A Forward Vision for Chemodynamic Therapy: Issues and Opportunities DOI
Peiran Zhao, Huiyan Li, Wenbo Bu

et al.

Angewandte Chemie, Journal Year: 2023, Volume and Issue: 135(7)

Published: Jan. 17, 2023

Abstract Since the insight to fuse Fenton chemistry and nanomedicine into cancer therapy, great signs of progress have been made in field chemodynamic therapy (CDT). However, exact mechanism CDT is obscured by unique tumor chemical environment inevitable nanoparticle‐cell interactions, thus impeding further development. In this Scientific Perspective, significance clarified, complex deconstructed primitive biological research directions based on kinetics signaling pathways are discussed detail. Moreover, beneficial outlooks presented enlighten evolution next‐generation CDT. Hopefully, Perspective can inspire new ideas advances for provide a reference breaking down interdisciplinary barriers nanomedicine.

Language: Английский

Atomic Engineering of Single‐Atom Nanozymes for Biomedical Applications DOI

Ji Shen,

Jian Chen, Yuping Qian

et al.

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(21)

Published: Feb. 7, 2024

Single-atom nanozymes (SAzymes) showcase not only uniformly dispersed active sites but also meticulously engineered coordination structures. These intricate architectures bestow upon them an exceptional catalytic prowess, thereby captivating numerous minds and heralding a new era of possibilities in the biomedical landscape. Tuning microstructure SAzymes on atomic scale is key factor designing targeted with desirable functions. This review first discusses summarizes three strategies for their impact reactivity biocatalysis. The effects choices carrier, different synthesis methods, modulation first/second shell, type number metal centers enzyme-like activity are unraveled. Next, attempt made to summarize biological applications tumor therapy, biosensing, antimicrobial, anti-inflammatory, other from mechanisms. Finally, how designed regulated further realization diverse reviewed prospected. It envisaged that comprehensive presented within this exegesis will furnish novel perspectives profound revelations regarding SAzymes.

Language: Английский

Citations

50
Pore Space Partition Approach of ZIF-8 for pH Responsive Codelivery of Ursolic Acid and 5-Fluorouracil DOI
Ziqi Zhou,

Qiaomei Ke,

Manni Wu

et al.

ACS Materials Letters, Journal Year: 2023, Volume and Issue: 5(2), P. 466 - 472

Published: Jan. 13, 2023

Metal–organic frameworks are smart carriers for controlled drug delivery due to large surface area and adjustable pore size. Current approaches can hardly utilize the space of MOFs thoroughly, greatly causing waste space. Here, Pore Space Partition (PSP) approach was employed achieve effective encapsulation pH-controlled codelivery two guest molecules. The ZIF-8 partitioned by molecule ursolic acid (UA), remaining filled with small 5-fluorouracil (5-FU), obtaining 5-FU&UA@ZIF-8 high loading capacity UA (12.80 wt %) 5-FU (11.20 %). Accompanied collapse in acidic surroundings, exhibited delivery. To our surprise, also showed pH responsive delivery, which did not exist before partition UA. Codelivery enable have good anticancer performance against 4T1 cells.

Language: Английский

Citations

49
Hydrogen Sulfide Gas Amplified ROS Cascade: FeS@GOx Hybrid Nanozyme Designed for Boosting Tumor Chemodynamic Immunotherapy DOI

Wanying Sun,

Chengyuan Zhu,

Juan Song

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(23)

Published: April 11, 2023

Chemodynamic immunotherapy that utilizes catalysts to produce reactive oxygen species (ROS) for killing tumor cells and arousing antitumor immunity has received considerable attention. However, it is still restricted by low ROS production efficiency insufficient immune activation, due intricate redox homeostasis in the microenvironment (TME). Herein, a metalloprotein-like hybrid nanozyme (FeS@GOx) designed situ growth of (ferrous sulfide, FeS) natural enzyme (glucose oxidase, GOx) amplify cascade boosting chemodynamic immunotherapy. In FeS@GOx, GOx allows conversion endogenous glucose gluconic acid hydrogen peroxide, which provides favorable increasing peroxide subsequent Fenton reaction FeS nanozymes, thus reinforcing production. Notably, sulfide (H2 S) release activated generation-related pH decrease, can suppress activity thioredoxin reductase catalase further inhibit elimination. Thus, FeS@GOx sustainably accumulation perturb intracellular improve therapy trigger robust immunogenic cell death effective combined with checkpoint blockade. This work proposes feasible H2 S amplified strategy employing bioinspired nanozyme, providing novel pathway multi-enzyme-mediated TME modulation precise efficient

Language: Английский

Citations

47
Doxorubicin-Fe(III)-Gossypol Infinite Coordination Polymer@PDA:CuO2 Composite Nanoparticles for Cost-Effective Programmed Photothermal-Chemodynamic-Coordinated Dual Drug Chemotherapy Trimodal Synergistic Tumor Therapy DOI
Hongrui Zhu,

Chenqi Huang,

Jingran Di

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(13), P. 12544 - 12562

Published: June 24, 2023

To achieve the maximum therapeutic effects and minimize adverse of trimodal synergistic tumor therapies, a cost-effective programmed photothermal (PTT)-chemodynamic (CDT)-coordinated dual drug chemotherapy (CT) therapy strategy in chronological order is proposed. According to status or volumes tumors, intensity time each modality are optimized, three modalities combined programmatically work order. The optimal begins with high-intensity PTT for 10 min ablate larger followed by medium-intensity CDT several hours eliminate medium-sized then low-intensity coordinated drugs CT lasts over 48 h clear smaller residual tumors. Composite nanoparticles, made Fe-coordinated polydopamine mixed copper peroxide as cores their surface dotted lots doxorubicin-Fe(III)-gossypol infinite coordination polymers (ICPs), have been developed implement strategy. These composite nanoparticles show excellent minimum dose agents result nearly 100% inhibition mice bearing PC-3 tumors no observed recurrence within 60 days treatment. ratios different can be adjusted accommodate types this

Language: Английский

Citations

43
Current advances in metal–organic frameworks for cancer nanodynamic therapies DOI

Zhu Liu,

Ziwei Yan,

Yifan Di

et al.

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215434 - 215434

Published: Sept. 17, 2023

Language: Английский

Citations

43
Near-infrared-driven upconversion nanoparticles with photocatalysts through water-splitting towards cancer treatment DOI
Pranjyan Dash, Pradeep Kumar Panda,

Chaochin Su

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(16), P. 3881 - 3907

Published: Jan. 1, 2024

Water splitting is promising, especially for energy and environmental applications; however, there are limited studies on the link between water cancer treatment. Upconversion nanoparticles (UCNPs) can be used to convert near-infrared (NIR) light ultraviolet (UV) or visible (Vis) have great potential biomedical applications because of their profound penetration ability, theranostic approaches, low self-fluorescence background, reduced damage biological tissue, toxicity. UCNPs with photocatalytic materials enhance activities that generate a shorter wavelength increase tissue depth in microenvironment under NIR irradiation. Moreover, photosensitizer absorb it into UV/vis emit upconverted photons, which excite photoinitiator create H

Language: Английский

Citations

17
Design of oxide nanoparticles for biomedical applications DOI
Bowon Lee, Yun‐Jung Lee, Jeong Yong Lee

et al.

Nature Reviews Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

2
Hybrid Ag nanoparticles/polyoxometalate-polydopamine nano-flowers loaded chitosan/gelatin hydrogel scaffolds with synergistic photothermal/chemodynamic/Ag+ anti-bacterial action for accelerated wound healing DOI
Kunpeng Zhou,

Zhengchao Zhang,

Jingwen Xue

et al.

International Journal of Biological Macromolecules, Journal Year: 2022, Volume and Issue: 221, P. 135 - 148

Published: Aug. 25, 2022

Language: Английский

Citations

64
Tumor microenvironment-activated single-atom platinum nanozyme with H2O2 self-supplement and O2-evolving for tumor-specific cascade catalysis chemodynamic and chemoradiotherapy DOI Creative Commons
Qiqi Xu,

Yuetong Zhang,

Zulu Yang

et al.

Theranostics, Journal Year: 2022, Volume and Issue: 12(11), P. 5155 - 5171

Published: Jan. 1, 2022

Nanozyme-based tumor collaborative catalytic therapy has attracted a great deal of attention in recent years.However, their cooperative outcome remains challenge due to the unique characteristics microenvironment (TME), such as insufficient endogenous hydrogen peroxide (H2O2) level, hypoxia, and overexpressed intracellular glutathione (GSH).Methods: Herein, TME-activated atomic-level engineered PtN4C single-atom nanozyme (PtN4C-SAzyme) is fabricated induce "butterfly effect" reactive oxygen species (ROS) through facilitating H2O2 cycle accumulation GSH deprivation well X-ray deposition for ROS-involving CDT O2-dependent chemoradiotherapy.Results: In paradigm, SAzyme could boost substantial •OH generation by admirable peroxidase-like activity capacity.Simultaneously, O2 self-sufficiency, elimination elevated Pt 2+ release can be achieved self-cyclic valence alteration (IV) (II) alleviating overwhelming anti-oxidation defense effect overcoming drug-resistance.More importantly, PtN4C-SAzyme also convert •-into superior superoxide dismutase-like achieve sustainable replenishment H2O2, further react with realizing cyclic at site, thereby generating "key" unlock multi enzymes-like properties SAzymes tumor-specific self-reinforcing chemoradiotherapy.Conclusions: This work not only provides promising SAzyme-based paradigm self-supplement O2-evolving capacity intensive chemoradiotherapy but opens new horizons construction other SAzymes.

Language: Английский

Citations

56
Recent advances in augmenting Fenton chemistry of nanoplatforms for enhanced chemodynamic therapy DOI
Shulan Li, Xu Chu, Hongli Dong

et al.

Coordination Chemistry Reviews, Journal Year: 2022, Volume and Issue: 479, P. 215004 - 215004

Published: Dec. 31, 2022

Language: Английский

Citations

55