Multienzyme‐Like Nanozymes: Regulation, Rational Design, and Application

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(10)

Published: Feb. 25, 2023

Nanomaterials with more than one enzyme-like activity are termed multienzymic nanozymes, and they have received increasing attention in recent years hold huge potential to be applied diverse fields, especially for biosensing therapeutics. Compared single nanozymes offer various unique advantages, including synergistic effects, cascaded reactions, environmentally responsive selectivity. Nevertheless, along these merits, the catalytic mechanism rational design of complicated elusive as compared single-enzymic nanozymes. In this review, classification scheme based on numbers/types activities, internal external factors regulating multienzymatic chemical, biomimetic, computer-aided strategies, progress applications attributed advantages multicatalytic activities systematically discussed. Finally, current challenges future perspectives regarding development application suggested. This review aims deepen understanding inspire research a greater extent.

Language: Английский

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Multifunctional nanomedicines-enabled chemodynamic-synergized multimodal tumor therapy via Fenton and Fenton-like reactions

Theranostics, Journal Year: 2023, Volume and Issue: 13(6), P. 1974 - 2014

Published: Jan. 1, 2023

Chemodynamic therapy (CDT) is well-known for using the tumor microenvironment to activate Fenton reaction or Fenton-like generate strong oxidative hydroxyl radicals tumor-specific treatment. It highly selective and safe, without depth limitation of tissue penetration, shows its potential as a new green therapeutic method with great clinical application. However, catalytic efficiency reagents involved in severely affected by inherent microenvironmental limitations tumors strict reaction-dependent conditions. With increasing application nanotechnology medical field, combined therapies based on different types functional nanomaterials have opened up avenues development next-generation CDT-enhanced system. This review will comprehensively exemplify representative results CDT other antitumor such chemotherapy, phototherapy, sonodynamic therapy, radiation magnetic hyperthermia immunotherapy, starvation gas gene oncosis combination thereof improving from hundreds latest literature, introduce strategies ingenious design nanomedicines regulations enhance further summarize challenges future perspective CDT-based multimodal anticancer therapy.

Language: Английский

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Single‐Atom Nanozymes for Catalytic Therapy: Recent Advances and Challenges

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: 34(16)

Published: Jan. 4, 2024

Abstract As a powerful tool, nanozyme catalysts broaden the avenues to implement bio‐inspired solutions for addressing many important concerns, covering energy, healthcare, environment, and more. Recent endeavors, characterized by atomic precision, have enabled extensive exploration of single‐atom nanozymes (SAzymes) with high catalytic activity, superior substrate selectivity, integrated multifunctionalities, thus becoming an emerging field that bridges nanotechnology biology. This review provides brief outline progress summarizes latest research advances regarding SAzymes in biomedical therapeutics, mainly including tumor therapy, wound antibacterial tissue anti‐inflammatory focus on their prototypical synthesis therapeutic mechanisms. Finally, current challenges future perspectives engineering advanced are also discussed outlooked. It is anticipated this area shall provide useful guidance therapy.

Language: Английский

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Current advances in metal–organic frameworks for cancer nanodynamic therapies

Coordination Chemistry Reviews, Journal Year: 2023, Volume and Issue: 497, P. 215434 - 215434

Published: Sept. 17, 2023

Language: Английский

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Metal‐Organic Frameworks (MOFs): Classification, Synthesis, Modification, and Biomedical Applications

Small, Journal Year: 2024, Volume and Issue: 20(47)

Published: Aug. 16, 2024

Abstract Metal‐organic frameworks (MOFs) are a new variety of solid crystalline porous functional materials. As an extension inorganic materials, it has made important progress in preparation and application. MOFs widely used various fields such as gas adsorption storage, drug delivery, sensing, biological imaging due to their high specific surface area, porosity, adjustable pore size, abundant active sites, modification by introducing groups. In this paper, the types classified, synthesis methods mechanisms materials summarized. Finally, application prospects challenges metal‐organic framework biomedical field discussed, hoping promote multidisciplinary fields.

Language: Английский

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Single-Atom-Based Nanoenzyme in Tissue Repair

ACS Nano, Journal Year: 2024, Volume and Issue: 18(20), P. 12639 - 12671

Published: May 8, 2024

Since the discovery of ferromagnetic nanoparticles Fe3O4 that exhibit enzyme-like activity in 2007, research on nanoenzymes has made significant progress. With in-depth study various and rapid development related nanotechnology, have emerged as a promising alternative to natural enzymes. Within nanozymes, there is category metal-based single-atom nanozymes been rapidly developed due low cast, convenient preparation, long storage, less immunogenicity, especially higher efficiency. More importantly, possess capacity scavenge reactive oxygen species through mechanisms, which beneficial tissue repair process. Herein, this paper systemically highlights types metal their catalytic recent applications repair. The existing challenges are identified prospects future composed metallic nanomaterials proposed. We hope review will illuminate potential repair, encouraging sequential clinical translation.

Language: Английский

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Rational Design of Nanozymes for Engineered Cascade Catalytic Cancer Therapy

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Nanozymes have shown significant potential in cancer catalytic therapy by strategically catalyzing tumor-associated substances and metabolites into toxic reactive oxygen species (ROS) situ, thereby inducing oxidative stress promoting cell death. However, within the complex tumor microenvironment (TME), rational design of nanozymes factors like activity, reaction substrates, TME itself significantly influence efficiency ROS generation. To address these limitations, recent research has focused on exploring that affect activity developing nanozyme-based cascade systems, which can trigger two or more processes tumors, producing therapeutic achieving efficient stable with minimal side effects. This area remarkable progress. Perspective provides a comprehensive overview nanozymes, covering their classification fundamentals. The regulation nanozyme strategies are discussed detail. Furthermore, representative paradigms for successful construction systems treatment summarized focus revealing underlying mechanisms. Finally, we current challenges future prospects development biomedical applications.

Language: Английский

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Metal‐Based Nanozymes with Multienzyme‐Like Activities as Therapeutic Candidates: Applications, Mechanisms, and Optimization Strategy

Small, Journal Year: 2022, Volume and Issue: 19(7)

Published: Dec. 13, 2022

Most nanozymes in development for medical applications only exhibit single-enzyme-like activity, and are thus limited by insufficient catalytic activity dysfunctionality complex pathological microenvironments. To overcome the impediments of substrate availabilities concentrations, some metal-based may mimic two or more activities natural enzymes to catalyze cascade reactions multiple substrates simultaneously, thereby amplifying catalysis. Metal-based with multienzyme-like (MNMs) adapt dissimilar conditions exert different enzyme-like effects. These can synergize realize "self-provision substrate," which upstream catalysts produce downstream limitation microenvironment. Consequently, MNMs potent antitumor, antibacterial, anti-inflammatory effects preclinical models. This review summarizes cellular underlying mechanisms MNMs. Their potential utility optimization strategy from perspective clinical requirements also discussed, aim provide a theoretical reference design, development, therapeutic application their

Language: Английский

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Reactive oxygen species-upregulating nanomedicines towards enhanced cancer therapy

Biomaterials Science, Journal Year: 2022, Volume and Issue: 11(4), P. 1182 - 1214

Published: Dec. 20, 2022

A review of the recent progress ROS-upgrading nanosystems in oncotherapy is presented.

Language: Английский

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Bimetallic oxide Cu–Fe3O4 nanoclusters with multiple enzymatic activities for wound infection treatment and wound healing

Acta Biomaterialia, Journal Year: 2023, Volume and Issue: 173, P. 403 - 419

Published: Oct. 30, 2023

Language: Английский

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