The
complex
microenvironment
of
persistent
inflammation
and
bacterial
infection
is
a
major
challenge
in
chronic
diabetic
wounds.
development
nanozymes
capable
efficiently
scavenging
reactive
oxygen
species
(ROS)
promising
method
to
promote
wound
healing.
However,
many
show
rather
limited
antioxidant
activity
ROS-dependent
antibacterial
effects
under
certain
circumstances,
further
weakening
their
ability
scavenge
ROS.
To
meet
these
challenges,
electronically
regulated
bioheterojunction
(E-bio-HJ)
nanozyme
hydrogels
derived
from
metal-organic
frameworks
(MOFs)
were
designed
prepared
via
an
interface
engineering
strategy.
Owing
the
electron
transfer
redistribution
abundant
highly
dispersed
Cu-O-Zn
sites
at
heterogeneous
interface,
E-bio-HJ
exhibited
catalase
(CAT)-like
with
ultrahigh
hydrogen
peroxide
affinity
(
ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(35), P. 24327 - 24349
Published: Aug. 22, 2024
A
series
of
progress
has
been
made
in
the
field
antimicrobial
use
nanozymes
due
to
their
superior
stability
and
decreased
susceptibility
drug
resistance.
However,
catalytically
generated
reactive
oxygen
species
(ROS)
are
insufficient
for
coping
with
multidrug-resistant
organisms
(MDROs)
complex
wound
environments
low
targeting
ability
catalytic
activity.
To
address
this
problem,
chemically
stable
copper-gallic
acid-vancomycin
(CuGA-VAN)
nanoneedles
were
successfully
constructed
by
a
simple
approach
bacteria;
these
exhibit
OXD-like
GSH-px-like
dual
enzyme
activities
produce
ROS
induce
bacterial
cuproptosis-like
death,
thereby
eliminating
MDRO
infections.
The
results
Gels,
Journal Year:
2024,
Volume and Issue:
10(4), P. 241 - 241
Published: April 1, 2024
This
manuscript
explores
self-healing
hydrogels
as
innovative
solutions
for
diverse
wound
management
challenges.
Addressing
antibiotic
resistance
and
tailored
care,
these
exhibit
promising
outcomes,
including
accelerated
closure
tissue
regeneration.
Advancements
in
multifunctional
with
controlled
drug
release,
antimicrobial
properties,
real-time
assessment
capabilities
signal
a
significant
leap
toward
patient-centered
treatments.
However,
challenges
such
scalability,
long-term
safety
evaluation,
variability
clinical
outcomes
persist.
Future
directions
emphasize
personalized
medicine,
manufacturing
innovation,
rigorous
evaluation
through
trials,
interdisciplinary
collaboration.
features
the
ongoing
pursuit
of
effective,
adaptable,
comprehensive
care
to
transform
medical
treatments
improve
patient
outcomes.
Journal of Tissue Engineering,
Journal Year:
2024,
Volume and Issue:
15
Published: Jan. 1, 2024
The
rising
prevalence
of
diabetes
has
underscored
concerns
surrounding
diabetic
wounds
and
their
potential
to
induce
disability.
intricate
healing
mechanisms
are
multifaceted,
influenced
by
ambient
microenvironment,
including
prolonged
hyperglycemia,
severe
infection,
inflammation,
elevated
levels
reactive
oxygen
species
(ROS),
ischemia,
impaired
vascularization,
altered
wound
physicochemical
properties.
In
recent
years,
hydrogels
have
emerged
as
promising
candidates
for
treatment
owing
exceptional
biocompatibility
resemblance
the
extracellular
matrix
(ECM)
through
a
three-dimensional
(3D)
porous
network.
This
review
will
first
summarize
microenvironment
alterations
occurring
in
wounds,
aiming
provide
comprehensive
understanding
its
pathogenesis,
then
classification
recently
developed
be
presented,
encompassing
properties
such
hypoglycemic
effects,
anti-inflammatory
capabilities,
antibacterial
attributes,
ROS
scavenging
abilities,
promotion
angiogenesis,
pH
responsiveness,
more.
primary
objective
is
offer
valuable
reference
repairing
based
on
unique
microenvironment.
Moreover,
this
paper
outlines
avenues
future
advancements
hydrogel
dressings
facilitate
expedite
process
wounds.
Biomedical Materials,
Journal Year:
2024,
Volume and Issue:
19(4), P. 042008 - 042008
Published: May 20, 2024
Gelatin
methacryloyl
(GelMA)
hydrogels
have
gained
significant
recognition
as
versatile
biomaterials
in
the
biomedical
domain.
GelMA
emulate
vital
characteristics
of
innate
extracellular
matrix
by
integrating
cell-adhering
and
metalloproteinase-responsive
peptide
motifs.
These
features
enable
cellular
proliferation
spreading
within
GelMA-based
hydrogel
scaffolds.
Moreover,
displays
flexibility
processing,
it
experiences
crosslinking
when
exposed
to
light
irradiation,
supporting
development
with
adjustable
mechanical
characteristics.
The
drug
delivery
landscape
has
been
reshaped
hydrogels,
offering
a
favorable
platform
for
controlled
sustained
release
therapeutic
actives.
tunable
physicochemical
precise
modulation
kinetics
release,
ensuring
optimal
effectiveness.
In
tissue
engineering,
perform
an
essential
role
design
scaffold,
providing
biomimetic
environment
conducive
cell
adhesion,
proliferation,
differentiation.
Incorporating
three-dimensional
printing
further
improves
its
applicability
developing
complicated
constructs
spatial
precision.
Wound
healing
applications
showcase
bioactive
dressings,
fostering
microenvironment
regeneration.
inherent
biocompatibility
provide
efficiency
closure
wounds
repair.
stand
at
forefront
innovation,
addressing
diverse
challenges
delivery,
wound
healing.
This
review
provides
comprehensive
overview,
in-depth
understanding
hydrogel's
potential
impact
on
progressing
sciences.
Materials Horizons,
Journal Year:
2024,
Volume and Issue:
11(18), P. 4275 - 4310
Published: Jan. 1, 2024
This
comprehensive
review
systematically
summarizes
the
intrinsic
mechanism
of
different
metal
ion
(such
as
Fe
3+
/Fe
2+
,
Cu
/Cu
+
Ca
Zn
Mn
Na
/K
and
Mg
)-mediated
interference
therapies
their
research
progress
in
cancer
treatment.
