The
complex
microenvironment
of
persistent
inflammation
and
bacterial
infection
is
a
major
challenge
in
chronic
diabetic
wounds.
development
nanozymes
capable
efficiently
scavenging
reactive
oxygen
species
(ROS)
promising
method
to
promote
wound
healing.
However,
many
show
rather
limited
antioxidant
activity
ROS-dependent
antibacterial
effects
under
certain
circumstances,
further
weakening
their
ability
scavenge
ROS.
To
meet
these
challenges,
electronically
regulated
bioheterojunction
(E-bio-HJ)
nanozyme
hydrogels
derived
from
metal-organic
frameworks
(MOFs)
were
designed
prepared
via
an
interface
engineering
strategy.
Owing
the
electron
transfer
redistribution
abundant
highly
dispersed
Cu-O-Zn
sites
at
heterogeneous
interface,
E-bio-HJ
exhibited
catalase
(CAT)-like
with
ultrahigh
hydrogen
peroxide
affinity
(
Polymers,
Journal Year:
2024,
Volume and Issue:
16(19), P. 2818 - 2818
Published: Oct. 5, 2024
Hydrogels
have
emerged
as
promising
candidates
for
biomedical
applications,
especially
in
the
treatment
of
skin
wounds,
a
result
their
unique
structural
properties,
highly
tunable
physicochemical
and
excellent
biocompatibility.
The
integration
smart-response
features
into
hydrogels
allows
dynamic
responses
to
different
external
or
internal
stimuli.
Therefore,
this
paper
reviews
design
smart-responsive
microenvironments
field
wound
therapy.
First,
three
typical
chronic
difficult-to-heal
wounds
key
mechanisms
affecting
healing
therapeutic
measures
are
outlined.
Strategies
construction
stimulus-responsive
(e.g.,
pH,
ROS,
enzymes,
glucose)
temperature,
light,
electricity,
magnetic
fields)
highlighted
from
perspective
microenvironment
vitro
environment,
constitutive
relationships
between
material
design,
intelligent
response,
revealed.
Finally,
discusses
severe
challenges
faced
by
during
repair
provides
an
outlook
on
combination
artificial
intelligence
give
scientific
direction
creating
using
hydrogel
dressings
that
respond
stimuli
clinic.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 28, 2024
Periodontal
disease
is
a
multifactorial,
bacterially
induced
inflammatory
disorder
characterized
by
progressive
destruction
of
periodontal
tissues.
Additionally,
diabetes
mellitus
exacerbates
periodontitis,
resulting
in
expedited
resorption
bone.
However,
methods
such
as
mechanical
debridement,
anti-inflammatory
medications,
and
surgical
approaches
often
fail
to
eradicate
local
infections
inflammation,
complicating
the
reconstruction
tissue
structures.
Consequently,
there
an
urgent
need
devise
novel
strategy
for
managing
diabetic
conditions.
Here,
multifunctional
controlled-release
drug
delivery
system
(GOE1)
developed
encapsulating
self-assembled
nanoparticles
(consisting
chlorhexidine
acetate
epigallocatechin-3-gallate)
into
hydrogel
matrix
composed
gelatin
methacryloyl
oxidized
hyaluronic
acid.
In
vitro
experiments
demonstrate
that
GOE1
possesses
good
antimicrobial,
antioxidant
properties,
transgenic
sequence
genomics
further
illustrates
IL-17-producing
RAW
264.7
macrophages
are
critical
mediating
M1/M2
macrophage
transition
provide
favorable
immune
microenvironment.
addition,
vivo
reveal
significantly
ameliorates
inflammation
reduces
loss
alveolar
bone
reducing
infiltration
collagen
destruction.
Overall,
offers
promising
therapeutic
option
periodontitis.
Inorganic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 4, 2025
The
strong
metal-support
interaction
(SMSI)
in
supported
metal
catalysts
represents
a
crucial
factor
the
design
of
highly
efficient
heterogeneous
catalysts.
This
can
modify
surface
adsorption
state,
electronic
structure,
and
coordination
environment
metal,
altering
interface
structure
catalyst.
These
changes
serve
to
enhance
catalyst's
activity,
stability,
reaction
selectivity.
In
recent
years,
multitude
researchers
have
uncovered
range
novel
SMSI
types
induction
methods
including
oxidized
(O-SMSI),
adsorbent-mediated
(A-SMSI),
wet
chemically
induced
(Wc-SMSI).
Consequently,
systematic
critical
review
is
desirable
illuminate
latest
advancements
deliberate
its
application
within
article
provides
characteristics
various
most
methods.
It
concluded
that
significantly
contributes
enhancing
catalyst
selectivity,
increasing
catalytic
activity.
Furthermore,
this
paper
offers
comprehensive
extensive
electrocatalysis
hydrogen
evolution
(HER),
oxygen
(OER),
reduction
(ORR),
carbon
dioxide
(CO2RR).
Finally,
opportunities
challenges
faces
future
are
discussed.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 28, 2025
Abstract
Light‐driven
conversion
of
CO
2
to
fuel
is
the
most
attractive
approach
achieve
global
carbon
neutrality.
However,
severe
recombination
photogenerated
carriers
and
narrow
range
solar
spectrum
utilization
make
its
application
still
challenging.
Here,
a
metal‐phenolic
networks
(MPNs)
coated
layered
double
hydroxide
S‐scheme
photothermal
nanoreactor
(CoAl‐LDH
@
TA‐Cu‐6
nm)
designed.
It
can
efficiently
capture
infrared
light
surprising
23‐fold
performance
improvement
over
CoAl‐LDH
under
simulated
sunlight
illumination.
A
variety
in
situ
characterizations
(in
XPS
DRIFTS)
DFT
calculations
explore
that
fascinating
comes
from
efficient
charge
separation
migration
catalysts,
properties
endowed
by
creatively
introduced
MPNs
nanoscale
pseudo‐greenhouse
effect
brought
about
ingenious
coating
structure.
This
work
provides
new
insights
into
integration
micromorphology
electronic
state
modification
(defect
heterojunction
engineering)
broad
spectrally
responsive
photocatalytic
design
reveals
mechanism
for
synergistically
enhancing
activity
at
nano‐,
atomic‐,
subatomic‐scales,
giving
golden
key
address
energy
crisis
environmental
challenges.
Polyphenols,
which
are
compounds
characterized
by
the
presence
of
phenolic
hydroxyl
groups,
abundantly
found
in
natural
plants
and
exist
highly
complex
forms
within
living
organisms.
As
some
most
prevalent
nature,
polyphenols
possess
significant
medicinal
value
due
to
their
unique
structural
features,
particularly
therapeutic
efficacy
antitumor,
anti-inflammatory,
antibacterial
applications.
In
context
inflammation
therapy,
polyphenolic
can
inhibit
excessive
release
inflammatory
mediators
from
cells,
thereby
mitigating
inflammation.
Furthermore,
these
exhibit
strong
antioxidant
properties,
enabling
them
scavenge
free
radicals
reactive
oxygen
species
(ROS),
reduce
oxidative
stress-related
damage,
exert
anti-inflammatory
effects.
Due
multiple
groups
ability
chelate
various
metals,
extensively
utilized
synthesis
self-assembled
nanoparticles
for
treatment
diseases.
Numerous
studies
have
demonstrated
that
profile
formed
through
self-assembly
with
metal
ions
surpasses
alone.
This
Review
will
focus
on
different
generate
nanoparticles,
characterization,
applications
inflammation-related
diseases,
providing
researchers
new
insights
into
synthetic
study
metal-polyphenol
nanocomposites
biological
