Green and sustainable synthesis of nanomaterials: Recent advancements and limitations

Environmental Research, Journal Year: 2023, Volume and Issue: 231, P. 116316 - 116316

Published: June 1, 2023

Language: Английский

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NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

Journal of Cellular Physiology, Journal Year: 2022, Volume and Issue: 237(7), P. 2770 - 2795

Published: May 13, 2022

Metastasis of tumor cells is a complex challenge and significantly diminishes the overall survival prognosis cancer patients. The epithelial-to-mesenchymal transition (EMT) well-known mechanism responsible for invasiveness cells. A number molecular pathways can regulate EMT in nuclear factor-kappaB (NF-κB) one them. translocation NF-κB p65 induce transcription several genes involved induction. present review describes interaction their association progression. Due to oncogenic role signaling, its activation enhances metastasis via This has been confirmed various cancers including brain, breast, lung gastric cancers, among others. ZEB1/2, transforming growth factor-β, Slug as inducers undergo upregulation by promote After induction driven NF-κB, significant decrease occurs E-cadherin levels, while N-cadherin vimentin levels an increase. noncoding RNAs potentially also function upstream mediators modulate NF-κB/EMT axis cancers. Moreover, mediating drug resistance Thus, suppressing sensitivity chemotherapeutic agents.

Language: Английский

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Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 351, P. 50 - 80

Published: Sept. 20, 2022

The site-specific delivery of antitumor agents is importance for providing effective cancer suppression. Poor bioavailability anticancer compounds and the presence biological barriers prevent their accumulation in tumor sites. These obstacles can be overcome using liposomal nanostructures. challenges chemotherapy stimuli-responsive nanocarriers are first described current review. Then, liposomes including pH-, redox-, enzyme-, light-, thermo- magneto-sensitive nanoparticles discussed potential drugs emphasized. pH- or redox-sensitive based on internal stimulus release drug response to a mildly acidic pH GSH, respectively. pH-sensitive mediate endosomal escape via proton sponge. multifunctional responsive both redox have more capacity at site compared alone. magnetic field NIR irradiation exploited external stimulation liposomes. light-responsive when they exposed irradiation; thermosensitive-liposomes temperature >40 °C there hyperthermia; magneto-responsive field. smart nanoliposomes also co-delivery genes synergistic therapy. Due lack long-term toxicity liposomes, utilized near future treatment patients.

Language: Английский

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Multifunctional nanoparticle-mediated combining therapy for human diseases

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Jan. 1, 2024

Abstract Combining existing drug therapy is essential in developing new therapeutic agents disease prevention and treatment. In preclinical investigations, combined effect of certain known drugs has been well established treating extensive human diseases. Attributed to synergistic effects by targeting various pathways advantages, such as reduced administration dose, decreased toxicity, alleviated resistance, combinatorial treatment now being pursued delivering combat major clinical illnesses, cancer, atherosclerosis, pulmonary hypertension, myocarditis, rheumatoid arthritis, inflammatory bowel disease, metabolic disorders neurodegenerative Combinatorial involves combining or co-delivering two more for a specific disease. Nanoparticle (NP)-mediated delivery systems, i.e., liposomal NPs, polymeric NPs nanocrystals, are great interest wide range due targeted delivery, extended release, higher stability avoid rapid clearance at infected areas. This review summarizes targets diseases, clinically approved combinations the development multifunctional emphasizes strategies based on severe Ultimately, we discuss challenging NP-codelivery translation provide potential approaches address limitations. offers comprehensive overview recent cutting-edge NP-mediated combination

Language: Английский

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Mesoporous Bioactive Glasses in Cancer Diagnosis and Therapy: Stimuli‐Responsive, Toxicity, Immunogenicity, and Clinical Translation

Advanced Science, Journal Year: 2021, Volume and Issue: 9(2)

Published: Nov. 19, 2021

Cancer is one of the top life-threatening dangers to human survival, accounting for over 10 million deaths per year. Bioactive glasses have developed dramatically since their discovery 50 years ago, with applications that include therapeutics as well diagnostics. A new system within bioactive glass family, mesoporous (MBGs), has evolved into a multifunctional platform, thanks MBGs easy-to-functionalize nature and tailorable textural properties-surface area, pore size, volume. Although yet meet potential in tumor treatment imaging practice, recently research shed light on distinguished capabilities promising theranostic systems cancer therapy. This review presents progress field MBG diagnosis therapy, including synthesis MBGs, mechanistic overview application drug monitoring, therapy ( particularly, targeted delivery stimuli-responsive nanoplatforms), immunological profile MBG-based nanodevices reference development novel therapeutics.

Language: Английский

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Polymer-Based Nanofiber–Nanoparticle Hybrids and Their Medical Applications

Polymers, Journal Year: 2022, Volume and Issue: 14(2), P. 351 - 351

Published: Jan. 17, 2022

The search for higher-quality nanomaterials medicinal applications continues. There are similarities between electrospun fibers and natural tissues. This property has enabled to make significant progress in medical applications. However, limited tissue scaffolding When nanoparticles nanofibers combined, the composite material can perform more functions, such as photothermal, magnetic response, biosensing, antibacterial, drug delivery biosensing. To prepare nanofiber nanoparticle hybrids (NNHs), there two primary ways. electrospinning technology was used produce NNHs a single step. An alternate way is use self-assembly technique create fibers. paper describes creation of from routinely biocompatible polymer composites. Single-step procedures methodologies discuss preparation NNHs. It combines recent research discoveries focus on application release, engineering last years.

Language: Английский

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(Nano)platforms in bladder cancer therapy: Challenges and opportunities

Bioengineering & Translational Medicine, Journal Year: 2022, Volume and Issue: 8(1)

Published: June 8, 2022

Urological cancers are among the most common malignancies around world. In particular, bladder cancer severely threatens human health due to its aggressive and heterogeneous nature. Various therapeutic modalities have been considered for treatment of although prognosis remains unfavorable. It is perceived that depends on an interdisciplinary approach combining biology engineering. The nanotechnological approaches introduced in various cancers, especially cancer. current review aims emphasize highlight possible applications nanomedicine eradication tumor. Nanoparticles can improve efficacy drugs therapy through elevating their bioavailability. potential genetic tools such as siRNA miRNA gene expression regulation be boosted using nanostructures by facilitating internalization accumulation at tumor sites cells. provide photodynamic photothermal ROS overgeneration hyperthermia, respectively, suppression Furthermore, remodeling microenvironment infiltration immune cells purpose immunotherapy achieved cargo-loaded nanocarriers. Nanocarriers mainly internalized endocytosis, proper design smart nanoparticles pH-, redox-, light-responsive nanocarriers importance targeted therapy. Bladder biomarkers detected timely diagnosis patients. Based site, they employed imaging. clinical translation challenges also covered review.

Language: Английский

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Biological impact and therapeutic perspective of targeting PI3K/Akt signaling in hepatocellular carcinoma: Promises and Challenges

Pharmacological Research, Journal Year: 2022, Volume and Issue: 187, P. 106553 - 106553

Published: Nov. 16, 2022

Cancer progression results from activation of various signaling networks. Among these, PI3K/Akt contributes to proliferation, invasion, and inhibition apoptosis. Hepatocellular carcinoma (HCC) is a primary liver cancer with high incidence rate, especially in regions prevalence viral hepatitis infection. Autoimmune disorders, diabetes mellitus, obesity, alcohol consumption, inflammation can also lead initiation development HCC. The treatment HCC depends on the identification oncogenic factors that tumor cells develop resistance therapy. present review article focuses role progression. Activation promotes glucose uptake, favors glycolysis increases cell proliferation. It inhibits both apoptosis autophagy while promoting survival. stimulates epithelial-to-mesenchymal transition (EMT) matrix-metalloproteinase (MMP) expression during metastasis. In addition increasing colony formation capacity facilitating spread cells, angiogenesis. Therefore, silencing prevents aggressive behavior. confer drug resistance, particularly sorafenib, decreases radio-sensitivity cells. Anti-cancer agents, like phytochemicals small molecules suppress by limiting Being upregulated tissues clinical samples, be used as biomarker predict patients' response

Language: Английский

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Tailoring Hyaluronic Acid Hydrogels for Biomedical Applications

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(49)

Published: Sept. 7, 2023

Abstract Hyaluronic acid (HA) is an attractive anionic polysaccharide polymer with inherent pharmacological properties and versatile chemical groups for modification. Due to their water retention ability, biocompatibility, biodegradation, cluster of differentiation‐44 targeting, highly designable capacity, HA hydrogels have been emerging biomaterial, showing tailoring performance in terms modifications hydrogel forms. Various preparation technologies developed the fabrication unique structures functions. They utilized diverse biomedical applications like drug delivery tissue engineering scaffolds. Herein, this review comprehensively summarizes derivatives different molecule weights functional modifications. Then various methods obtain forms nanogel, nanofiber, microparticle, microneedle patch, injectable hydrogel, scaffold are reviewed as well. The emphasis focused on shining these anti‐bacteria, anti‐inflammation, wound healing, cancer treatment, regenerative medicine, psoriasis diagnosis, etc. potentials prospects subsequently given inspire further investigation, aiming at accelerating product translation from research clinic.

Language: Английский

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Graphene oxide nanoarchitectures in cancer biology: Nano-modulators of autophagy and apoptosis

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 503 - 522

Published: Jan. 20, 2023

Language: Английский

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