Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Chemical Reviews, Journal Year: 2021, Volume and Issue: 121(21), P. 13454 - 13619

Published: Sept. 28, 2021

This review presents a robust strategy to design photosensitizers (PSs) for various species. Photodynamic therapy (PDT) is photochemical-based treatment approach that involves the use of light combined with light-activated chemical, referred as PS. Attractively, PDT one alternatives conventional cancer due its noninvasive nature, high cure rates, and low side effects. PSs play an important factor in photoinduced reactive oxygen species (ROS) generation. Although concept photosensitizer-based photodynamic has been widely adopted clinical trials bioimaging, until now, our surprise, there no relevant article on rational designs organic PDT. Furthermore, most published articles focused nanomaterials nanotechnology based traditional PSs. Therefore, this aimed at reporting recent strategies develop innovative enhanced therapy, each example described detail instead providing only general overview, typically done previous reviews PDT, provide intuitive, vivid, specific insights readers.

Language: Английский

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Design of BODIPY dyes as triplet photosensitizers: electronic properties tailored for solar energy conversion, photoredox catalysis and photodynamic therapy

Chemical Science, Journal Year: 2021, Volume and Issue: 12(19), P. 6607 - 6628

Published: Jan. 1, 2021

BODIPYs are renowned fluorescent dyes with strong and tunable absorption in the visible region, high thermal photo-stability exceptional fluorescence quantum yields. Transition metal complexes most commonly used triplet photosensitisers, but, recently, use of organic has emerged as a viable more sustainable alternative. By proper design, BODIPY have been turned from highly labels into efficient photosensitizers region (from green to orange). In this perspective, we report three design strategies: (i) halogenation dye skeleton, (ii) donor-acceptor dyads (iii) dimers. We compare pros cons these approaches terms optical electrochemical properties synthetic viability. The potential applications systems span energy conversion medicine key examples presented.

Language: Английский

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Small molecular fluorescent probes for the detection of lead, cadmium and mercury ions

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 429, P. 213691 - 213691

Published: Dec. 19, 2020

Language: Английский

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Near-infrared (NIR) fluorescence-emitting small organic molecules for cancer imaging and therapy

Chemical Society Reviews, Journal Year: 2022, Volume and Issue: 51(21), P. 8957 - 9008

Published: Jan. 1, 2022

We discuss recent advances made in the development of NIR fluorescence-emitting small organic molecules for tumor imaging and therapy.

Language: Английский

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Photodynamic Therapy: A Compendium of Latest Reviews

Cancers, Journal Year: 2021, Volume and Issue: 13(17), P. 4447 - 4447

Published: Sept. 3, 2021

Photodynamic therapy (PDT) is a promising against cancer. Even though it has been investigated for more than 100 years, scientific publications have grown exponentially in the last two decades. For this reason, we present brief compendium of reviews decades classified under different topics, namely, overviews, about specific cancers, and meta-analyses photosensitisers, PDT mechanisms, dosimetry, light sources. The key issues main conclusions are summarized, including ways means to improve outcomes. Due broad scope work being first time that latest performed PDT, may be interest wide audience.

Language: Английский

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Enhanced photodynamic therapy for overcoming tumor hypoxia: From microenvironment regulation to photosensitizer innovation

Coordination Chemistry Reviews, Journal Year: 2020, Volume and Issue: 427, P. 213604 - 213604

Published: Oct. 12, 2020

Language: Английский

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Light Technology for Efficient and Effective Photodynamic Therapy: A Critical Review

Cancers, Journal Year: 2021, Volume and Issue: 13(14), P. 3484 - 3484

Published: July 13, 2021

Photodynamic therapy (PDT) is a cancer treatment with strong potential over well-established standard therapies in certain cases. Non-ionising radiation, localisation, possible repeated treatments, and stimulation of immunological response are some the main beneficial features PDT. Despite great potential, its application remains challenging. Limited light penetration depth, non-ideal photosensitisers, complex dosimetry, complicated implementations clinic limiting factors hindering extended use To surpass actual technological paradigms, radically new sources, light-based devices, advanced measurement innovative strategies under extensive investigation. The aim this review to highlight advantages/pitfalls, technical challenges opportunities PDT, focus on technologies for activation such as delivery systems. In vein, broad overview current status superficial, interstitial, deep PDT modalities-and critical sources their effects process-are presented. Insight into advancements remaining optical devices provided from physical bioengineering perspective.

Language: Английский

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Engineering of BODIPY-based theranostics for cancer therapy

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 476, P. 214908 - 214908

Published: Nov. 7, 2022

Language: Английский

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Research advances in BODIPY-assembled supramolecular photosensitizers for photodynamic therapy

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 496, P. 215367 - 215367

Published: Aug. 25, 2023

Language: Английский

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Recent Progress and Trends in X-ray-Induced Photodynamic Therapy with Low Radiation Doses

ACS Nano, Journal Year: 2022, Volume and Issue: 16(12), P. 19691 - 19721

Published: Nov. 15, 2022

The prominence of photodynamic therapy (PDT) in treating superficial skin cancer inspires innovative solutions for its congenitally deficient shadow penetration the visible-light excitation. X-ray-induced (X-PDT) has been proven to be a successful technique reforming conventional PDT deep-seated tumors by creatively utilizing penetrating X-rays as external excitation sources and witnessed rapid developments over past several years. Beyond proof-of-concept demonstration, recent advances X-PDT have exhibited trend minimizing X-ray radiation doses quite low values. As such, scintillating materials used bridge photosensitizers play significant role, do diverse well-designed irradiation modes smart strategies improving tumor microenvironment. Here this review, we provide comprehensive summary achievements highlight trending efforts using radiation. We first describe concept relationships with radiodynamic radiotherapy then dissect mechanism absorption conversion materials, reactive oxygen species evaluation X-PDT, side effects clinical concerns on Finally, discuss detailed overview progress regarding low-dose present perspectives possible translation. It is expected that pursuit will facilitate breakthroughs, both fundamentally clinically, effective treatment near future.

Language: Английский

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