Journal of the American Society for Mass Spectrometry,
Journal Year:
2024,
Volume and Issue:
35(3), P. 622 - 630
Published: Feb. 8, 2024
Cyclodextrins
(CDs)
exhibit
versatile
self-assembly
properties
due
to
their
hydrophilic
and
hydrophobic
components,
with
applications
such
as
drug
delivery
selective
binding.
While
research
on
CD
is
extensive,
limited
studies
have
explored
aggregation
behavior,
particularly
in
interactions
small
ionic
guests.
The
present
work
investigates
the
structure
of
β-CD
tetramers
aggregated
alkali
metal
chloride
clusters
using
ion
mobility
spectrometry–mass
spectrometry
(IMS-MS).
results
revealed
that
diverse
structures
emerge
tetramer
depending
cluster
size.
Notably,
doubly
charged
exhibits
distinct
trends
specific
numbers
MCl
for
Na+
K+
ions.
After
initially
adopting
a
bucket-wheel
two
internal
cations,
transforms
into
new
isomer
tetrahedral
configuration
upon
addition.
formation
closely
linked
filling
cavity
volume
interactions,
which
possibly
compensate
weakened
hydrogen
bonds
between
CDs.
Theoretical
calculations
further
support
structures,
showing
well-matched
collision
cross-section
(CCS)
values
compared
experimental
CCS
values.
This
study
highlights
role
potential
templates,
leading
novel
assemblies.
Pharmaceutics,
Journal Year:
2025,
Volume and Issue:
17(3), P. 288 - 288
Published: Feb. 22, 2025
Cyclodextrins
(CDs)
have
revolutionized
the
pharmaceutical
industry
with
their
ability
to
enhance
stability,
solubility,
and
bioavailability
of
a
wide
range
active
substances.
These
cyclic
oligosaccharides,
unique
hydrophilic
exterior
hydrophobic
cavity,
form
inclusion
complexes
poorly
soluble
drugs,
improving
pharmacokinetic
profiles
therapeutic
efficacy.
This
review
explores
multifaceted
roles
cyclodextrins
in
formulations,
ranging
from
oral,
ophthalmic,
parenteral,
topical
applications
emerging
use
targeted
therapies,
gene
delivery,
treatment
neurodegenerative,
cardiovascular,
infectious
diseases.
not
only
improve
drug
solubility
controlled
release
but
also
reduce
toxicity
side
effects,
leading
safer
more
effective
treatments.
Recent
advancements,
such
as
cyclodextrin-based
nanoparticles,
offer
promising
pathways
for
cancer
therapy,
chronic
disease
management,
personalized
medicine.
As
research
continues,
remain
at
forefront
innovation
delivery
systems,
ensuring
better
patient
outcomes
expanding
possibilities
modern
therapeutics.
International Journal of Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
654, P. 123976 - 123976
Published: March 6, 2024
As
cancer
being
the
most
difficult
disease
to
treat,
different
kinds
of
medications
and
therapeutic
approaches
have
been
prominently
developed
by
scientists.
For
certain
families
drugs,
such
as
immuno-therapeutics
or
antibody-drug
conjugates,
efficient
delivery
systems
are
required
during
administration
protect
drugs
from
chemical
degradation
biological
inactivation.
Delivery
with
ability
carry
therapeutics
diagnostic
agents
both,
hold
promising
potential
tackle
abnormalities
behind
cancer.
In
this
context,
review
provides
updated
insights
on
how
cyclodextrin-based
polymeric
nanosystems
become
an
effective
treatment
approach
against
Cyclodextrins
(CDs)
natural
oligosaccharides
that
famously
exploited
in
pharmaceutical
research
due
their
exceptional
quality
entrapping
water-insoluble
molecules
inside
hydrophobic
core
providing
enhanced
solubility
help
hydrophilic
exterior.
Combining
properties
CDs
nanoparticles
(PNPs)
brings
out
excellent
versatile
tunable
profiles,
thanks
submicron-sized
PNPs.
By
introducing
significance
CD
a
system,
collective
discussion
binding
release
mechanisms
CD-drug
complexation,
followed
characterization
studies
has
done
review.
Further,
light
recent
studies,
article
majorly
focuses
conveying
promoting
nanoscale
elevates
multifunctional
advantages
can
be
successfully
applied
combination
therapy
theranostics.
Moreover,
CD-based
including
CALAA-01,
CRLX101,
CRLX301,
demonstrated
improved
tumor
targeting,
reduced
side
effects,
prolonged
drug
preclinical
clinical
trials.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(22), P. 5319 - 5319
Published: Nov. 12, 2024
Cyclodextrins
(CDs)
have
garnered
significant
attention
in
various
scientific
and
industrial
fields
due
to
their
unique
ability
form
inclusion
complexes
with
a
wide
range
of
guest
molecules.
This
review
comprehensively
explores
the
latest
advancements
cyclodextrin
chemistry,
focusing
on
synthesis
characterization
derivatives
complexes.
examines
biological
activities
cyclodextrins,
highlighting
pharmacological
properties
pharmacokinetics,
discussing
promising
applications
drug
delivery
systems.
Furthermore,
utilization
including
role
nanomaterials
nanostructured
coatings,
as
well
potential
environmental
remediation,
are
explored.
The
present
research
also
addresses
critical
aspect
toxicity,
particularly
concerning
complexes,
providing
an
overview
current
understanding
safety
considerations.
Through
multidisciplinary
approach,
aim
is
complete
view
underscoring
versatility
impact
across
domains.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(10), P. 8780 - 8780
Published: May 15, 2023
This
review
focuses
on
the
methods
of
preparation
and
biological,
physiochemical,
theoretical
analysis
inclusion
complexes
formed
between
estrogens
cyclodextrins
(CDs).
Because
have
a
low
polarity,
they
can
interact
with
some
cyclodextrins’
hydrophobic
cavities
to
create
complexes,
if
their
geometric
properties
are
compatible.
For
last
forty
years,
estrogen-CD
been
widely
applied
in
several
fields
for
various
objectives.
example,
CDs
used
as
estrogen
solubilizers
absorption
boosters
pharmaceutical
formulations,
well
chromatographic
electrophoretic
procedures
separation
quantification.
Other
applications
include
removal
endocrine
disruptors
from
environmental
materials,
samples
mass
spectrometric
analysis,
or
solid-phase
extractions
based
complex
formation
CDs.
The
aim
this
is
gather
most
important
outcomes
works
related
topic,
presenting
results
synthesis,
silico,
vitro,
vivo
analysis.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1824 - 1824
Published: June 26, 2023
CRLX101
is
a
cyclodextrin-based
nanopharmaceutical
designed
to
improve
the
delivery
and
efficacy
of
anti-cancer
drug
camptothecin.
Cyclodextrins
have
unique
properties
that
can
enhance
solubility,
stability,
bioavailability,
making
them
an
attractive
option
for
delivery.
The
use
nanoparticles
potentially
reduce
toxicity
increase
therapeutic
index
compared
conventional
chemotherapy.
has
shown
promise
in
preclinical
studies,
demonstrating
enhanced
tumor
targeting
prolonged
release.
This
systematic
review
followed
PRISMA
guidelines,
assessing
cancer
treatment
using
clinical
trials.
Studies
from
January
2010
April
2023
were
searched
PubMed,
Scopus,
Web
Science,
Cochrane
Database
Systematic
Reviews,
specific
search
terms.
risk
bias
was
assessed
ROBINS-I
risk-of-bias
tools.
After
screening
6018
articles,
9
included
final
review.
These
conducted
between
2013
2022,
focused
on
patients
with
advanced
or
metastatic
resistant
standard
therapies.
often
combined
other
agents,
resulting
improvements
such
as
increased
progression-free
survival
benefit
rates.
Toxicity
generally
manageable,
common
adverse
events
including
fatigue,
nausea,
anemia.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(7), P. 4077 - 4077
Published: April 6, 2024
Stimuli-responsive
supramolecular
polymers
are
ordered
nanosized
materials
that
held
together
by
non-covalent
interactions
(hydrogen-bonding,
metal-ligand
coordination,
π-stacking
and,
host–guest
interactions)
and
can
reversibly
undergo
self-assembly.
Their
nature
endows
with
the
ability
to
respond
external
stimuli
(temperature,
light,
ultrasound,
electric/magnetic
field)
or
environmental
changes
pH,
redox
potential,
enzyme
activity),
making
them
attractive
candidates
for
a
variety
of
biomedical
applications.
To
date,
research
has
largely
evolved
in
development
smart
water-soluble
self-assemblies
aim
mimicking
biological
function
natural
systems.
Indeed,
there
is
wide
synthetic
biomaterials
formulated
responsiveness
control
trigger,
not
aqueous
The
design
responsive
ranges
from
use
hydrophobic
cores
(i.e.,
benzene-1,3,5-tricarboxamide)
introduction
macrocyclic
hosts
cyclodextrins).
In
this
review,
we
summarize
most
relevant
advances
achieved
stimuli-responsive
systems
used
transport
release
both
diagnosis
agents
therapeutic
drugs
order
prevent,
diagnose,
treat
human
diseases.
Analytica Chimica Acta,
Journal Year:
2024,
Volume and Issue:
1318, P. 342948 - 342948
Published: July 6, 2024
Cyclodextrins
are
a
well-established
system
which
form
inclusion
complexes
with
many
guest
molecules.
This
property
can
be
easily
exploited
to
develop
drug
delivery
systems.
Additionally,
carbon
dots
(CD)
low-toxic
photoluminescent
product
have
been
used
as
luminescent
tags.
The
combination
of
cyclodextrins
and
allows
obtaining
new
nanoplatform,
biocompatible
material,
both
capabilities,
increasing
well
the
internalization
by
cells
CD,
induced
cyclodextrins.
