Reactive Oxygen Species-Responsive Gel-Based Microneedle Patches for Prolonged and Intelligent Psoriasis Management

ACS Nano, Journal Year: 2023, Volume and Issue: 17(5), P. 4346 - 4357

Published: Feb. 27, 2023

Psoriasis is an inflammatory skin disease. Microneedle (MN) patches can improve psoriasis treatment outcomes by increasing local drug content in the skin. As frequently relapses, developing intelligent MN-based delivery systems with prolonged therapeutic levels and improved efficiency of great significance. Here, we designed detachable H2O2-responsive gel-based MN containing methotrexate (MTX) epigallocatechin gallate (EGCG) using EGCG as both cross-linkers for needle-composited materials anti-inflammatory drugs. The MNs had dual-mode release kinetics, which quickly released MTX diffusively sustainably way. Compared dissolving MNs, extended retention EGCG, leading to reactive oxygen species (ROS) scavenging effects. ROS-responsive that transdermally delivered antiproliferative drugs psoriasis-like prophylactic animal models.

Language: Английский

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Engineering polyphenol-based polymeric nanoparticles for drug delivery and bioimaging

Chemical Engineering Journal, Journal Year: 2022, Volume and Issue: 439, P. 135661 - 135661

Published: March 7, 2022

Language: Английский

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Recent Advances in 3D Printing of Smart Scaffolds for Bone Tissue Engineering and Regeneration

Advanced Materials, Journal Year: 2024, Volume and Issue: 36(34)

Published: June 11, 2024

The repair and functional reconstruction of bone defects resulting from severe trauma, surgical resection, degenerative disease, congenital malformation pose significant clinical challenges. Bone tissue engineering (BTE) holds immense potential in treating these defects, without incurring prevalent complications associated with conventional autologous or allogeneic grafts. 3D printing technology enables control over architectural structures at multiple length scales has been extensively employed to process biomimetic scaffolds for BTE. In contrast inert grafts, next-generation smart possess a remarkable ability mimic the dynamic nature native extracellular matrix (ECM), thereby facilitating regeneration. Additionally, they can generate tailored controllable therapeutic effects, such as antibacterial antitumor properties, response exogenous and/or endogenous stimuli. This review provides comprehensive assessment progress 3D-printed BTE applications. It begins an introduction physiology, followed by overview technologies utilized scaffolds. Notable advances various stimuli-responsive strategies, efficacy, applications are discussed. Finally, highlights existing challenges development implementation scaffolds, well emerging this field.

Language: Английский

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Melatonin-Derived Carbon Dots with Free Radical Scavenging Property for Effective Periodontitis Treatment via the Nrf2/HO-1 Pathway

ACS Nano, Journal Year: 2024, Volume and Issue: 18(11), P. 8307 - 8324

Published: March 4, 2024

Periodontitis is a chronic inflammatory disease closely associated with reactive oxygen species (ROS) involvement. Eliminating ROS to control the periodontal microenvironment and alleviate response could potentially serve as an efficacious therapy for periodontitis. Melatonin (MT), renowned its potent antioxidant anti-inflammatory characteristics, frequently employed scavenger in diseases. However, therapeutic efficacy of MT remains unsatisfactory due low water solubility poor bioavailability. Carbon dots have emerged promising innovative nanomaterial facile synthesis, environmental friendliness, cost. In this study, melatonin-derived carbon (MT-CDs) were successfully synthesized via hydrothermal method. The MT-CDs good biocompatibility feature excellent ROS-scavenging capacity without additional modification. vitro experiments proved that efficiently regulated intracellular ROS, which maintained mitochondrial homeostasis suppressed production mediators. Furthermore, findings from mouse model periodontitis indicated significantly inhibited deterioration alveolar bone reduced osteoclast activation inflammation, thereby contributing regeneration damaged tissue. terms mechanism, may scavenge preventing cellular damage factors by regulating nuclear factor erythroid 2-related 2 (Nrf2)/heme oxygenase-1 (HO-1) pathway. will offer vital understanding advancement secure effective platforms more biomedical applications.

Language: Английский

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Co-encapsulation of Lactobacillus plantarum and EGCG: A promising strategy to increase the stability and lipid-lowering activity

Food Hydrocolloids, Journal Year: 2024, Volume and Issue: 151, P. 109768 - 109768

Published: Jan. 18, 2024

Language: Английский

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Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3273 - 3301

Published: Jan. 1, 2024

Oral diseases are prevalent but challenging owing to the highly movable and wet, microbial inflammatory environment. Polymeric materials regarded as one of most promising biomaterials due their good compatibility, facile preparation, flexible design obtain multifunctionality. Therefore, a variety strategies have been employed develop with improved therapeutic efficacy by overcoming physicobiological barriers in oral diseases. In this review, we summarize polymeric for treatment First, present unique environment including environment, which hinders effective Second, series designing towards such highlighted. For example, multifunctional armed wet-adhesive, antimicrobial, anti-inflammatory functions through advanced chemistry nanotechnology effectively treat These achieved wet-adhesive polymers modified hydroxy, amine, quinone, aldehyde groups provide strong wet-adhesion hydrogen covalent bonding, electrostatic hydrophobic interactions, developing antimicrobial cationic polymers, peptides, antibiotic-conjugated synthesizing phenolic hydroxy cysteine that function immunomodulators electron donors reactive oxygen species reduce inflammation. Third, various delivery systems enhanced mucosa biofilm penetration capabilities, nanoparticles, hydrogels, patches, microneedles, constructed antibiotics, immunomodulators, antioxidants achieve efficacy. Finally, insights into challenges future development promise clinical translation.

Language: Английский

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Antimicrobial Phenolic Materials: From Assembly to Function

Angewandte Chemie International Edition, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Abstract Infectious diseases pose considerable challenges to public health, particularly with the rise of multidrug‐resistant pathogens that globally cause high mortality rates. These can persist on surfaces and spread in healthcare settings. Advances have been made developing antimicrobial materials reduce transmission pathogens, including composed naturally sourced polyphenols their derivatives, which exhibit potency, broad‐spectrum activity, a lower likelihood promoting resistance. This review provides an overview recent advances fabrication phenolic biomaterials, where natural compounds act as active agents or encapsulate other (e.g., metal ions, peptides, biopolymers). Various forms biomaterials synthesized through these two strategies, particles, capsules, hydrogels, coatings, are summarized, focus application wound healing, bone repair regeneration, oral coatings for medical devices. The potential advanced promising therapeutic approach combating antimicrobial‐resistant infections reducing microbial transmission.

Language: Английский

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Injectable oxidized alginate/carboxylmethyl chitosan hydrogels functionalized with nanoparticles for wound repair

Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 293, P. 119733 - 119733

Published: June 14, 2022

Language: Английский

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ROS-scavenging biomaterials for periodontitis

Journal of Materials Chemistry B, Journal Year: 2022, Volume and Issue: 11(3), P. 482 - 499

Published: Nov. 21, 2022

Periodontitis is defined as a chronic inflammatory disease in which the continuous activation of oxidative stress surpasses reactive oxygen species (ROS) scavenging capacity endogenous antioxidative defense system. Studies have demonstrated that ROS-scavenging biomaterials should be promising candidates for periodontitis therapy. To benefit understanding and design periodontitis, this review details relationship between ROS including direct indirect damage, application organic inorganic biomaterials, various dosage forms fabricated materials currently used periodontal Finally, current situation further prospects applications are summarized. Expecting improved could better designed developed even clinical application.

Language: Английский

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Glutathione‐Induced In Situ Michael Addition between Nanoparticles for Pyroptosis and Immunotherapy

Angewandte Chemie International Edition, Journal Year: 2023, Volume and Issue: 62(20)

Published: March 20, 2023

Most tumor treatments will fail when ignoring competition and cooperation between each cancer cell its microenvironment. Inspired by game theory, therapeutic agents can be introduced to compete for intracellular molecules disrupt the cells. Biomineralized oxidized (-)-epigallocatechin-3-o-gallate (EGCG)-molybdenum ion coordination nanoparticles were prepared disrupting redox equilibria simultaneously reacting with GSH in a Michael addition form large aggregates that mechanically endosomal plasma membranes, stimulating pyroptosis anti-tumor immunological responses versatile inhibition of different types tumors. This design disrupts immune cells, achieving an optimal payoff therapy.

Language: Английский

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