Recent progressions in biomedical and pharmaceutical applications of chitosan nanoparticles: A comprehensive review

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 231, P. 123354 - 123354

Published: Jan. 18, 2023

Language: Английский

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Current advance of nanotechnology in diagnosis and treatment for malignant tumors

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

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Functionalized chitosan for cancer nano drug delivery

Biotechnology Advances, Journal Year: 2023, Volume and Issue: 67, P. 108200 - 108200

Published: June 16, 2023

Language: Английский

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A comprehensive review of chitosan applications in paper science and technologies

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 309, P. 120665 - 120665

Published: Feb. 4, 2023

Language: Английский

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Multi-functional chitosan-based nanoparticles for drug delivery: Recent advanced insight into cancer therapy

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 315, P. 120972 - 120972

Published: May 6, 2023

Language: Английский

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Polysaccharide-based nanocarriers for efficient transvascular drug delivery

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 354, P. 167 - 187

Published: Jan. 9, 2023

Language: Английский

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Engineered Bio‐Based Hydrogels for Cancer Immunotherapy

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 16, 2024

Immunotherapy represents a revolutionary paradigm in cancer management, showcasing its potential to impede tumor metastasis and recurrence. Nonetheless, challenges including limited therapeutic efficacy severe immune-related side effects are frequently encountered, especially solid tumors. Hydrogels, class of versatile materials featuring well-hydrated structures widely used biomedicine, offer promising platform for encapsulating releasing small molecule drugs, biomacromolecules, cells controlled manner. Immunomodulatory hydrogels present unique capability augmenting immune activation mitigating systemic toxicity through encapsulation multiple components localized administration. Notably, based on biopolymers have gained significant interest owing their biocompatibility, environmental friendliness, ease production. This review delves into the recent advances bio-based immunotherapy synergistic combinatorial approaches, highlighting diverse applications. It is anticipated that this will guide rational design field immunotherapy, fostering clinical translation ultimately benefiting patients.

Language: Английский

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Shrimp Waste Upcycling: Unveiling the Potential of Polysaccharides, Proteins, Carotenoids, and Fatty Acids with Emphasis on Extraction Techniques and Bioactive Properties

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(4), P. 153 - 153

Published: March 28, 2024

Shrimp processing generates substantial waste, which is rich in valuable components such as polysaccharides, proteins, carotenoids, and fatty acids. This review provides a comprehensive overview of the valorization shrimp mainly shells, focusing on extraction methods, bioactivities, potential applications these bioactive compounds. Various techniques, including chemical extraction, microbial fermentation, enzyme-assisted microwave-assisted ultrasound-assisted pressurized techniques are discussed, highlighting their efficacy isolating acids from waste. Additionally, bioactivities associated with compounds, antioxidant, antimicrobial, anti-inflammatory, antitumor properties, among others, elucidated, underscoring pharmaceutical, nutraceutical, cosmeceutical applications. Furthermore, explores current utilization avenues for emphasizing importance sustainable resource management circular economy principles maximizing value Overall, this paper aims to provide insights into multifaceted aspects waste valorization, offering information researchers, industries, policymakers interested waste-management strategies.

Language: Английский

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Application of Nano-Inspired Scaffolds-Based Biopolymer Hydrogel for Bone and Periodontal Tissue Regeneration

Polymers, Journal Year: 2022, Volume and Issue: 14(18), P. 3791 - 3791

Published: Sept. 10, 2022

This review’s objectives are to provide an overview of the various kinds biopolymer hydrogels that currently used for bone tissue and periodontal regeneration, list advantages disadvantages using them, assess how well they might be nanoscale fabrication biofunctionalization, describe their production processes functionalization with active biomolecules. They applied in conjunction other materials (such as microparticles (MPs) nanoparticles (NPs)) novel techniques replicate physiological generation more faithfully. Enhancing biocompatibility created from blends natural synthetic biopolymers can result creation best scaffold match extracellular matrix (ECM) regeneration. Additionally, adding increase hydrogel stability a number biological effects. In this review, research study polysaccharide will critical creating valuable effective future impact predicted repairing defects.

Language: Английский

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A Sodium Alginate‐Based Multifunctional Nanoplatform for Synergistic Chemo‐Immunotherapy of Hepatocellular Carcinoma

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(33)

Published: May 22, 2023

Efficient hepatocellular carcinoma (HCC) treatment remains a significant challenge due to the inherent limitations of traditional strategies. The exploration polysaccharides' natural immunity for HCC immunotherapy is rarely explored. For this purpose, facile construction multifunctional nanoplatform, biotinylated aldehyde alginate-doxorubicin nano micelle (BEACNDOXM) reported in study synergistic chemo-immunotherapy by using constant β-D-mannuronic acid (M) units and modulated α-L-guluronic (G) alginate (ALG) structure. M show specific binding ability with mannose receptors (MRs) via strong receptor-ligand interactions, G serve as highly reactive conjugation sites biotin (Bio) DOX. Therefore, formulation not only integrates ALG immunogenic cell death (ICD) triggering function DOX, but also shows dual targeting properties cells MRs Bio (BRs)-mediated endocytosis. Notably, BEACNDOXM mediates tumor inhibitory efficiency 12.10% 4.70% higher than free DOX single controls, respectively, at an equivalent dose 3 mg kg-1 Hepa1-6 tumor-bearing mice. This reports first example integrating ICD effect anticancer drugs enhanced HCC.

Language: Английский

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