Advanced Functional Materials,
Journal Year:
2022,
Volume and Issue:
33(1)
Published: Oct. 31, 2022
Abstract
Organic
light‐emitting
materials
in
the
near‐infrared
(NIR)
region
are
important
to
realize
next‐generation
lightweight
and
wearable
applications
bioimaging,
photodynamic
therapy,
telecommunications.
Inorganic
organometallic
expensive
toxic;
thus,
development
of
purely
organic
is
essential.
However,
highly
efficient
NIR
made
still
its
infancy.
Therefore,
this
review
outlines
molecular
design
strategies
for
developing
small‐molecule
with
high
emission
efficiency
that
can
overcome
energy‐gap
law
be
applied
devices.
After
briefly
reviewing
basic
knowledge
required
molecules,
representative
high‐efficiency
molecules
reported
over
past
5
years
classified
according
their
core
moieties,
design,
physical
properties,
luminescence
characteristics
analyzed.
Further,
perspective
outlook
regarding
provided.
Exploration,
Journal Year:
2022,
Volume and Issue:
2(2)
Published: Feb. 19, 2022
Abstract
Illumination
of
biological
events
with
near‐infrared
II
sub‐channel
(NIR‐IIb,
1500–1700
nm)
enhances
the
transparency
tissues,
which
is
very
attractive
for
deep
imaging.
Due
to
long‐wavelength,
reduces
optical
damage,
suppresses
autofluorescence,
and
obviates
light
scattering,
NIR‐IIb
nanoprobes
afford
tissue
penetration
unprecedented
spatiotemporal
resolution.
Hence,
imaging
facilitates
learning
decipherment
proceedings
in
living
organisms
astounding
high
clarity.
In
comparison
its
predecessors
visible‐near‐infrared
spectrum,
has
shown
great
potential
extrapolating
applications
clinical
studies.
However,
use
organic
fluorescent
(OFNPs)
region
still
rare
since
it
early
stages.
Thus,
herein
we
aim
survey
recent
development
different
nanomaterials
characteristics,
their
unique
photophysical
properties,
utilization
animal
models.
Further,
practical
researches
on
emission
transition
are
highlighted.
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(6), P. 4683 - 4703
Published: Jan. 31, 2024
Organic
fluorescent
molecules
with
emission
in
the
second
near-infrared
(NIR-II)
biological
window
have
aroused
increasing
investigation
cancer
phototheranostics.
Among
these
studies,
Benzobisthiadiazole
(BBT),
high
electron
affinity,
is
widely
utilized
as
acceptor
constructing
donor–acceptor–donor
(D-A-D)
structured
fluorophores
intensive
(NIR)
absorption
and
NIR-II
fluorescence.
Until
now,
numerous
BBT-based
dyes
been
employed
tumor
phototheranostics
due
to
their
exceptional
structure
tunability,
biocompatibility,
photophysical
properties.
This
review
systematically
overviews
research
progress
of
small
molecular
focuses
on
molecule
design
bioapplications.
First,
engineering
strategies
fine-tune
properties
high-performance
are
discussed
detail.
Then,
applications
optical
imaging
phototherapy
highlighted.
Finally,
current
challenges
future
prospects
also
summarized.
believed
significantly
promote
further
BBT-derived
for
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(31)
Published: May 21, 2024
Fluorescence
imaging
(FLI)-guided
phototheranostics
using
emission
from
the
second
near-infrared
(NIR-II)
window
show
significant
potential
for
cancer
diagnosis
and
treatment.
Clinical
imaging-used
polymethine
ionic
indocyanine
green
(ICG)
dye
is
widely
adopted
NIR
fluorescence
imaging-guided
photothermal
therapy
(PTT)
research
due
to
its
exceptional
photophysical
properties.
However,
ICG
has
limitations
such
as
poor
photostability,
low
conversion
efficiency
(PCE),
short-wavelength
peak,
liver-targeting
issues,
which
restrict
wider
use.
In
this
study,
two
derivatives
are
transformed
into
neutral
merocyanines
(mCy)
achieve
much-enhanced
performance
NIR-II
phototheranostics.
Initial
designs
of
dyes
similar
drawbacks
in
terms
photostability
performance.
One
modified
molecules,
mCy890,
shows
significantly
improved
stability,
an
peak
over
1000
nm,
a
high
PCE
51%,
all
considerably
outperform
ICG.
vivo
studies
demonstrate
that
nanoparticles
mCy890
can
effectively
accumulate
at
tumor
sites
guided
by
imaging.
This
provides
valuable
insights
development
enhanced
Small,
Journal Year:
2021,
Volume and Issue:
17(44)
Published: Aug. 11, 2021
Abstract
Precision
oncotherapy
can
remove
tumors
without
causing
any
apparent
iatrogenic
damage
or
irreversible
side
effects
to
normal
tissues.
Second
near‐infrared
(NIR‐II)
nanotheranostics
simultaneously
perform
diagnostic
and
therapeutic
modalities
in
a
single
nanoplatform,
which
exhibits
prominent
perspectives
tumor
precision
treatment.
Among
all
NIR‐II
nanotheranostics,
organic
have
shown
an
exceptional
promise
for
translation
clinical
treatment
than
inorganic
virtue
of
their
good
biocompatibility,
excellent
reproducibility,
desirable
excretion,
high
biosafety.
In
this
review,
recent
progress
with
the
integration
diagnosis
therapy
is
systematically
summarized,
focusing
on
theranostic
modes
performances.
Furthermore,
current
status
quo,
problems,
challenges
are
discussed,
aiming
provide
certain
guiding
significance
future
development
oncotherapy.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
60(33), P. 17797 - 17809
Published: March 12, 2021
In
recent
years,
polymeric
nanoparticles
(NPs)
have
become
increasingly
popular
for
in
vitro
and
vivo
bioimaging
because
of
their
excellent
versatility
exceptional
optical
properties.
Following
a
brief
introduction
on
fluorescence
photoacoustic
imaging,
as
well
the
merits
using
NPs
over
other
types
fluorescent
probes,
this
Minireview
gives
concise
summary
key
advances
made
years
(2017-2020)
use
imaging.
A
particular
focus
is
placed
various
strategies
used
enhanced
applications,
including
that
encapsulate
near-infrared
dyes,
aggregation-induced-emission
fluorogens,
cationic
dyes
doped
with
bulky
hydrophobic
counterions,
semiconducting
polymers.
Next,
current
limitations
some
these
NP
systems
are
summarized
potential
solutions
offered
to
overcome
them.
Finally,
critical
considerations
regard
design
given
future
sensing
applications.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
61(5)
Published: Nov. 22, 2021
Bacterial
infection
is
one
of
the
greatest
threats
to
public
health.
In
vivo
real-time
monitoring
and
effective
treatment
infected
sites
through
non-invasive
techniques,
remain
a
challenge.
Herein,
we
designed
Pt
