Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(31)
Published: April 14, 2024
Although
nanozymes
have
drawn
great
attention
over
the
past
decade,
activities
of
peroxidase-like,
oxidase-like,
and
catalase-like
are
often
pH
dependent
with
elusive
mechanism,
which
largely
restricts
their
application.
Therefore,
a
systematical
discussion
on
pH-related
catalytic
mechanisms
together
methods
to
overcome
this
limitation
is
in
need.
In
review,
various
exhibiting
pH-dependent
collected
root
causes
for
dependence
comprehensively
analyzed.
Subsequently,
regulatory
concepts
including
environment
reconstruction
direct
activity
improvement
break
restriction
summarized.
Moreover,
applications
pH-independent
sensing,
disease
therapy,
pollutant
degradation
overviewed.
Finally,
current
challenges
future
opportunities
development
suggested.
It
anticipated
that
review
will
promote
further
design
broaden
application
range
higher
efficiency.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(5), P. 1813 - 1824
Published: Jan. 25, 2024
Single-atom
nanozymes
(SAzymes)
have
been
greatly
developed
for
rapid
detection,
owing
to
their
rich
active
sites
and
excellent
catalytic
activity.
Although
several
reviews
concentrating
on
SAzymes
reported,
they
mainly
focused
advanced
synthesis,
sensing
mechanisms,
biomedical
applications.
To
date,
few
elaborate
the
promising
applications
of
in
food
safety
inspection
nutrition
evaluation.
In
this
paper,
we
systematically
reviewed
enzyme-like
activity
mechanism,
addition
recent
research
advances
domain
evaluation
past
years.
Furthermore,
current
challenges
hampering
practical
assay
are
summarized
analyzed,
possible
areas
focusing
SAzyme-based
sensors
testing
also
proposed.
TrAC Trends in Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
172, P. 117573 - 117573
Published: Feb. 9, 2024
Nanozymes,
enzyme-mimetic
nanomaterials
that
combine
features
of
nanoscale
material
with
the
catalytic
properties
enzymes,
have
undergone
rapid
development
in
recent
years.
While
enzymes
remained
integral
to
biosensor
technologies
for
past
few
decades,
potential
nanozymes
overcome
low
stability
and
high
production
costs
biological
is
turning
them
into
promising
candidates.
Over
decade,
been
explored
a
myriad
biosensing
applications.
However,
only
small
subset
these
efforts
has
resulted
devices
platforms
are
potentially
suitable
on-site/point-of-care
monitoring.
To
promote
this
area,
review
first
provides
concise
overview
different
paper-based
technologies,
their
architecture
functionality,
language
conducive
nanozyme
research
community.
The
review,
then,
critically
discusses
progress
made
integration
on-site
detection
food
contaminants,
environmental
pollutants,
disease
biomarkers.
challenges
associated
transition
solution-based
biosensors
relevant
highlighted,
strategies
those
proposed.
We
envision
could
narrow
gap
impeding
translation
nanozyme-based
from
laboratories
real-world
scenarios
by
encouraging
consolidated
cross-disciplinary
trans-sectoral
efforts.
Journal of Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: May 6, 2024
Abstract
Nanozyme,
characterized
by
outstanding
and
inherent
enzyme-mimicking
properties,
have
emerged
as
highly
promising
alternatives
to
natural
enzymes
owning
their
exceptional
attributes
such
regulation
of
oxidative
stress,
convenient
storage,
adjustable
catalytic
activities,
remarkable
stability,
effortless
scalability
for
large-scale
production.
Given
the
potent
regulatory
function
nanozymes
on
stress
coupled
with
fact
that
reactive
oxygen
species
(ROS)
play
a
vital
role
in
occurrence
exacerbation
metabolic
diseases,
nanozyme
offer
unique
perspective
therapy
through
multifunctional
achieving
essential
results
treatment
diseases
directly
scavenging
excess
ROS
or
regulating
pathologically
related
molecules.
The
rational
design
strategies,
nanozyme-enabled
therapeutic
mechanisms
at
cellular
level,
therapies
several
typical
underlying
are
discussed,
mainly
including
obesity,
diabetes,
cardiovascular
disease,
diabetic
wound
healing,
others.
Finally,
pharmacokinetics,
safety
analysis,
challenges,
outlooks
application
also
presented.
This
review
will
provide
some
instructive
perspectives
promote
development
strategies
disease
therapy.
Graphical
Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 142751 - 142751
Published: Jan. 1, 2025
Inorganic
nanozymes
hold
promise
for
biomolecule
sensing
but
face
challenges
like
complex
fabrication,
toxicity,
and
low
sustainability,
limiting
their
use.
To
overcome
these,
a
sustainable
organic
nanozyme
(OA
nanozyme)
was
created
using
amino
acids
biocompatible
polymer
effective
histamine
detection.
The
OA
exhibits
peroxidase-like
activity
fabricated
through
single
chelation/polymer
entanglement
method,
enabling
rapid
production
(within
3
h)
with
uniform
morphology
(≤100
nm
diameter)
negative
surface
charge
at
neutral
pH.
It
shows
decent
kinetic
performance
(Km
=
0.009
mM
H
Chemical Society Reviews,
Journal Year:
2023,
Volume and Issue:
52(15), P. 5088 - 5134
Published: Jan. 1, 2023
Sensors,
the
underlying
technology
that
supports
Internet
of
Things,
are
undergoing
multi-disciplinary
integration
development
to
constantly
improve
efficiency
human
production
and
life.
Simultaneously,
application
scenarios
in
emerging
fields
such
as
medical
diagnosis,
environmental
monitoring
industrial
safety
put
forward
higher
requirements
for
sensing
capabilities.
Over
last
decade,
single-atom
catalysts
(SACs)
have
attracted
tremendous
attention
environment
energy
due
their
high
atom
utilization
efficiencies,
controllable
active
sites,
tailorable
coordination
environments
structural/chemical
stability.
These
extraordinary
characteristics
extend
sensitivity
selectivity
sensors
beyond
current
limitations.
Here,
we
start
with
working
principles
SAC-based
sensors,
summarize
relationship
between
sensor
performance
intrinsic
properties
SACs,
followed
by
an
overview
design
strategy
development.
We
then
review
recent
advances
different
highlight
future
opportunities
challenges
exciting
applications.
