From E-Waste to High-Value Materials: Sustainable Synthesis of Metal, Metal Oxide, and MOF Nanoparticles from Waste Printed Circuit Boards DOI Creative Commons
Tatiana Pineda-Vásquez, Leidy Rendón-Castrillón, Margarita Ramírez-Carmona

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 14(1), P. 69 - 69

Published: Dec. 26, 2023

The exponential growth of electronic waste (e-waste) has raised significant environmental concerns, with projections indicating a surge to 74.7 million metric tons e-waste generated by 2030. Waste printed circuit boards (WPCBs), constituting approximately 10% all e-waste, are particularly intriguing due their high content valuable metals and rare earth elements. However, the presence hazardous elements necessitates sustainable recycling strategies. This review explores innovative approaches metal nanoparticle synthesis from WPCBs. Efficient recovery WPCBs begins disassembly utilization advanced equipment for optimal separation. Various pretreatment techniques, including selective leaching magnetic separation, enhance efficiency. Green systems such as biohydrometallurgy offer eco-friendly alternatives, selectivity. Converting ions into nanoparticles involves concentration transformation methods like chemical precipitation, electrowinning, dialysis. These vital transforming recovered nanoparticles, promoting resource recycling. Sustainable green utilizing natural sources, microorganisms plants, discussed, focus on applications in producing well-defined nanoparticles. Nanoparticles derived find drug delivery, microelectronics, antimicrobial materials, remediation, diagnostics, catalysis, agriculture, etc. They contribute wastewater treatment, photocatalysis, protective coatings, biomedicine. important implications this lie its identification pivotal solution paving way practices supply materials diverse industrial applications.

Language: Английский

Nano-drug delivery system targeting tumor microenvironment: A prospective strategy for melanoma treatment DOI Open Access
Mengdan Xu, Shenglong Li

Cancer Letters, Journal Year: 2023, Volume and Issue: 574, P. 216397 - 216397

Published: Sept. 18, 2023

Language: Английский

Citations

64
Elesclomol Loaded Copper Oxide Nanoplatform Triggers Cuproptosis to Enhance Antitumor Immunotherapy DOI Creative Commons
Xufeng Lu, Xiaohong Chen,

Chengyin Lin

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 11(18)

Published: March 2, 2024

Abstract The induction of cuproptosis, a recently identified form copper‐dependent immunogenic cell death, is promising approach for antitumor therapy. However, sufficient accumulation intracellular copper ions (Cu 2+ ) in tumor cells essential inducing cuproptosis. Herein, an intelligent cuproptosis‐inducing nanosystem constructed by encapsulating oxide (CuO) nanoparticles with the ionophore elesclomol (ES). After uptake cells, ES@CuO degraded to release Cu and ES synergistically trigger thereby significantly inhibiting growth murine B16 melanoma cells. Moreover, further promoted cuproptosis‐mediated immune responses reprogrammed immunosuppressive microenvironment increasing number tumor‐infiltrating lymphocytes secreted inflammatory cytokines. Additionally, combining programmed death‐1 (PD‐1) immunotherapy substantially increased efficacy melanoma. Overall, findings this study can lead use novel strategy therapy, which may enhance checkpoint inhibitor

Language: Английский

Citations

61
Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression DOI Creative Commons

Yunna Chen,

Qianqian Zhou,

Zongfang Jia

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(9), P. 3834 - 3854

Published: June 3, 2024

Immunotherapy is an important cancer treatment method that offers hope for curing patients. While immunotherapy has achieved initial success, a major obstacle to its widespread adoption the inability benefit majority of The success or failure closely linked tumor's immune microenvironment. Recently, there been significant attention on strategies regulate tumor microenvironment in order stimulate anti-tumor responses immunotherapy. distinctive physical properties and design flexibility nanomedicines have extensively utilized target cells (including tumor-associated macrophages (TAMs), T cells, myeloid-derived suppressor (MDSCs), fibroblasts (TAFs)), offering promising advancements In this article, we reviewed aimed at targeting various focus models are based nanomedicines, with goal inducing enhancing improve It worth noting combining other treatments, such as chemotherapy, radiotherapy, photodynamic therapy, can maximize therapeutic effects. Finally, identified challenges nanotechnology-mediated needs overcome more effective nanosystems.

Language: Английский

Citations

14
FeP‐Based Nanotheranostic Platform for Enhanced Phototherapy/Ferroptosis/Chemodynamic Therapy DOI
Na An,

Shuanglong Tang,

Yuwei Wang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(32)

Published: March 27, 2024

Ferroptosis is an iron-dependent and lipid peroxides (LPO)-overloaded programmed damage cell death, induced by glutathione (GSH) depletion peroxide 4 (GPX4) inactivation. However, the inadequacy of endogenous iron reactive oxygen species (ROS) restricts efficacy ferroptosis. To overcome this obstacle, a near-infrared photo-responsive FeP@PEG NPs fabricated. Exogenous pool can enhance effect ferroptosis via GSH further regulate GPX4 Generation ·OH derived from Fenton reaction proved increased accumulation peroxides. The heat generated photothermal therapy ROS photodynamic apoptosis under (NIR-808 nm) irradiation, as evidenced mitochondrial dysfunction content. significantly inhibit growth several types cancer cells in vitro vivo, which validated theoretical experimental results. Meanwhile, show excellent T2-weighted magnetic resonance imaging (MRI) property. In summary, FeP-based nanotheranostic platform for enhanced phototherapy/ferroptosis/chemodynamic provides reliable opportunity clinical theranostics.

Language: Английский

Citations

7
Synthesis, characterization and assessment of anticancer potency of oxcarbazepine with folic acid conjugated Fe2O3 nanostructures as nano-drugs DOI

D.M. Surendra,

C.B. Praveen Kumar,

C. Nandini

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1306, P. 137842 - 137842

Published: Feb. 20, 2024

Language: Английский

Citations

6
Tissue Inhibitor of Metalloproteinase 3: Unravelling Its Biological Function and Significance in Oncology DOI Open Access
Wei‐Ting Lee, Pei‐Ying Wu,

Ya-Min Cheng

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(6), P. 3191 - 3191

Published: March 10, 2024

Tissue inhibitor of metalloproteinases-3 (TIMP3) is vital in regulating several biological processes. TIMP3 exerts antitumour effects via matrix metalloproteinase (MMP)-dependent and MMP-independent pathways. Due to promoter methylation miRNA binding, expression has been observed decrease various cancers. Consequently, the migration invasion cancer cells increases. Conflicting results have reported that levels primary advanced cancers are higher than those healthy tissues. Therefore, role biology progression needs be elucidated. This review provides an overview TIMP3, from its function on Moreover, gynaecological discussed detail. associated with cervical adenocarcinoma as well development serous ovarian breast metastasis. However, relationship between endometrial remains unclear. may a useful biomarker for potential target future therapy.

Language: Английский

Citations

6
Lymph node Metastasis in Cancer: Clearing the Clouds to See the Dawn DOI
Zi‐Zhan Li,

Kan Zhou,

Qiuji Wu

et al.

Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: 204, P. 104536 - 104536

Published: Oct. 18, 2024

Language: Английский

Citations

6
Biomimetic Cell-Derived Nanoparticles: Emerging Platforms for Cancer Immunotherapy DOI Creative Commons
Tingting Hu,

Yuezhou Huang,

Jing Liu

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1821 - 1821

Published: June 26, 2023

Cancer immunotherapy can significantly prevent tumor growth and metastasis by activating the autoimmune system without destroying normal cells. Although cancer has made some achievements in clinical treatment, it is still restricted systemic immunotoxicity, immune cell dysfunction, heterogeneity, immunosuppressive microenvironment (ITME). Biomimetic cell-derived nanoparticles are attracting considerable interest due to their better biocompatibility lower immunogenicity. Moreover, biomimetic achieve different preferred biological effects inherent abundant source cell-relevant functions. This review summarizes latest developments for immunotherapy, discusses applications of each analyzes challenges transformation.

Language: Английский

Citations

11
Global trends in bufalin application research for cancer from 2003 to 2022: A bibliometric and visualised analysis DOI Creative Commons

Donghao Tang,

Yuejiao Feng,

Jiahao Lu

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24395 - e24395

Published: Jan. 1, 2024

BackgroundBufalin, the main active ingredient of traditional Chinese medicine huachansu, is used in clinical treatment colorectal cancer and has multiple effects, including inhibition migratory invasion, reversal multi-drug resistance, induction apoptosis differentiation, angiogenesis.MethodsWe collected relevant articles on bufalin from 2003 to 2022 using Web Science platform, analysed information VOSviewer, CiteSpace, Microsoft Excel categorise summarise publications over past 20 years.ResultsWe 371 papers, with a steady increase number published globally. China highest articles, whereas Japan citations. Currently, there considerable enthusiasm for investigating anti-tumour mechanism optimising drug delivery systems its administration.ConclusionFor first time, we present comprehensive overview papers worldwide two decades progress application tumour therapy. We summarised key authors, institutions, countries that have contributed field potential cancer. This will help other researchers obtain an field, enhance collaboration knowledge sharing, promote future research bufalin.

Language: Английский

Citations

4
Targeted Nanoprobes Enabled Precision Theranostics in Triple‐Negative Breast Cancer DOI Open Access
Ke Ma, Meng Yin, Kezheng Chen

et al.

The Chemical Record, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Triple-negative breast cancer (TNBC) represents a highly aggressive and prognostically unfavorable subtype of cancer, characterized by the absence common hormone receptors, which renders conventional therapies largely ineffective. This review comprehensively examines molecular clinical characteristics TNBC, underscoring substantial challenges inherent in its treatment innovative potential targeted nanoprobes advancing both diagnostic therapeutic paradigms. Through modification targeting molecules, can deliver agents specific to TNBC cells, thus significantly improving sensitivity modalities efficacy interventions. Our discussion systematically explores application various molecules their advantages limitations. In addition, this presents series multifunctional that are designed perform functions, providing synergistic approach TNBC. These advanced enable precise tumor localization while monitoring response real time, facilitating more personalized dynamic regimen. The major obstacles encountered during translation discussed detail. use leap forward medicine for current research efforts will continue refine these technologies improve applicability.

Language: Английский

Citations

0