Bioorganic & Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 127, P. 118241 - 118241
Published: May 15, 2025
Language: Английский
Nature Reviews Drug Discovery, Journal Year: 2024, Volume and Issue: 23(8), P. 583 - 606
Published: July 9, 2024
Language: Английский
Citations
137
MedComm, Journal Year: 2023, Volume and Issue: 4(3)
Published: May 17, 2023
Organoids are three-dimensional (3D) miniaturized versions of organs or tissues that derived from cells with stem potential and can self-organize differentiate into 3D cell masses, recapitulating the morphology functions their in vivo counterparts. Organoid culture is an emerging technology, organoids various tissues, such as brain, lung, heart, liver, kidney, have been generated. Compared traditional bidimensional culture, organoid systems unique advantage conserving parental gene expression mutation characteristics, well long-term maintenance function biological characteristics vitro. All these features open up new opportunities for drug discovery, large-scale screening, precision medicine. Another major application disease modeling, especially hereditary diseases difficult to model vitro modeled by combining genome editing technologies. Herein, we introduce development current advances technology field. We focus on applications basic biology clinical research, also highlight limitations future perspectives. hope this review provide a valuable reference developments organoids.
Language: Английский
Citations
106
Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(1), P. 18 - 38
Published: Jan. 24, 2024
Language: Английский
Citations
59
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, Journal Year: 2024, Volume and Issue: 1879(6), P. 189175 - 189175
Published: Aug. 31, 2024
Language: Английский
Citations
27
Cells, Journal Year: 2024, Volume and Issue: 13(5), P. 441 - 441
Published: March 2, 2024
Oxidative stress refers to the imbalance between production of reactive oxygen species (ROS) and endogenous antioxidant defense system. Its involvement in cell senescence, apoptosis, series diseases has been demonstrated. Advances carcinogenic research have revealed oxidative as a pivotal pathophysiological pathway tumorigenesis be involved lung cancer, glioma, hepatocellular carcinoma, leukemia, so on. This review combs effects on each phase fate determination, three features are discussed. takes part processes ranging from tumor death via pathways like mitochondrial stress, endoplasmic reticulum ferroptosis. It can affect by engaging complex relationships death, cancer. The influence progression is multi-stage interlaced process that includes two aspects promotion inhibition, with mitochondria core regulation. A deeper more comprehensive understanding conducive exploring therapies.
Language: Английский
Citations
23
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 30, 2025
Homoharringtonine is a natural alkaloid with significant pharmacological potential that has demonstrated promising efficacy in the treatment of hematological malignancies recent years. This article systematically reviews mechanisms Homoharringtonine, focusing on its key roles inducing apoptosis, inhibiting cell cycle progression, and reducing migration invasion. Additionally, HHT exhibits multiple biological activities, including immunomodulation, antiviral effects, anti-fibrotic properties, studies also revealing neuroprotective functions. In clinical trials, malignancies, particularly various types such as acute myeloid leukemia chronic leukemia. Despite antitumor effects observed applications, low bioavailability side remain major challenges limit widespread use. details latest research advancements aimed at enhancing drug delivery systems nanoparticles liposomes, well chemical modification strategies. These approaches not only improve HHT’s vivo but enhance targeting ability while toxicity to normal cells. Furthermore, combination other drugs presents broader prospects for treatment. By exploring diverse activities depth, this aims provide foundation developing novel therapeutic based products, thereby advancing application cancer fields.
Language: Английский
Citations
3
Cellular Oncology, Journal Year: 2023, Volume and Issue: 46(3), P. 503 - 519
Published: Jan. 25, 2023
Lung cancer is the most common and leading cause of cancer-related death worldwide. However, mechanisms its progression remained unclear new treatments against this disease are rapidly emerging. As a novel preclinical model, patient-derived organoid (PDO) can also be established from patient's tumor tissue cultured in laboratory, which preserves key biological characteristics original tumor. Compared to xenograft (PDX) model lung cancer, culture success rate improved, time cost establishment largely reduced. PDO expected provide more individual predict efficacy anti-cancer treatment vitro. This paper summarizes current application translational research cancer.
Language: Английский
Citations
26
Cancer Letters, Journal Year: 2024, Volume and Issue: 587, P. 216735 - 216735
Published: Feb. 16, 2024
Language: Английский
Citations
15
Cellular and Molecular Life Sciences, Journal Year: 2024, Volume and Issue: 81(1)
Published: Feb. 5, 2024
Abstract Metastatic cancer is a major cause of cancer-related mortality; however, the complex regulation process remains to be further elucidated. A large amount preliminary investigations focus on role epigenetic mechanisms in metastasis. Notably, posttranslational modifications were found critically involved malignancy, thus attracting considerable attention. Beyond acetylation, novel forms acylation have been recently identified following advances mass spectrometry, proteomics technologies, and bioinformatics, such as propionylation, butyrylation, malonylation, succinylation, crotonylation, 2-hydroxyisobutyrylation, lactylation, among others. These acylations play pivotal roles regulating different aspects energy mechanism mediating signal transduction by covalently modifying histone or nonhistone proteins. Furthermore, these their enzymes show promise regarding diagnosis treatment tumors, especially tumor Here, we comprehensively review identification characterization 11 acylations, corresponding enzymes, highlighting significance for We also potential application clinical therapeutic targets diagnostic predictors, discussing current obstacles future research prospects.
Language: Английский
Citations
10
Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)
Published: Sept. 27, 2022
Abstract Digestive system diseases arise primarily through the interplay of genetic and environmental influences; there is an urgent need in elucidating pathogenic mechanisms these deploy personalized treatments. Traditional long-established model systems rarely reproduce either tissue complexity or human physiology faithfully; shortcomings underscore for better models. Organoids represent a promising research model, helping us gain more profound understanding digestive organs; this can also be used to provide patients with precise individualized treatment build rapid vitro test models drug screening gene/cell therapy, linking basic clinical treatment. Over past few decades, use organoids has led advanced composition each organ facilitated disease modeling, chemotherapy dose prediction, CRISPR-Cas9 intervention, high-throughput screening, identification SARS-CoV-2 targets, infection. However, existing mainly include epithelial system. In order reveal mechanism diseases, it necessary establish completer physiological organoid model. Combining techniques treatments different formulations approach that requires further exploration. This review highlights advancements field technology from perspectives modeling therapy.
Language: Английский
Citations
33