacy safe profile. In this review, recent advances immunotherapy summarized particular emphasis on how be explored harness for amplifying response. Moreover, current challenges field prospects its clinical translation also presented. It is anticipated that review provide rational guidance facilitate nanomaterials‐assisted immunotherapy, helping pave way next‐generation eventually achieve durable patients.

Language: Английский

Citations

126
Recent advances on modulation of H2O2 in tumor microenvironment for enhanced cancer therapeutic efficacy DOI

Zhaoyou Chu,

Juan Yang, Zheng Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 481, P. 215049 - 215049

Published: Feb. 9, 2023

Language: Английский

Citations

125
Macrophage-Targeted Sonodynamic/Photothermal Synergistic Therapy for Preventing Atherosclerotic Plaque Progression Using CuS/TiO2 Heterostructured Nanosheets DOI
Zhengyu Cao, Guotao Yuan, Lingli Zeng

et al.

ACS Nano, Journal Year: 2022, Volume and Issue: 16(7), P. 10608 - 10622

Published: June 27, 2022

Sonodynamic therapy (SDT) and photothermal (PTT) are two effective strategies for the treatment of atherosclerotic plaques. However, low yield reactive oxygen species (ROS) conventional organic sonosensitizers biosafety hyperthermia limit therapeutic efficacy SDT PTT. Herein, we report copper sulfide/titanium oxide heterostructure nanosheets modified with hyaluronic acid (HA) PEG (HA-HNSs) low-intensity sonodynamic mild-photothermal synergistic early CuS/TiO2 (HNSs) show high electron–hole separation efficiency superior performance, because it has surface energy crystal facets as well a narrow band. Moreover, HNSs exhibit intense absorbance in NIR-II region, which endows excellent performance. With further modification HA, HA-HNSs can selectively target intraplaque proinflammatory macrophages through CD44-HA interaction. Because reduces expression heat shock protein 90 PTT facilitates sonocatalytic process, combination based on could synergistically induce macrophage apoptosis. More importantly, prevents progression plaque by removing lesional mitigating inflammation. Taken together, this work provides macrophage-targeting sonodynamic/photothermal therapy, is an translational clinical intervention

Language: Английский

Citations

115
Recent developments of sonodynamic therapy in antibacterial application DOI
Ruhao Wang, Qianwen Liu, Ang Gao

et al.

Nanoscale, Journal Year: 2022, Volume and Issue: 14(36), P. 12999 - 13017

Published: Jan. 1, 2022

This review summarizes the currently available sonosensitizers for antibacterial SDT and digs into innovative biotechnologies to improve efficiency.

Language: Английский

Citations

81
Cancer cell membrane-coated C-TiO2 hollow nanoshells for combined sonodynamic and hypoxia-activated chemotherapy DOI
Shipeng Ning, Xingliang Dai,

Weiwei Tang

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 152, P. 562 - 574

Published: Sept. 5, 2022

Language: Английский

Citations

73
Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions DOI Creative Commons
Haiyan Gao,

Zhiping Cao,

Huanhuan Liu

et al.

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1974 - 2014

Published: Jan. 1, 2023

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to activate Fenton reaction or Fenton-like generate strong oxidative hydroxyl radicals tumor-specific treatment. It highly selective and safe, without depth limitation of tissue penetration, shows its potential as a new green therapeutic method with great clinical application. However, catalytic efficiency reagents involved in severely affected by inherent microenvironmental limitations tumors strict reaction-dependent conditions. With increasing application nanotechnology medical field, combined therapies based on different types functional nanomaterials have opened up avenues development next-generation CDT-enhanced system. This review will comprehensively exemplify representative results CDT other antitumor such chemotherapy, phototherapy, sonodynamic therapy, radiation magnetic hyperthermia immunotherapy, starvation gas gene oncosis combination thereof improving from hundreds latest literature, introduce strategies ingenious design nanomedicines regulations enhance further summarize challenges future perspective CDT-based multimodal anticancer therapy.

Language: Английский

Citations

64
Cell membrane biomimetic nanomedicines for cancer phototherapy DOI Creative Commons
Min Chen, Yun Sun, Huiyu Liu

et al.

Deleted Journal, Journal Year: 2023, Volume and Issue: 1(2)

Published: Feb. 21, 2023

Abstract Phototherapy, mainly including photothermal therapy (PTT) and photodynamic (PDT), can kill cancer cells by generating heat or reactive oxygen species, which has the advantages of being minimally invasive, high efficiency, low toxicity. However, traditional phototherapeutic agents face challenges such as poor tumor targeting, susceptibility to passive immune clearance, suboptimal biocompatibility, limit their clinical application. Recently, cell membrane biomimetic technology endows with unique biological functions, promoted escape, prolonged in vivo circulation time, improved enhanced anti‐tumor efficacy. In addition, phototherapy mediated (CCM) membrane‐modified promote broad immunity. this review, we deeply analyze mechanisms PTT PDT, systematically discuss synthesis strategies functions nanomaterials, focus on progress based nanomaterials synergistic therapies chemotherapy, radiotherapy, immunotherapy, sonodynamic therapy. Finally, address opportunities future prospects field phototherapy. This comprehensive review is expected provide insights into promoting translation agents.

Language: Английский

Citations

61
GSH‐Activated Porphyrin Sonosensitizer Prodrug for Fluorescence Imaging‐Guided Cancer Sonodynamic Therapy DOI

Caiting Deng,

Meichen Zheng,

Shupeng Han

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(32)

Published: May 5, 2023

Sonodynamic therapy (SDT), which uses ultrasound to trigger a sonosensitizer generate reactive oxygen species (ROS), is promising form of cancer with outstanding tissue penetration depth. However, the may inevitably spread surrounding healthy beyond tumor, resulting in undesired side effects under an stimulus. Herein, as glutathione (GSH) overexpressed tumor microenvironment, GSH-activatable prodrug was designed by attaching quencher tetraphydroxy porphyrin for therapy. The exhibited poor fluorescence and low ROS generation capacity irradiation but it can be activated GSH simultaneously switch on emission site. Compared non-quenched sonosensitizer, significantly higher tumor/healthy organ ratios, due specific activation tumor. Finally, efficient growth inhibition irradiation, further demonstrating its promise GSH-activated highly effective treatment.

Language: Английский

Citations

55