Impact of New Ventilation and Hemodynamic Support Strategies on the Recovery of Critically Ill Patients with Acute Respiratory Distress Syndrome due to Sepsis: A Systematic Review DOI Creative Commons

Luisa Paulina Chafla Romero,

Ana Beatriz Batista e Silva,

Mónica Alexandra Caiza Asitimbay

et al.

Salud Ciencia y Tecnología, Journal Year: 2025, Volume and Issue: 5, P. 1320 - 1320

Published: Jan. 1, 2025

Acute Respiratory Distress Syndrome (ARDS) is a complication caused by sepsis and present burden in critical care with high mortality limited effective treatments. Advances ventilation hemodynamic support offer potential to improve recovery. Our aim systematically evaluate impact of new strategies on the recovery critically ill patients ARDS due sepsis. The research conducted Web Science, PubMed, Embase, Cochrane Library from January 2000 December 2023. We selected randomized controlled trials observational studies that looked at adult as main cause were focus inclusion criteria. Advanced fluid management, extracorporeal membrane oxygenation (ECMO) lung-protective among interventions. Survival rates, length mechanical breathing improvements rates outcomes examined. Low tidal volume reduced 31% 40% ventilator-induced lung injury. Research stated prone positioning improved moderate-to-severe ARDS. documented ECMO offered survival benefits refractory cases while conservative ventilator days without impacting mortality. monitoring titration perfusion Certain interventions such high-frequency oscillatory ventilation, showed benefit or increased risk. Emerging enhance sepsis-induced through individualized care. Future should refine these optimize minimizing risks.

Language: Английский

COVID-19 Complications: Oxidative Stress, Inflammation, and Mitochondrial and Endothelial Dysfunction DOI Open Access
Ekaterina Georgieva, Julian Ananiev,

Y. Yovchev

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(19), P. 14876 - 14876

Published: Oct. 4, 2023

SARS-CoV-2 infection, discovered and isolated in Wuhan City, Hubei Province, China, causes acute atypical respiratory symptoms has led to profound changes our lives. COVID-19 is characterized by a wide range of complications, which include pulmonary embolism, thromboembolism arterial clot formation, arrhythmias, cardiomyopathy, multiorgan failure, more. The disease caused worldwide pandemic, despite various measures such as social distancing, preventive strategies, therapeutic approaches, the creation vaccines, novel coronavirus infection (COVID-19) still hides many mysteries for scientific community. Oxidative stress been suggested play an essential role pathogenesis COVID-19, determining free radical levels patients with may provide insight into severity. generation abnormal oxidants under COVID-19-induced cytokine storm irreversible oxidation macromolecules subsequent damage cells, tissues, organs. Clinical studies have shown that oxidative initiates endothelial damage, increases risk complications post-COVID-19 or long-COVID-19 cases. This review describes radicals mediation mitochondrial dysfunction.

Language: Английский

Citations

64
Targeting immunometabolism against acute lung injury DOI Open Access

Li Ning,

Zou Shishi,

Bo Wang

et al.

Clinical Immunology, Journal Year: 2023, Volume and Issue: 249, P. 109289 - 109289

Published: March 12, 2023

Language: Английский

Citations

42
The impact of formaldehyde exposure on lung inflammatory disorders: Insights into asthma, bronchitis, and pulmonary fibrosis DOI Creative Commons
Asif Ahmad Bhat, Muhammad Afzal, Ahsas Goyal

et al.

Chemico-Biological Interactions, Journal Year: 2024, Volume and Issue: 394, P. 111002 - 111002

Published: April 9, 2024

Lung inflammatory disorders are a major global health burden, impacting millions of people and raising rates morbidity death across many demographic groups. An industrial chemical common environmental contaminant, formaldehyde (FA) presents serious concerns to the respiratory system, including onset aggravation lung disorders. Epidemiological studies have shown significant associations between FA exposure levels incidence severity several diseases. causes inflammation in tract via immunological activation, oxidative stress, airway remodelling, aggravating pre-existing pulmonary compromising function. Additionally, functions as sensitizer, causing allergic responses hypersensitivity pneumonitis sensitive people. Understanding complicated processes behind formaldehyde-induced is critical for directing targeted strategies aimed at minimizing exposures alleviating burden formaldehyde-related illnesses on health. This abstract explores intricate relationship diseases, asthma, bronchitis, inflammation, injury fibrosis.

Language: Английский

Citations

23
Advances in the Regulation of Macrophage Polarization by Mesenchymal Stem Cells and Implications for ALI/ARDS Treatment DOI Creative Commons
Chang Liu, Kun Xiao, Lixin Xie

et al.

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: July 8, 2022

Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is a common condition with high mortality. ALI/ARDS caused by multiple etiologies, and the main clinical manifestations are progressive dyspnea intractable hypoxemia. Currently, supportive therapy treatment, there remains lack of targeted effective therapeutic strategies. Macrophages important components innate immunity. M1 macrophages pro-inflammatory, while M2 anti-inflammatory promote tissue repair. Mesenchymal stem cells (MSCs) broad application prospects in regeneration due to their multi-directional differentiation potential along paracrine properties. MSCs can regulate balance M1/M2 macrophage polarization improve prognosis ALI/ARDS. In this paper, we review mechanisms which signaling pathways associated polarization. This expected provide new targets for treatment

Language: Английский

Citations

57
COVID-19 and Acute Kidney Injury DOI
James Hilton, Naomi Boyer, Mitra K. Nadim

et al.

Critical Care Clinics, Journal Year: 2022, Volume and Issue: 38(3), P. 473 - 489

Published: Jan. 10, 2022

Language: Английский

Citations

49
Pulmonary drug delivery for acute respiratory distress syndrome DOI Creative Commons
Qinqin Fei, Ian D. Bentley, Samir N. Ghadiali

et al.

Pulmonary Pharmacology & Therapeutics, Journal Year: 2023, Volume and Issue: 79, P. 102196 - 102196

Published: Jan. 20, 2023

Language: Английский

Citations

27
Acute Respiratory Distress Syndrome; A Review of Recent Updates and a Glance into the Future DOI Creative Commons
Husayn F. Ramji,

Maida Hafiz,

Hiba Hammad Altaq

et al.

Diagnostics, Journal Year: 2023, Volume and Issue: 13(9), P. 1528 - 1528

Published: April 24, 2023

Acute respiratory distress syndrome (ARDS) is a rapidly progressive form of failure that accounts for 10% admissions to the ICU and associated with approximately 40% mortality in severe cases. Despite significant healthcare burden, mainstay management remains supportive care. The recent pandemic SARS-CoV-2 has re-ignited worldwide interest exploring pathophysiology ARDS, looking innovative ideas treat this disease. Recently, many trials have been published utilizing different pharmacotherapy targets; however, long-term benefits these agents remain unknown. Metabolomics profiling stem cell transplantation offer strong enthusiasm may completely change outlook ARDS near future.

Language: Английский

Citations

26
Epigenetic perspectives associated with COVID-19 infection and related cytokine storm: an updated review DOI Creative Commons

Amit Dey,

K. Vaishak,

Dikshita Deka

et al.

Infection, Journal Year: 2023, Volume and Issue: 51(6), P. 1603 - 1618

Published: March 12, 2023

Abstract Purpose The COVID-19 pandemic caused by the novel Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2) has put world in a medical crisis for past three years; nearly 6.3 million lives have been diminished due to virus outbreak. This review aims update recent findings on infections from an epigenetic scenario and develop future perspectives of epi-drugs treat disease. Methods Original research articles studies related were searched analyzed Google Scholar/PubMed/Medline databases mainly between 2019 2022 brief work. Results Numerous in-depth mechanisms used SARS-CoV-2 going minimize consequences viral outburst. Angiotensin-Converting Enzyme receptors Transmembrane serine protease facilitate entry host cells. Upon internalization, it uses machinery replicate copies alter downstream regulation normal cells, causing infection-related morbidities mortalities. In addition, several regulations such as DNA methylation, acetylation, histone modifications, microRNA, other factors (age, sex, etc.) are responsible entry, its immune evasion, cytokine responses also play major modulatory role severity, which discussed detail this review. Conclusion Findings pathogenicity open new window possible therapeutical approach against COVID-19.

Language: Английский

Citations

24
S100A9 exacerbates sepsis-induced acute lung injury via the IL17-NFκB-caspase-3 signaling pathway DOI Creative Commons

Hui Pei,

Jianming Chen, Jie Qu

et al.

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 710, P. 149832 - 149832

Published: March 26, 2024

Sepsis-induced acute lung injury (ALI) is associated with considerable morbidity and mortality in critically ill patients. S100A9, a key endothelial factor, markedly upregulated sepsis-induced ALI; however, its specific mechanism of action has not been fully elucidated.

Language: Английский

Citations

10
A narrative review on the future of ARDS: evolving definitions, pathophysiology, and tailored management DOI Creative Commons
Lou’i Al-Husinat, Saif Azzam, Sarah Al Sharie

et al.

Critical Care, Journal Year: 2025, Volume and Issue: 29(1)

Published: Feb. 24, 2025

Acute respiratory distress syndrome (ARDS) is a severe complication of critical illness, characterized by bilateral lung infiltrates and hypoxemia. Its clinical pathophysiological heterogeneity poses challenges for both diagnosis treatment. This review outlines the evolution ARDS definitions, discusses underlying pathophysiology ARDS, examines implications its heterogeneity. Traditional definitions required invasive mechanical ventilation relied on arterial blood gas measurements to calculate PaO2/FiO2 ratio. Recent updates have expanded these criteria include patients receiving noninvasive support, such as high-flow nasal oxygen, adoption SpO2/FiO2 ratio an alternative While changes broaden diagnostic criteria, they also introduce additional complexity. heterogeneity—driven varying etiologies, subphenotypes, biological mechanisms—highlights limitations uniform management approach. Emerging evidence highlights presence distinct each defined unique molecular characteristics, offering pathway more precise therapeutic targeting. Advances in omics technologies—encompassing genomics, proteomics, metabolomics—are paving way precision-medicine approaches with potential revolutionize tailoring interventions individual patient profiles. paradigm shift from broad categories precise, subphenotype-driven care holds promise redefining landscape treatment and, ultimately, improving outcomes this complex, multifaceted syndrome.

Language: Английский

Citations

1