Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Abstract
Sonodynamic
therapy
(SDT)
as
an
emerging
method
for
cancer
has
encountered
difficulty
in
insufficient
production
of
reactive
oxygen
species
(ROS),
especially
tumor
microenvironment
(TME)
with
elevated
antioxidants
and
hypoxic
conditions.
In
this
work,
the
authors
have
fabricated
heterostructured
manganese
dioxide
(MnO
2
)‐coated
BaTiO
3
nanoparticles
(BTO@M
NPs)
a
piezoelectric
sonosensitizer,
which
exhibits
capacity
remodeling
TME
multienzyme‐like
catalysis
boosting
SDT.
Benefitting
from
piezotronic
effect,
formation
p
‐
n
junction
between
MnO
BTO
built‐in
electric
field
band
bending
efficiently
promotes
separation
charge
carriers,
facilitating
generation
superoxide
anion
(•O
−
)
hydroxyl
radical
(•OH)
under
ultrasound
(US)
stimulation.
Moreover,
BTO@M
NPs
can
catalyze
overexpressed
hydrogen
peroxide
(H
O
to
produce
replenishing
gas
source
SDT,
also
deplete
antioxidant
glutathione
(GSH),
realizing
remodeling.
During
process,
reduced
Mn(II)
convert
H
into
•OH,
further
amplifying
cellular
oxidative
damage.
With
these
combination
effects,
versatile
exhibit
prominent
cytotoxicity
growth
inhibition
against
4T1
breast
cancer.
This
work
provides
feasible
strategy
constructing
high‐efficiency
sonosensitizers
Small,
Journal Year:
2024,
Volume and Issue:
20(25)
Published: Jan. 15, 2024
Abstract
Sonodynamic
therapy
(SDT)
as
a
promising
non‐invasive
anti‐tumor
means
features
the
preferable
penetration
depth,
which
nevertheless,
usually
can't
work
without
sonosensitizers.
Sonosensitizers
produce
reactive
oxygen
species
(ROS)
in
presence
of
ultrasound
to
directly
kill
tumor
cells,
and
concurrently
activate
immunity
especially
after
integration
with
microenvironment
(TME)‐engineered
nanobiotechnologies
combined
therapy.
Current
sonosensitizers
are
classified
into
organic
inorganic
ones,
current
most
reviews
only
cover
highlighted
their
applications.
However,
there
have
few
specific
that
focus
on
including
design
principles,
regulation,
etc.
In
this
review,
first
according
rationales
rather
than
composition,
action
underlying
chemistry
highlighted.
Afterward,
what
how
TME
is
regulated
based
sonosensitizers‐based
SDT
nanoplatform
an
emphasis
targets‐engineered
elucidated.
Additionally,
applications
non‐cancer
diseases
also
outlined.
Finally,
setbacks
challenges,
proposed
potential
solutions
future
directions
pointed
out.
This
review
provides
comprehensive
detailed
horizon
sonosensitizers,
will
arouse
more
attentions
SDT.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(9)
Published: Jan. 12, 2024
With
the
rapid
development
of
external
minimally
invasive
or
noninvasive
therapeutic
modalities,
ultrasound-based
sonodynamic
therapy
(SDT)
is
a
new
alternative
for
treating
deep
tumors.
However,
inadequate
sonosensitizer
efficiency
and
poor
biosecurity
limit
clinical
applications.
In
this
study,
we
prepared
an
oxygen-vacancy-engineered
W
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(27)
Published: March 29, 2024
Cancer
treatment
requires
precise
tumor-specific
targeting
at
specific
sites
that
allows
for
high-resolution
diagnostic
imaging
and
long-term
patient-tailorable
cancer
therapy;
while,
minimizing
side
effects
largely
arising
from
non-targetability.
This
can
be
realized
by
harnessing
exogenous
remote
stimuli,
such
as
tissue-penetrative
ultrasound,
magnetic
field,
light,
radiation,
enable
local
activation
therapy
in
deep
tumors.
A
myriad
of
nanomedicines
efficiently
activated
when
the
energy
stimuli
transformed
into
another
type
energy.
review
discusses
control
transformation
targetable,
efficient,
therapy.
Such
ultrasonic,
magnetic,
photonic,
radiative,
radioactive
mechanical,
thermal,
chemical,
radiative
to
a
variety
modalities.
The
current
article
describes
multimodal
where
serial
cascade
or
multiple
types
occur.
includes
not
only
hyperthermia,
radiation
but
also
emerging
thermoelectric,
pyroelectric,
piezoelectric
therapies
treatment.
It
illustrates
resonance,
fluorescence,
computed
tomography,
photoluminescence,
photoacoustic
imaging-guided
therapies.
highlights
afterglow
eliminate
autofluorescence
sustained
signal
emission
after
excitation.
Small Methods,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 1, 2024
Abstract
Sonodynamic
therapy
(SDT)
as
an
emerging
method
for
cancer
has
encountered
difficulty
in
insufficient
production
of
reactive
oxygen
species
(ROS),
especially
tumor
microenvironment
(TME)
with
elevated
antioxidants
and
hypoxic
conditions.
In
this
work,
the
authors
have
fabricated
heterostructured
manganese
dioxide
(MnO
2
)‐coated
BaTiO
3
nanoparticles
(BTO@M
NPs)
a
piezoelectric
sonosensitizer,
which
exhibits
capacity
remodeling
TME
multienzyme‐like
catalysis
boosting
SDT.
Benefitting
from
piezotronic
effect,
formation
p
‐
n
junction
between
MnO
BTO
built‐in
electric
field
band
bending
efficiently
promotes
separation
charge
carriers,
facilitating
generation
superoxide
anion
(•O
−
)
hydroxyl
radical
(•OH)
under
ultrasound
(US)
stimulation.
Moreover,
BTO@M
NPs
can
catalyze
overexpressed
hydrogen
peroxide
(H
O
to
produce
replenishing
gas
source
SDT,
also
deplete
antioxidant
glutathione
(GSH),
realizing
remodeling.
During
process,
reduced
Mn(II)
convert
H
into
•OH,
further
amplifying
cellular
oxidative
damage.
With
these
combination
effects,
versatile
exhibit
prominent
cytotoxicity
growth
inhibition
against
4T1
breast
cancer.
This
work
provides
feasible
strategy
constructing
high‐efficiency
sonosensitizers
