Modulation of Intratumoral Fusobacterium nucleatum to Enhance Sonodynamic Therapy for Colorectal Cancer with Reduced Phototoxic Skin Injury DOI Creative Commons
Xiao Qu, F Yin,

Manman Pei

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(12), P. 11466 - 11480

Published: May 18, 2023

Intratumoral pathogens can contribute to cancer progression and affect therapeutic response. Fusobacterium nucleatum, a core pathogen of colorectal (CRC), is an important cause low efficacy metastasis. Thus, the modulation intratumoral may provide target for therapy metastasis inhibition. Herein, we propose F. nucleatum-modulating strategy enhancing CRC inhibiting lung by designing antibacterial nanoplatform (Au@BSA-CuPpIX), which produced reactive oxygen species (ROS) under ultrasound exhibited strong activity. Importantly, Au@BSA-CuPpIX reduced levels apoptosis-inhibiting proteins thereby ROS-induced apoptosis. In vivo results demonstrated that effectively eliminated nucleatum enhance sonodynamic (SDT) orthotopic inhibit Notably, entrapped gold nanoparticles phototoxicity metalloporphyrin accumulated in skin during tumor treatment, preventing severe inflammation damage skin. Therefore, this study proposes elimination effect SDT, thus providing promising paradigm improving treatment with fewer toxic side effects promoting clinical translational potential SDT.

Language: Английский

Gut microbiota in colorectal cancer development and therapy DOI
Chi Chun Wong, Jun Yu

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(7), P. 429 - 452

Published: May 11, 2023

Language: Английский

Citations

286
Role of the Gut Microbiota and Its Metabolites in Tumorigenesis or Development of Colorectal Cancer DOI Creative Commons
Ruize Qu, Yi Zhang,

Yanpeng Ma

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(23)

Published: June 1, 2023

Colorectal cancer (CRC) is the most common of digestive system with high mortality and morbidity rates. Gut microbiota found in intestines, especially colorectum, has structured crosstalk interactions host that affect several physiological processes. The gut include CRC-promoting bacterial species, such as Fusobacterium nucleatum, Escherichia coli, Bacteroides fragilis, CRC-protecting Clostridium butyricum, Streptococcus thermophilus, Lacticaseibacillus paracasei, which along other microorganisms, viruses fungi, play critical roles development CRC. Different features are identified patients early-onset CRC, combined different patterns between fecal intratumoral microbiota. may be beneficial diagnosis treatment CRC; some bacteria serve biomarkers while others regulators chemotherapy immunotherapy. Furthermore, metabolites produced by essential CRC cells. Harmful primary bile acids short-chain fatty acids, whereas others, including ursodeoxycholic acid butyrate, impede tumor progression. This review focuses on its metabolites, their potential development, diagnosis,

Language: Английский

Citations

104
A Review of Gut Microbiota‐Derived Metabolites in Tumor Progression and Cancer Therapy DOI Creative Commons
Qiqing Yang, Bin Wang, Qinghui Zheng

et al.

Advanced Science, Journal Year: 2023, Volume and Issue: 10(15)

Published: March 23, 2023

Abstract Gut microbiota‐derived metabolites are key hubs connecting the gut microbiome and cancer progression, primarily by remodeling tumor microenvironment regulating signaling pathways in cells multiple immune cells. The use of microbial radiotherapy chemotherapy mitigates severe side effects from treatment improves efficacy treatment. Immunotherapy combined with effectively activates system to kill tumors overcomes drug resistance. Consequently, various novel strategies have been developed modulate metabolites. Manipulation genes involved metabolism using synthetic biology approaches directly affects levels metabolites, while fecal transplantation phage affect altering composition microbiome. However, some harbor paradoxical functions depending on context (e.g., type cancer). Furthermore, metabolic microorganisms certain anticancer drugs such as irinotecan gemcitabine, render ineffective or exacerbate their adverse effects. Therefore, a personalized comprehensive consideration patient's condition is required when employing treat cancer. purpose this review summarize correlation between cancer, provide fresh ideas for future scientific research.

Language: Английский

Citations

99
Metabolism and Colorectal Cancer DOI Creative Commons
Joseph C. Sedlak, Ömer Yılmaz, Jatin Roper

et al.

Annual Review of Pathology Mechanisms of Disease, Journal Year: 2022, Volume and Issue: 18(1), P. 467 - 492

Published: Nov. 2, 2022

Reprogrammed metabolism is a hallmark of colorectal cancer (CRC). CRC cells are geared toward rapid proliferation, requiring nutrients and the removal cellular waste in nutrient-poor environments. Intestinal stem (ISCs), primary cell origin for CRCs, must adapt their along adenoma-carcinoma sequence to unique features complex microenvironment that include interactions with intestinal epithelial cells, immune stromal commensal microbes, dietary components. Emerging evidence implicates modifiable risk factors related environment, such as diet, important pathogenesis. Here, we focus on describing ISCs, diets influence initiation, genetics metabolism, tumor microenvironment. The mechanistic links between environmental factors, metabolic adaptations, enhancing or supporting tumorigenesis becoming better understood. Thus, greater knowledge holds promise improved prevention treatment.

Language: Английский

Citations

97
Microbiota-derived tryptophan catabolites mediate the chemopreventive effects of statins on colorectal cancer DOI Creative Commons
Ji‐Xuan Han, Zhi‐Hang Tao, Jilin Wang

et al.

Nature Microbiology, Journal Year: 2023, Volume and Issue: 8(5), P. 919 - 933

Published: April 17, 2023

Epidemiological studies have indicated an association between statin use and reduced incidence of colorectal cancer (CRC), work in preclinical models has demonstrated a potential chemopreventive effect. Statins are also associated with dysbiosis the gut microbiome, yet role microbiome protective effect statins CRC is unclear. Here we validated by retrospectively analysing cohort patients who underwent colonoscopies. This was confirmed patient cohorts, found that tumour burden partly due to modulation microbiota. Specifically, commensal Lactobacillus reuteri increased as result microbial tryptophan availability after atorvastatin treatment. Our vivo further revealed L. administration suppressed tumorigenesis via catabolite, indole-3-lactic acid (ILA). ILA exerted anti-tumorigenic effects downregulating IL-17 signalling pathway. metabolite inhibited T helper 17 cell differentiation targeting nuclear receptor, RAR-related orphan receptor γt (RORγt). Together, our study provides insights into anti-cancer mechanism driven suggests interventions or could complement chemoprevention strategies for CRC.

Language: Английский

Citations

93
The Current and Future Perspectives of Postbiotics DOI Creative Commons

Bing Liang,

Dongming Xing

Probiotics and Antimicrobial Proteins, Journal Year: 2023, Volume and Issue: 15(6), P. 1626 - 1643

Published: Feb. 10, 2023

With the emphasis on intestinal health, probiotics have exploded into a vast market potential. However, new scientific evidence points out that beneficial health benefits of are not necessarily directly related to viable bacteria. metabolites or bacterial components live bacteria driving force behind promotion. Therefore, scientists gradually noticed effects based itself, metabolites, cell lysates, and these factors officially named "postbiotics" by ISAPP. Postbiotic diverse outperform in terms technology, safety, cost due their good absorption, metabolism, organismal distribution. Postbiotics been shown bioactivities such as antimicrobial, antioxidant, anti-inflammatory, anti-proliferative, immunomodulation. Moreover, numerous studies revealed significant potential postbiotics for disease treatment. This paper first presents production classification with examples from lactic acid (LAB), followed mechanisms action most recent pre-clinical clinical wide range non-clinical applications postbiotics. Furthermore, current future prospects postbiotic commercial available products discussed. Finally, we comment knowledge gaps several examples.

Language: Английский

Citations

91
Microenvironmental ammonia enhances T cell exhaustion in colorectal cancer DOI Creative Commons
Hannah N. Bell, Amanda K. Huber, Rashi Singhal

et al.

Cell Metabolism, Journal Year: 2022, Volume and Issue: 35(1), P. 134 - 149.e6

Published: Dec. 16, 2022

Language: Английский

Citations

81
The Influence of Gut Microbiota on Oxidative Stress and the Immune System DOI Creative Commons

C Kunst,

Stephan Schmid,

M Michalski

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(5), P. 1388 - 1388

Published: May 8, 2023

The human gastrointestinal tract is home to a complex microbial community that plays an important role in the general well-being of entire organism. gut microbiota generates variety metabolites and thereby regulates many biological processes, such as regulation immune system. In gut, bacteria are direct contact with host. major challenge here prevent unwanted inflammatory reactions on one hand other ensure system can be activated when pathogens invade. Here REDOX equilibrium utmost importance. This controlled by either directly or indirectly via bacterial-derived metabolites. A balanced microbiome sorts for stable balance, whereas dysbiosis destabilizes this equilibrium. An imbalanced status affects disrupting intracellular signaling promoting responses. we (i) focus most common reactive oxygen species (ROS) (ii) define transition from state oxidative stress. Further, (iii) describe ROS regulating Thereafter, (iv) examine influence homeostasis how shifts pro- anti-oxidative cellular conditions suppress promote responses inflammation.

Language: Английский

Citations

76
Gut Microbiota in Colorectal Cancer: Biological Role and Therapeutic Opportunities DOI Open Access
Himani Pandey, Daryl W. T. Tang, Sunny H. Wong

et al.

Cancers, Journal Year: 2023, Volume and Issue: 15(3), P. 866 - 866

Published: Jan. 30, 2023

Colorectal cancer (CRC) is the second-leading cause of cancer-related deaths worldwide. While CRC thought to be an interplay between genetic and environmental factors, several lines evidence suggest involvement gut microbiota in promoting inflammation tumor progression. Gut refer ~40 trillion microorganisms that inhabit human gut. Advances next-generation sequencing technologies metagenomics have provided new insights into microbial ecology helped linking CRC. Many studies carried out humans animal models emphasized role certain bacteria, such as Fusobacterium nucleatum, enterotoxigenic Bacteroides fragilis, colibactin-producing Escherichia coli, onset progression Metagenomic opened up avenues for application diagnosis, prevention, treatment This review article summarizes development its use a biomarker predict disease potential therapeutic applications.

Language: Английский

Citations

71
Photo‐facilitated chemodynamic therapeutic agents: Synthesis, mechanisms, and biomedical applications DOI Creative Commons

Nan Yang,

Changyu Cao,

Xinyi Lv

et al.

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Feb. 16, 2023

Abstract Chemodynamic therapy (CDT) utilizes Fenton and/or Fenton‐like reactions in the tumor microenvironment (TME) to produce cytotoxic reactive oxygen species (ROS, mainly hydroxyl radicals, •OH) for inducing cancer cell death. Since CDT exhibits minimal invasiveness and high specificity by responding TME (overexpressed hydrogen peroxide (H 2 O ) glutathione (GSH) generation), a lot of related research has been conducted recently. Photo‐facilitated can further enhance catalytic activity controllability treatment. In addition, other photo‐induced therapies, including photodynamic photothermal (PDT, PTT), may synergize with obtain boosting treatment efficacy avoid multidrug resistance. this minireview, we summarize recent advances photo‐assisted CDT, PTT‐facilitated PDT‐facilitated CDT. More importantly, challenges encountered process are discussed potential development directions suggested facilitate clinical translation future.

Language: Английский

Citations

55