ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 4254 - 4269
Published: June 12, 2024
The
skin,
being
the
largest
organ
of
human
body,
is
susceptible
to
damage
resulting
in
wounds
that
are
vulnerable
pathogenic
attacks
and
fail
provide
effective
protection
for
internal
tissues.
Therefore,
it
crucial
expedite
wound
healing.
In
recent
years,
microneedles
have
garnered
significant
attention
as
an
innovative
drug
delivery
system
owing
their
noninvasive
painless
administration,
simplified
application
process,
precise
control
over
release,
versatile
loading
capabilities.
Consequently,
they
hold
immense
potential
treatment
skin
wound.
This
review
presents
a
comprehensive
design
strategy
microneedle
promoting
First,
process
healing
characteristics
specific
elucidated.
strategies
subsequently
presented
classified
based
on
structural
therapeutic
methodologies.
Finally,
succinct
recapitulation
previously
discussed
points
prospective
analysis
provided.
International Journal of Nanomedicine,
Journal Year:
2022,
Volume and Issue:
Volume 17, P. 2735 - 2750
Published: June 1, 2022
Bacterial
biofilm-related
wound
infections
threaten
human
health
due
to
the
lack
of
efficient
treatments.
Therefore,
developing
a
novel
strategy
for
infection
care
is
urgently
needed.Cube-shaped
Cu2WS4
nanocrystals
(CWSNs)
were
successfully
prepared
via
microwave-assisted
method.
CWSNs,
as
photocatalysts,
first
studied
by
using
fluorescence
spectroscopy
their
ability
generate
reactive
oxygen
species
(ROS).
The
antibacterial
and
biofilm
inhibition
abilities
CWSNs
determined
in
vitro
Staphylococcus
aureus
(S.aureus)
model
bacterium.
Moreover,
CWSN
gel
was
applied
treat
S.
aureus-infected
wounds
mice.
toxicity
evaluated
through
cell
vivo
animal
experiments.Studies
on
properties
demonstrated
that
these
nanomaterials
can
catalyze
generation
hydroxyl
radicals
(•OH)
without
addition
H2O2
after
visible-light
irradiation,
indicating
photocatalytic
ability.
experimental
results
showed
not
only
adhered
surfaces
kill
bacteria,
but
also
inhibited
formation.
study
produced
excellent
effects
against
infected
mice
effectively
promoted
healing.
Furthermore,
tests
have
negligible
vivo.This
work
provides
potential
nanoagent
bacterial
killing,
biofilms
growth
treatment.
Advanced NanoBiomed Research,
Journal Year:
2022,
Volume and Issue:
3(2)
Published: Dec. 30, 2022
Benefiting
from
the
advantages
of
minimal
invasiveness,
painlessness,
and
ease
to
use,
microneedle
patches
(MPs)
have
been
extensively
studied
in
biomedical
field
through
a
physical
penetration
enhancement
pathway.
This
study
systematically
summarizes
preparation
methods,
function
optimization,
diagnostic
therapeutic
applications
MPs.
First
all,
raw
materials
methods
commonly
used
different
processes
for
MPs
are
highlighted.
Then,
corresponding
solutions
problems
facing
MPs,
such
as
poor
tissue
adhesion,
weak
mechanical
strength,
low
drug
delivery
utilization
their
development
application,
emphasized,
which
serve
approaches
improve
performance
Subsequently,
latest
wound
healing
health
monitoring
recent
years
summarized
in‐depth,
revealing
unique
merits
diagnosis
treatment.
Finally,
key
points
urgent
improvement
clinical
translation
commercial
application
deliberated,
order
inspire
future
direction
multifunctional
intelligent
ACS Applied Bio Materials,
Journal Year:
2024,
Volume and Issue:
7(7), P. 4254 - 4269
Published: June 12, 2024
The
skin,
being
the
largest
organ
of
human
body,
is
susceptible
to
damage
resulting
in
wounds
that
are
vulnerable
pathogenic
attacks
and
fail
provide
effective
protection
for
internal
tissues.
Therefore,
it
crucial
expedite
wound
healing.
In
recent
years,
microneedles
have
garnered
significant
attention
as
an
innovative
drug
delivery
system
owing
their
noninvasive
painless
administration,
simplified
application
process,
precise
control
over
release,
versatile
loading
capabilities.
Consequently,
they
hold
immense
potential
treatment
skin
wound.
This
review
presents
a
comprehensive
design
strategy
microneedle
promoting
First,
process
healing
characteristics
specific
elucidated.
strategies
subsequently
presented
classified
based
on
structural
therapeutic
methodologies.
Finally,
succinct
recapitulation
previously
discussed
points
prospective
analysis
provided.
