Multifunctional nanotheranostics for near infrared optical imaging-guided treatment of brain tumors

Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 190, P. 114536 - 114536

Published: Sept. 13, 2022

Language: Английский

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Fluorination Enhances NIR‐II Emission and Photothermal Conversion Efficiency of Phototheranostic Agents for Imaging‐Guided Cancer Therapy

Advanced Materials, Journal Year: 2022, Volume and Issue: 35(3)

Published: Oct. 27, 2022

Phototheranostics with second near-infrared (NIR-II) imaging and photothermal effect have become a burgeoning biotechnology for tumor diagnosis precise treatment. As important parameters of phototheranostic agents (PTAs), fluorescence quantum yield (QY) conversion efficiency (PCE) are usually considered as pair contradictions that is difficult to be simultaneously enhanced. Herein, fluorination strategy designing A-D-A type PTAs synchronously improved QY PCE proposed. Experimental results show the molar extinction coefficient (ε), NIR-II QY, all fluorinated nanoparticles (NPs) definitely compared chlorinated counterparts. Theoretical calculation demonstrate can maximize electrostatic potential difference by virtue high electronegativity fluorine, which may increase intra/intermolecular D-A interactions, tighten molecule packing, further promote ε, ultimately leading enhanced PCE. In these PTA NPs, FY6-NPs display emission extended 1400 nm highest (4.2%) (80%). These features make perform well in high-resolution vasculature imaging-guided therapy (PTT) tumors. This study develops valuable guideline constructing organic performance.

Language: Английский

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Recent progress in NIR-II fluorescence imaging-guided drug delivery for cancer theranostics

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114821 - 114821

Published: April 9, 2023

Language: Английский

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NIR-II light in clinical oncology: opportunities and challenges

Nature Reviews Clinical Oncology, Journal Year: 2024, Volume and Issue: 21(6), P. 449 - 467

Published: May 1, 2024

Language: Английский

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Recent advances in near-infrared-II hollow nanoplatforms for photothermal-based cancer treatment

Biomaterials Research, Journal Year: 2022, Volume and Issue: 26(1)

Published: Sept. 30, 2022

Near-infrared-II (NIR-II, 1000-1700 nm) light-triggered photothermal therapy (PTT) has been regarded as a promising candidate for cancer treatment, but PTT alone often fails to achieve satisfactory curative outcomes. Hollow nanoplatforms prove be attractive in the biomedical field owing merits including good biocompatibility, intrinsic physical-chemical nature and unique hollow structures, etc. On one hand, themselves can NIR-II agents (PTAs), cavities of which are able carry diverse therapeutic units realize multi-modal therapies. other PTAs capable decorating on surface combine with functions components encapsulated inside synergistic treatment. Notably, generally serve photoacoustic imaging (PAI) contrast (CAs), means such kind also expected multifunctional all-in-one nanotheranostics. In this review, recent advances single-modal PTT, dual-modal PTT/photodynamic (PDT), PTT/chemotherapy, PTT/catalytic PTT/gas well PTT/chemodynamic (CDT)/chemotherapy, PTT/chemo/gene PTT/PDT/CDT/starvation (ST)/immunotherapy summarized first time. Before these, typical synthetic strategies structures presented, lastly, potential challenges perspectives related these novel paradigms future research clinical translation discussed.

Language: Английский

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Engineered NIR-II fluorophores with ultralong-distance molecular packing for high-contrast deep lesion identification

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Aug. 18, 2023

The limited signal of long-wavelength near-infrared-II (NIR-II, 900-1880 nm) fluorophores and the strong background caused by diffused photons make high-contrast fluorescence imaging in vivo with deep tissue disturbed still challenging. Here, we develop NIR-II fluorescent small molecules aggregation-induced emission properties, high brightness, maximal beyond 1200 nm enhancing electron-donating ability reducing donor-acceptor (D-A) distance, to complement scarce bright emissive organic dyes. convincing single-crystal evidence D-A-D molecular structure reveals inhibition π-π stacking ultralong packing distance exceeding 8 Å. delicately-designed nanofluorophores signals extending 1900 match background-suppressed window, enabling signal-to-background ratio image reach over 100 thickness ~4-6 mm. In addition, intraluminal lesions negatively stained can be identified almost zero background. This method provide new avenues for future design biomedical highly scattering tissues.

Language: Английский

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NIR‐II absorbing organic nanoagents for photoacoustic imaging and photothermal therapy

BMEMat, Journal Year: 2023, Volume and Issue: 1(1)

Published: Jan. 30, 2023

Abstract Near‐infrared (NIR) absorbing materials hold great potential in biomedical applications, such as fluorescence imaging (FLI), photoacoustic (PAI), photodynamic therapy (PDT), and photothermal (PTT). Generally, these can be classified into two main categories based on their wavelengths: the first NIR (NIR‐I) (~650–950 nm) second (NIR‐II) (~1000–1700 materials. Due to reduced absorption scattering of NIR‐II light tissue compared NIR‐I light, enable with improved contrast deepened penetration, which is favor practical applications. Various inorganic have been developed for phototheranostics recent years. However, non‐biodegradability toxicity hinder further clinical translation. Biocompatible organic biodegradability well tailored optical property are thus more desired. In this review, we summarize advances nanoagents (ONAs) small molecules (SMs) conjugated polymers (CPs) PAI PTT show our perspectives future challenges development

Language: Английский

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Benzobisthiadiazole-Based Small Molecular Near-Infrared-II Fluorophores: From Molecular Engineering to Nanophototheranostics

ACS Nano, Journal Year: 2024, Volume and Issue: 18(6), P. 4683 - 4703

Published: Jan. 31, 2024

Organic fluorescent molecules with emission in the second near-infrared (NIR-II) biological window have aroused increasing investigation cancer phototheranostics. Among these studies, Benzobisthiadiazole (BBT), high electron affinity, is widely utilized as acceptor constructing donor–acceptor–donor (D-A-D) structured fluorophores intensive (NIR) absorption and NIR-II fluorescence. Until now, numerous BBT-based dyes been employed tumor phototheranostics due to their exceptional structure tunability, biocompatibility, photophysical properties. This review systematically overviews research progress of small molecular focuses on molecule design bioapplications. First, engineering strategies fine-tune properties high-performance are discussed detail. Then, applications optical imaging phototherapy highlighted. Finally, current challenges future prospects also summarized. believed significantly promote further BBT-derived for

Language: Английский

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Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

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Rationally Designed Benzobisthiadiazole‐Based Covalent Organic Framework for High‐Performance NIR‐II Fluorescence Imaging‐Guided Photodynamic Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(17)

Published: March 8, 2024

Although being applied as photosensitizers for photodynamic therapy, covalent organic frameworks (COFs) fail the precise fluorescence imaging in vivo and phototherapy deep-tissue, due to short excitation/emission wavelengths. Herein, this work proposes first example of NIR-II emissive benzobisthiadiazole-based COF-980. Comparing its ligands, structure COF-980 can more efficiently reducing energy gap (ΔE

Language: Английский

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