Acetyl-CoA metabolic accumulation promotes hepatocellular carcinoma metastasis via enhancing CXCL1-dependent infiltration of tumor-associated neutrophils DOI
Junjie Pan,

Sun‐Zhe Xie,

Xin Zheng

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 592, P. 216903 - 216903

Published: April 24, 2024

Language: Английский

NETscape or NEThance: tailoring anti-cancer therapy DOI Creative Commons
Alexandra Mousset,

Lola Bellone,

Cédric Gaggioli

et al.

Trends in cancer, Journal Year: 2024, Volume and Issue: 10(7), P. 655 - 667

Published: April 24, 2024

Neutrophils, major regulators of innate immunity, have recently emerged as key components the tumor microenvironment. The role neutrophils in cancer has been linked to their ability form neutrophil extracellular traps (NETs), structures composed decondensed DNA decorated with enzymes that are released into space. Here, we discuss pivotal roles NETs influencing responses anticancer therapies such chemotherapy, radiotherapy, immunotherapy, and targeted therapy. Highlighting recent insights, delve dual nature context treatments, examining potential either counteract or enhance treatment outcomes. Strategic targeting may be a promising avenue for crafting combination resistance treatments' efficacy.

Language: Английский

Citations

8
A Two-Pronged Delivery Strategy Disrupting Positive Feedback Loop of Neutrophil Extracellular Traps for Metastasis Suppression DOI

Jinxia Kong,

Yudi Deng, Yiwen Xu

et al.

ACS Nano, Journal Year: 2024, Volume and Issue: 18(24), P. 15432 - 15451

Published: June 6, 2024

Neutrophil extracellular traps (NETs) severely affect tumor metastasis through a self-perpetuating feedback loop involving two key steps: (1) mitochondrial aerobic respiration-induced hypoxia promotes NET formation and (2) NETs enhance metabolism to exacerbate hypoxia. Herein, we propose two-pronged approach with the activity of NET-degrading mitochondrion-damaging by simultaneously targeting drugs mitochondria this loop. In addition specifically recognizing eliminating extant NETs, NET-targeting nanoparticle also reduces NET-induced biogenesis, thus inhibiting initial step mitigating NETs' impact on metastasis. Simultaneously, mitochondrion-targeting system intercepts alleviates hypoxia, neutrophil infiltration subsequent formation, which source disrupts another self-amplifying Together, combination significantly NET–tumor cell clusters disrupting interaction between mitochondria, thereby impeding metastatic cascade including invasion, hematogenous spread, distant colonization. This work represents an innovative attempt disrupt in metastasis, offering promising therapeutic restraining NET-assisted

Language: Английский

Citations

8
Neutrophil extracellular traps in wound healing DOI
Zhanyong Zhu,

Shengzhi Zhou,

Sicheng Li

et al.

Trends in Pharmacological Sciences, Journal Year: 2024, Volume and Issue: 45(11), P. 1033 - 1045

Published: Oct. 16, 2024

Language: Английский

Citations

8
Neutrophils’ dual role in cancer: from tumor progression to immunotherapeutic potential DOI
Gujie Wu,

Binyang Pan,

Haochun Shi

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 140, P. 112788 - 112788

Published: July 30, 2024

Language: Английский

Citations

7
Acetyl-CoA metabolic accumulation promotes hepatocellular carcinoma metastasis via enhancing CXCL1-dependent infiltration of tumor-associated neutrophils DOI
Junjie Pan,

Sun‐Zhe Xie,

Xin Zheng

et al.

Cancer Letters, Journal Year: 2024, Volume and Issue: 592, P. 216903 - 216903

Published: April 24, 2024

Language: Английский

Citations

6