Published: Jan. 1, 2024
Language: Английский
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 370, P. 543 - 555
Published: May 11, 2024
Language: Английский
Citations
30
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 497, P. 154855 - 154855
Published: Aug. 14, 2024
Language: Английский
Citations
25
Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: 487, P. 150632 - 150632
Published: March 24, 2024
Language: Английский
Citations
24
Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 28, 2024
Abstract The advancement of biomaterials with antimicrobial and wound healing properties continues to present challenges. Macrophages are recognized for their significant role in the repair infection-related wounds. However, interaction between macrophages remains complex requires further investigation. In this research, we propose a new sequential immunomodulation method enhance expedite by leveraging immune bacteria-related wounds, utilizing novel mixed hydrogel dressing. matrix is derived from porcine acellular dermal (PADM) loaded type bioactive glass nanoparticles (MBG) doped magnesium (Mg-MBG) Curcumin (Cur). This hybrid demonstrates controlled release Cur, effectively eradicating bacterial infection early stage infection, subsequent Mg ions (Mg 2+ ) synergistically inhibits activation inflammation-related pathways (such as MAPK pathway, NF-κB TNF-α etc.), suppressing inflammatory response caused infection. Therefore, innovative can safely during Our design strategy explores immunomodulatory biomaterials, offering fresh approach tackle current clinical challenges associated treatment.
Language: Английский
Citations
10
Journal of Tissue Engineering, Journal Year: 2024, Volume and Issue: 15
Published: Jan. 1, 2024
The rising prevalence of diabetes has underscored concerns surrounding diabetic wounds and their potential to induce disability. intricate healing mechanisms are multifaceted, influenced by ambient microenvironment, including prolonged hyperglycemia, severe infection, inflammation, elevated levels reactive oxygen species (ROS), ischemia, impaired vascularization, altered wound physicochemical properties. In recent years, hydrogels have emerged as promising candidates for treatment owing exceptional biocompatibility resemblance the extracellular matrix (ECM) through a three-dimensional (3D) porous network. This review will first summarize microenvironment alterations occurring in wounds, aiming provide comprehensive understanding its pathogenesis, then classification recently developed be presented, encompassing properties such hypoglycemic effects, anti-inflammatory capabilities, antibacterial attributes, ROS scavenging abilities, promotion angiogenesis, pH responsiveness, more. primary objective is offer valuable reference repairing based on unique microenvironment. Moreover, this paper outlines avenues future advancements hydrogel dressings facilitate expedite process wounds.
Language: Английский
Citations
10
Gels, Journal Year: 2024, Volume and Issue: 10(7), P. 442 - 442
Published: July 4, 2024
Polymeric hydrogels are soft materials with a three-dimensional (3D) hydrophilic network capable of retaining and absorbing large amounts water or biological fluids. Due to their customizable properties, these extensively studied for developing matrices 3D cell culture scaffolds, drug delivery systems, tissue engineering. However, conventional still exhibit many drawbacks; thus, significant efforts have been directed towards dynamic that draw inspiration from organisms’ natural self-repair abilities after injury. The self-healing properties closely associated ability form, break, heal bonds in response various stimuli. primary objective this review is provide comprehensive overview by examining the types chemical them biopolymers utilized, elucidate nature enable modulation hydrogels’ properties. While ensure behavior hydrogels, they do not inherently confer adhesive Therefore, we also highlight emerging approaches acquire
Language: Английский
Citations
7
Materials & Design, Journal Year: 2024, Volume and Issue: 239, P. 112810 - 112810
Published: March 1, 2024
Bacterial infection is one of the main causes delayed wound healing. Hence, development antimicrobial dressings with good biocompatibility has high clinical significance and social value. The natural macromolecule, serum albumin, superior biocompatibility, low immunogenicity, a drug-carrying capacity. In this study, human albumin (HSA) was modified methacrylic anhydride to obtain photo-crosslinking properties. Then, HSA applied produce homogenized microspheres (HMS) through nitrogen elution-assisted microfluidic technique ultraviolet light. Effective loading vascular endothelial growth factor (VEGF) achieved by utilizing adsorption onto zinc ions their crosslinking His-tagged VEGF. prepared HMS-Zn@VEGF exhibited broad-spectrum antibacterial activity simultaneously exerted proangiogenic effects in vitro, effectively promoting healing infected wounds rats. vivo experiments using rats showed that promoted deposition collagen around wound, improved local inflammatory response, angiogenesis. conclusion, our have properties, angiogenic ability, which can be used for
Language: Английский
Citations
5
BME Frontiers, Journal Year: 2024, Volume and Issue: 5
Published: Jan. 1, 2024
Skin wound exposed to complex external environment for a long time is highly susceptible bacterial infection.
Language: Английский
Citations
5
Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 349, P. 122961 - 122961
Published: Nov. 13, 2024
Language: Английский
Citations
5
European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 201, P. 114371 - 114371
Published: June 15, 2024
Language: Английский
Citations
4