Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 375, P. 331 - 345
Published: Sept. 17, 2024
Language: Английский
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 662, P. 171 - 182
Published: Feb. 8, 2024
Language: Английский
Citations
13
Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 5, 2024
Abstract Sonodynamic therapy (SDT) represents a promising, noninvasive, and precise treatment modality for tumors, demonstrating significant potential in clinical applications. However, the efficiency of sonosensitizers generating reactive oxygen species (ROS) is often limited by rapid electron‐hole recombination. In this study, BiF 3 @BiOI synthesized via co‐precipitation method, followed in‐situ reduction to decorate it with Pt nanoparticles, resulting @BiOI@Pt‐PVP (BBP) nanocomposite enhancing SDT efficacy. The formation heterojunction enhances charge separation ability. decoration nanoparticles narrows bandgap alters band positions Fermi level BBP, which can effectively mitigate recombination pairs facilitate cascade reaction ROS, thereby improving ROS generation ultrasound excitation. Additionally, bismuth ions BBP generated holes consume glutathione, exacerbating cellular oxidative damage, triggering PANoptosis ferroptosis. Furthermore, demonstrate peroxidase‐like activity, catalyzing endogenous hydrogen peroxide oxygen. These functions are helpful against tumors alleviating hypoxic conditions, reshaping microenvironment, modulating immune cell infiltration capacity, efficacy immunotherapy. dual strategy forming heterojunctions sensitization noble metals sono‐catalytic therapy‐induced activation tumor treatment.
Language: Английский
Citations
10
Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 523, P. 216282 - 216282
Published: Oct. 22, 2024
Language: Английский
Citations
9
Advanced Science, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 8, 2025
Hydrogen therapy has shown new potential in cancer treatment, particularly high-pressure and hypoxic areas, where it demonstrates the ability to alter tumor microenvironment regulate metabolism. disrupts mitochondrial function of cells, interferes with their energy metabolism, ultimately leads depletion apoptosis. In this study, a sonocatalyst (BPM), is designed generate hydrogen oxygen situ within tumors, further enhancing therapeutic efficacy. The mesocrystalline structure BPM, composed bismuth fluoride, polyoxometalates, molybdenum carbide, significantly improves charge separation electron transfer efficiency under ultrasound irradiation, resulting an efficient water-splitting reaction. By simultaneously generating depleting glutathione, BPM effectively triggers oxidative stress alleviates hypoxia, thereby disrupting inhibiting metabolism cells. Additionally, enhances antitumor immune responses by promoting dendritic cell maturation, activating T lymphocytes, polarizing macrophages toward M1 phenotype, reversing immunosuppressive state microenvironment. results indicate that holds for gas-immunotherapy combination treatments, offering multifunctional strategy improve outcomes.
Language: Английский
Citations
1
Nano Letters, Journal Year: 2025, Volume and Issue: unknown
Published: March 6, 2025
Biofilms significantly impede the efficacy of conventional antimicrobial agents, particularly in multidrug-resistant (MDR) infections. In this work, we developed a size-adaptive, bismuth-based nanomicrobicide encapsulated with neutrophil membranes (Bi2S3/SNP@CM), designed to selectively generate nitric oxide (NO) within acidic biofilms under near-infrared (NIR) irradiation. The nanomicrobicide's adaptive size ensures deeper biofilm penetration and accumulation, while membrane coating enhances biocompatibility targeting at infection sites. Upon NIR irradiation, localized heating NO release synergistically eradicate MDR biofilms. Furthermore, interactions between glutathione, as well reactions ROS, disrupt intracellular redox balance, further amplifying antibacterial efficacy. This innovative design affords promising for effectively treating
Language: Английский
Citations
1
Journal of Materials Chemistry C, Journal Year: 2023, Volume and Issue: 12(5), P. 1609 - 1624
Published: Dec. 22, 2023
In recent years, bismuth-based semiconductors have become a research hotspot in the new semiconductor field due to their unique optical and electronic properties.
Language: Английский
Citations
23
Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 679, P. 214 - 223
Published: Sept. 29, 2024
Language: Английский
Citations
7
Chemical Engineering Journal, Journal Year: 2023, Volume and Issue: 477, P. 147056 - 147056
Published: Nov. 1, 2023
Language: Английский
Citations
15
Biomaterials, Journal Year: 2024, Volume and Issue: 315, P. 122962 - 122962
Published: Nov. 12, 2024
Language: Английский
Citations
6
Dalton Transactions, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
The use of bismuth and its compounds in biomedicine has developed rapidly recent years. Due to their unique properties, there are great opportunities for the development new non-invasive strategies early diagnosis effective treatment cancers. This perspective highlights key fabrication methods generate well-defined clinically relevant materials varying characteristics. On one hand, this opens up a wide range possibilities unimodal multimodal imaging. other strategies, which increasingly based on combinatorial therapies, given deal attention. One biggest challenges remains selective tumour targeting, whether active or passive. Here we present an overview developments moving forward from simple enrichment at site via uptake by mononuclear phagocytic system (MPS) more specific targeting covalent modification with tumour-seeking molecules either small antibody-derived molecules.
Language: Английский
Citations
0