Structurally Oriented Carbon Dots as ROS Nanomodulators for Dynamic Chronic Inflammation and Infection Elimination

ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 22055 - 22070

Published: Aug. 8, 2024

The selective elimination of cytotoxic ROS while retaining essential ones is pivotal in the management chronic inflammation. Co-occurring bacterial infection further complicates conditions, necessitating precision and an efficacious treatment strategy. Herein, dynamic nanomodulators are rationally constructed through regulating surface states herbal carbon dots (CDs) for on-demand inflammation or elimination. phenolic OH containing CDs derived from honeysuckle (HOCD) dandelion (DACD) demonstrated appropriate redox potentials, ensuring their ability to scavenge such as ·OH ONOO–, invalidity toward O2·–, H2O2, NO. This enables efficient without affecting signal pathways. C–N/C═N taxus leaves (TACD) DACD renders them with suitable band structures, facilitating absorption red region generation O2·– upon light irradiation sterilization. Specifically, facilely prepared demonstrates fascinating modulating ability, making it highly addressing concurrent infection, diabetic wound infection. regulation strategy facilitates realization precise minimal side effects, holding immense potential clinical practice.

Language: Английский

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Carbon Dots with Integrated Photothermal Antibacterial and Heat‐Enhanced Antioxidant Properties for Diabetic Wound Healing

Small, Journal Year: 2024, Volume and Issue: 20(45)

Published: July 25, 2024

Abstract Diabetic wounds pose a persistent challenge due to their slow healing nature, primarily caused by bacterial infection and excessive reactive oxygen species (ROS)‐induced inflammation. In this study, carbon dots with synergistic antibacterial antioxidant properties, referred as AA‐CDs, are developed specifically for diabetic wound using straightforward solvothermal method. By utilizing cost‐effective precursors like citric acid ascorbic acid, AA‐CDs engineered possess tailored functions of photothermal sterilization ROS scavenging. The resulting demonstrats broad‐spectrum activity, particularly against multidrug‐resistant strains, along efficient scavenging both in solution within cells. Additionally, exhibits protective effect oxidative stress‐induced damage. Notably, high conversion efficiency (41.18%), displays heat‐enhanced performance, providing not only augmented but also additional protection stress, yielding true “1 + 1 > 2” effect. To facilitate use vivo, incorporated into thermally responsive hydrogel, which evident anti‐inflammatory properties modulating inflammatory factors significantly promots the wounds. This study underscores value integrated platforms highlights potential versatile CDs promising therapeutic agents biomedical applications.

Language: Английский

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Self‐Cascade of ROS/Glucose‐Scavenging Immunomodulatory Hydrogels for Programmed Therapeutics of Infected Diabetic Ulcers via Nrf2/NF‐κB Pathway

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Diabetic ulcers (DUs) are characterized by a microenvironment with high oxidative stress, blood glucose levels, and recalcitrant bacterial infections. This is accompanied long‐term suppression of endogenous antioxidant systems, which makes their clinical management extremely challenging. To address this issue, hybridized novel gold‐palladium (AuPd) nanoshell the injectable/injectable hydrogel system UiO/AuPd shells /BNN6/PEG@Gel (UAPsBP@Gel) developed. The capable acting as nitric oxide (NO) reactor utilizing synergistic therapy that harnesses NIR‐II light‐triggered photothermal effects controlled release NO gas for treatment to eradicate biofilm infections at different depths. AuPd nanoshells exhibits superoxide dismutase (SOD)‐, oxidase (GOx)‐, catalase (CAT)‐like activities, enabling self‐cascade process scavenging both reactive oxygen species (ROS) glucose. activity reshapes DUs microenvironment, switches on Nrf2/HO‐1 pathway inhibits NF‐κB pathway, promotes macrophage polarization toward anti‐inflammatory M2 phenotype, reduces resulting in efficient immunomodulation. In vitro / vivo results demonstrate UAPsBP@Gel can multifacetedly enhance epithelial rejuvenation through wound hemostasis, pro‐cellular migration vascularization. These highlight programmed therapeutic based UBAPsP@Gel tailored stages infected meet complex needs.

Language: Английский

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Programmed Transformation of Osteogenesis Microenvironment by a Multifunctional Hydrogel to Enhance Repair of Infectious Bone Defects

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Repair of infectious bone defects remains a serious problem in clinical practice owing to the high risk infection and excessive reactive oxygen species (ROS) during early stage, residual bacteria delayed Osseo integrated interface later which jointly creates complex dynamic microenvironment leads non‐union. The melatonin carbon dots (MCDs) possess antibacterial osteogenesis abilities, greatly simplifying composition multifunctional material. Therefore, hydrogel containing MCDs (GH‐MCD) is developed meet multi‐stage repair needs injury this study. GH‐MCD can intelligently release responding acidic scavenge intracellular ROS exhibit good activity by inducing production inhibiting expression secA2 . Moreover, it has long‐lasting antimicrobial repair. RNA‐seq results reveal that hydrogels promote infected healing enhancing cellular resistance bacteria, balancing osteoclastogenesis, regulating immune microenvironment. In conclusion, through programmed transformation microenvironment, providing novel strategy for defects.

Language: Английский

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Melatonin protects against cadmium-induced endoplasmic reticulum stress and ferroptosis through activating Nrf2/HO-1 signaling pathway in mice lung

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115324 - 115324

Published: Feb. 1, 2025

Language: Английский

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Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)

Published: July 22, 2024

Reactive oxygen species (ROS), as metabolic byproducts, play pivotal role in physiological and pathological processes. Recently, studies on the regulation of ROS levels for disease treatments have attracted extensive attention, mainly involving ROS-induced toxicity therapy mediated by producers antioxidant scavengers. Nanotechnology advancements led to development numerous nanomaterials with ROS-modulating capabilities, among which carbon dots (CDs) standing out noteworthy nanomedicines own their distinctive physicochemical properties, high stability, excellent biocompatibility. Despite progress treating ROS-related diseases based CDs, critical issues such rational design principles remain underexplored. The primary cause these may stem from intricate amalgamation core structure, defects, surface states, inherent poses challenges establishing a consistent generalization. This review succinctly summarizes recently ROS-modulated approaches using CDs treatment. Specifically, it investigates established therapeutic strategies CDs-regulated ROS, emphasizing interplay between intrinsic structure generation or scavenging ability. conclusion raises several unresolved key scientific prominent technological bottlenecks, explores future perspectives comprehensive CDs-based therapy.

Language: Английский

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Green Fluorescent Carbon Dots with Critically Controlled Surface States: Make Silk Shine via Feeding Silkworms

Nano Letters, Journal Year: 2024, Volume and Issue: 24(31), P. 9675 - 9682

Published: July 26, 2024

Feeding silkworms with functional materials as additives to produce naturally modified silk is a facile, diverse, controllable, and environmentally friendly method low cost of time investment. Among various additives, carbon dots (CDs) show unique advantages due their excellent biocompatibility fluorescence stability. Here, new type green fluorescent (G-CDs) synthesized high oil–water partition ratio 147, isoelectric point 5.16, an absolute quantum yield 71%, critically controlled surface states. After feeding G-CDs, the weave light yellow cocoons whose visible naked eye under UV light. The luminous sewn onto cloth create striking patterns beautiful fluorescence. Such G-CDs have no adverse effect on survival rate life cycle enable whole bodies glow Based strong fluorescence, chemical stability, biological safety, are found in digestive tracts, glands, feces, cocoons, even moth bodies. accumulate posterior glands where fibroin protein secreted, indicating its stronger combination than sericin, which meets requirements for practical applications.

Language: Английский

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Construction of a Microenvironment‐Responsive Antibacterial Hydrogel Packed With Immunomodulatory Carbonized Polymer Dots for Periodontitis Treatment From Multiple Perspectives

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Periodontitis is an increasingly prevalent oral inflammatory disease, whose treatment faces potent challenges because of recurrent bacterial infections, excessive reactive oxygen species (ROS) production, as well unrelenting inflammation‐induced alveolar bone resorption during the pathological process. Herein, we present rational design and construction a multifunctional hydrogel platform composed quaternized chitosan/oxidized dextran (QCS/OD) component with high bactericidal activity immunomodulatory carbonized polymer dots from resveratrol (RSV‐CPDs) for periodontitis treatment. Such RSV‐CPDs@QCS/OD (RCQD) hydrogels exhibit characteristics including shape adaptability, self‐healing properties, pH‐responsibility, enabling it to adapt irregularly shaped periodontal tissues, degrade gradually in mildly acidic microenvironment periodontitis, release RSV‐CPDs controlled manner. Significantly, RCQD can effectively suppress proliferation bacteria alleviate oxidative stress, relieve inflammation via activating Nrf2/NF‐κB signaling pathway, ultimately fostering favorable environment regeneration both soft hard tissue. Overall, this study highlights great potential treating by addressing practical needs tissue regeneration.

Language: Английский

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Review of carbonaceous nanoparticles for antibacterial uses in various dental infections

Nanotoxicology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 36

Published: Jan. 30, 2025

The mouth cavity is the second most complex microbial community in human body. It composed of bacteria, viruses, fungi, and protozoa. An imbalance oral microbiota may lead to various conditions, including caries, soft tissue infections, periodontitis, root canal peri-implantitis (PI), pulpitis, candidiasis, denture stomatitis. Additionally, several locally administered antimicrobials have been suggested for dentistry surgical non-surgical applications. main drawbacks are increased antimicrobial resistance, risk upsetting natural microbiota, hypersensitivity responses. Because their unique physiochemical characteristics, nanoparticles (NPs) can circumvent antibiotic-resistance mechanisms exert action via a variety new bactericidal routes. anti-microbial properties, carbon-based NPs becoming more effective antibacterial agents. Periodontitis, PI, dentin other dental diseases among conditions that be treated using carbon (CNPs) like graphene oxide dots. outline scientific development multifunctional CNPs concerning disorders will given before talking about significant influence on health. Some these illnesses include pulp disorders, PI. We also review remaining research application barriers possible future problems.

Language: Английский

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New Advances in Periodontal Functional Materials Based on Antibacterial, Anti‐Inflammatory, and Tissue Regeneration Strategies

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, gaining attention. Current novel biomaterials address key clinical issues like infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, tissue regeneration properties. However, strategies that integrate advantages these to achieve synergistic therapeutic effects by clearing biofilms, inhibiting inflammation activation, restoring periodontal soft hard functions remain very limited. Recent studies highlight link between periodontitis systemic diseases, underscoring complexity disease. There an urgent need find comprehensive treatment plans requirements. Whether integrating new enhance existing treatments or developing approaches replace traditional therapies, efforts will drive advancements in treatment. Therefore, this review compares with treatments. It highlights design concepts mechanisms functional materials, their properties, discusses importance strategies. This aims provide guidance for emerging research promote development precise efficient

Language: Английский

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