Structurally Oriented Carbon Dots as ROS Nanomodulators for Dynamic Chronic Inflammation and Infection Elimination

ACS Nano, Journal Year: 2024, Volume and Issue: 18(33), P. 22055 - 22070

Published: Aug. 8, 2024

The selective elimination of cytotoxic ROS while retaining essential ones is pivotal in the management chronic inflammation. Co-occurring bacterial infection further complicates conditions, necessitating precision and an efficacious treatment strategy. Herein, dynamic nanomodulators are rationally constructed through regulating surface states herbal carbon dots (CDs) for on-demand inflammation or elimination. phenolic OH containing CDs derived from honeysuckle (HOCD) dandelion (DACD) demonstrated appropriate redox potentials, ensuring their ability to scavenge such as ·OH ONOO–, invalidity toward O2·–, H2O2, NO. This enables efficient without affecting signal pathways. C–N/C═N taxus leaves (TACD) DACD renders them with suitable band structures, facilitating absorption red region generation O2·– upon light irradiation sterilization. Specifically, facilely prepared demonstrates fascinating modulating ability, making it highly addressing concurrent infection, diabetic wound infection. regulation strategy facilitates realization precise minimal side effects, holding immense potential clinical practice.

Language: Английский

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Programmed Transformation of Osteogenesis Microenvironment by a Multifunctional Hydrogel to Enhance Repair of Infectious Bone Defects

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

Abstract Repair of infectious bone defects remains a serious problem in clinical practice owing to the high risk infection and excessive reactive oxygen species (ROS) during early stage, residual bacteria delayed Osseo integrated interface later which jointly creates complex dynamic microenvironment leads non‐union. The melatonin carbon dots (MCDs) possess antibacterial osteogenesis abilities, greatly simplifying composition multifunctional material. Therefore, hydrogel containing MCDs (GH‐MCD) is developed meet multi‐stage repair needs injury this study. GH‐MCD can intelligently release responding acidic scavenge intracellular ROS exhibit good activity by inducing production inhibiting expression secA2 . Moreover, it has long‐lasting antimicrobial repair. RNA‐seq results reveal that hydrogels promote infected healing enhancing cellular resistance bacteria, balancing osteoclastogenesis, regulating immune microenvironment. In conclusion, through programmed transformation microenvironment, providing novel strategy for defects.

Language: Английский

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Melatonin protects against cadmium-induced endoplasmic reticulum stress and ferroptosis through activating Nrf2/HO-1 signaling pathway in mice lung

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115324 - 115324

Published: Feb. 1, 2025

Language: Английский

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Carbon Dots with Integrated Photothermal Antibacterial and Heat‐Enhanced Antioxidant Properties for Diabetic Wound Healing

Small, Journal Year: 2024, Volume and Issue: 20(45)

Published: July 25, 2024

Abstract Diabetic wounds pose a persistent challenge due to their slow healing nature, primarily caused by bacterial infection and excessive reactive oxygen species (ROS)‐induced inflammation. In this study, carbon dots with synergistic antibacterial antioxidant properties, referred as AA‐CDs, are developed specifically for diabetic wound using straightforward solvothermal method. By utilizing cost‐effective precursors like citric acid ascorbic acid, AA‐CDs engineered possess tailored functions of photothermal sterilization ROS scavenging. The resulting demonstrats broad‐spectrum activity, particularly against multidrug‐resistant strains, along efficient scavenging both in solution within cells. Additionally, exhibits protective effect oxidative stress‐induced damage. Notably, high conversion efficiency (41.18%), displays heat‐enhanced performance, providing not only augmented but also additional protection stress, yielding true “1 + 1 > 2” effect. To facilitate use vivo, incorporated into thermally responsive hydrogel, which evident anti‐inflammatory properties modulating inflammatory factors significantly promots the wounds. This study underscores value integrated platforms highlights potential versatile CDs promising therapeutic agents biomedical applications.

Language: Английский

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Self‐Cascade of ROS/Glucose‐Scavenging Immunomodulatory Hydrogels for Programmed Therapeutics of Infected Diabetic Ulcers via Nrf2/NF‐κB Pathway

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Diabetic ulcers (DUs) are characterized by a microenvironment with high oxidative stress, blood glucose levels, and recalcitrant bacterial infections. This is accompanied long‐term suppression of endogenous antioxidant systems, which makes their clinical management extremely challenging. To address this issue, hybridized novel gold‐palladium (AuPd) nanoshell the injectable/injectable hydrogel system UiO/AuPd shells /BNN6/PEG@Gel (UAPsBP@Gel) developed. The capable acting as nitric oxide (NO) reactor utilizing synergistic therapy that harnesses NIR‐II light‐triggered photothermal effects controlled release NO gas for treatment to eradicate biofilm infections at different depths. AuPd nanoshells exhibits superoxide dismutase (SOD)‐, oxidase (GOx)‐, catalase (CAT)‐like activities, enabling self‐cascade process scavenging both reactive oxygen species (ROS) glucose. activity reshapes DUs microenvironment, switches on Nrf2/HO‐1 pathway inhibits NF‐κB pathway, promotes macrophage polarization toward anti‐inflammatory M2 phenotype, reduces resulting in efficient immunomodulation. In vitro / vivo results demonstrate UAPsBP@Gel can multifacetedly enhance epithelial rejuvenation through wound hemostasis, pro‐cellular migration vascularization. These highlight programmed therapeutic based UBAPsP@Gel tailored stages infected meet complex needs.

Language: Английский

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New Advances in Periodontal Functional Materials Based on Antibacterial, Anti‐Inflammatory, and Tissue Regeneration Strategies

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, gaining attention. Current novel biomaterials address key clinical issues like infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, tissue regeneration properties. However, strategies that integrate advantages these to achieve synergistic therapeutic effects by clearing biofilms, inhibiting inflammation activation, restoring periodontal soft hard functions remain very limited. Recent studies highlight link between periodontitis systemic diseases, underscoring complexity disease. There an urgent need find comprehensive treatment plans requirements. Whether integrating new enhance existing treatments or developing approaches replace traditional therapies, efforts will drive advancements in treatment. Therefore, this review compares with treatments. It highlights design concepts mechanisms functional materials, their properties, discusses importance strategies. This aims provide guidance for emerging research promote development precise efficient

Language: Английский

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Near‐infrared Emission Carbon Dots Derived from Bromo‐Substituted Perylene Derivatives with Simultaneously High Type I/II ROS Generation for Effective Bacterial Elimination and Tumor Ablation

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Abstract Bacterial infections and tumor tissues are characterized by complex microenvironments with uneven oxygen availability. Effective photodynamic therapy for these conditions requires photosensitizers that can perform optimally within such environments, specifically generating both type I II reactive species (ROS) simultaneously. Carbon dots (CDs), a of fluorescent nanomaterial smaller than 10 nm, commonly used to treat bacterial tumors. However, their current limitations, as short maximum absorption emission wavelengths, significantly restrict therapeutic efficacy in deep tissues. In response challenges, new carbon near‐infrared (NIR) properties is reported, featuring peak beyond 700 nm (NIR‐I region). These CDs offer strong tissue penetration reduced advantages. Additionally, bromine atom doping enhances the generation ROS through efficient processes. vitro studies demonstrated high antibacterial antitumor applications. Ultimately, findings translate into significant effectiveness treating skin tumors vivo. This study employs bromine‐doped nanomaterials, which demonstrate fluorescence NIR region, achieve treatment ablation microenvironments.

Language: Английский

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Carbon Dots in the Pathological Microenvironment: ROS Producers or Scavengers?

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(29)

Published: July 22, 2024

Reactive oxygen species (ROS), as metabolic byproducts, play pivotal role in physiological and pathological processes. Recently, studies on the regulation of ROS levels for disease treatments have attracted extensive attention, mainly involving ROS-induced toxicity therapy mediated by producers antioxidant scavengers. Nanotechnology advancements led to development numerous nanomaterials with ROS-modulating capabilities, among which carbon dots (CDs) standing out noteworthy nanomedicines own their distinctive physicochemical properties, high stability, excellent biocompatibility. Despite progress treating ROS-related diseases based CDs, critical issues such rational design principles remain underexplored. The primary cause these may stem from intricate amalgamation core structure, defects, surface states, inherent poses challenges establishing a consistent generalization. This review succinctly summarizes recently ROS-modulated approaches using CDs treatment. Specifically, it investigates established therapeutic strategies CDs-regulated ROS, emphasizing interplay between intrinsic structure generation or scavenging ability. conclusion raises several unresolved key scientific prominent technological bottlenecks, explores future perspectives comprehensive CDs-based therapy.

Language: Английский

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Green Fluorescent Carbon Dots with Critically Controlled Surface States: Make Silk Shine via Feeding Silkworms

Nano Letters, Journal Year: 2024, Volume and Issue: 24(31), P. 9675 - 9682

Published: July 26, 2024

Feeding silkworms with functional materials as additives to produce naturally modified silk is a facile, diverse, controllable, and environmentally friendly method low cost of time investment. Among various additives, carbon dots (CDs) show unique advantages due their excellent biocompatibility fluorescence stability. Here, new type green fluorescent (G-CDs) synthesized high oil–water partition ratio 147, isoelectric point 5.16, an absolute quantum yield 71%, critically controlled surface states. After feeding G-CDs, the weave light yellow cocoons whose visible naked eye under UV light. The luminous sewn onto cloth create striking patterns beautiful fluorescence. Such G-CDs have no adverse effect on survival rate life cycle enable whole bodies glow Based strong fluorescence, chemical stability, biological safety, are found in digestive tracts, glands, feces, cocoons, even moth bodies. accumulate posterior glands where fibroin protein secreted, indicating its stronger combination than sericin, which meets requirements for practical applications.

Language: Английский

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Melatonin mediates intestinal barrier dysfunction and systemic inflammation in moderate-severe OSA patients

Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)

Published: July 8, 2024

Intestinal barrier dysfunction and systemic inflammation are common in obstructive sleep apnoea (OSA). We aimed to investigate the role of melatonin, an anti-inflammatory mediator, mediating relationships between OSA, intestinal inflammation.

Language: Английский

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