Bioactive Materials,
Journal Year:
2016,
Volume and Issue:
1(1), P. 39 - 55
Published: May 12, 2016
The
encapsulation
of
stem
cells
in
a
hydrogel
substrate
provides
promising
future
biomedical
applications.
However,
communications
between
hydrogels
and
is
complicated;
various
factors
such
as
porosity,
different
polymer
types,
stiffness,
compatibility
degradation
will
lead
to
cell
survival
or
death.
Hydrogels
mimic
the
three-dimensional
extracellular
matrix
provide
friendly
environment
for
cells.
On
other
hand,
can
sense
surroundings
make
next
progression,
stretching
out,
proliferating
just
remain.
As
such,
understanding
correlation
crucial.
In
this
Review,
we
first
discuss
varying
types
cells,
which
are
most
commonly
used
fields
further
investigate
how
interact
with
from
perspective
their
application,
while
providing
insights
into
design
development
drug
delivery,
tissue
engineering
regenerative
medicine
purpose.
addition,
compare
results
time
pore
size
well
peptide
respected
journals.
We
also
discussed
recently
magnificent
materials
effects
regulate
fate.
International Journal of Molecular Sciences,
Journal Year:
2015,
Volume and Issue:
16(8), P. 18149 - 18184
Published: Aug. 5, 2015
Cell
adhesion
is
essential
in
cell
communication
and
regulation,
of
fundamental
importance
the
development
maintenance
tissues.
The
mechanical
interactions
between
a
its
extracellular
matrix
(ECM)
can
influence
control
behavior
function.
function
has
created
tremendous
interests
developing
methods
for
measuring
studying
properties.
study
could
be
categorized
into
attachment
detachment
events.
been
widely
explored
via
both
events
many
important
purposes
cellular
biology,
biomedical,
engineering
fields.
further
grouped
population
single
approach.
Various
techniques
to
measure
have
applied
fields
order
gain
understanding
signaling
pathways,
biomaterial
studies
implantable
sensors,
artificial
bone
tooth
replacement,
tissue-on-a-chip
organ-on-a-chip
tissue
engineering,
effects
biochemical
treatments
environmental
stimuli
adhesion,
potential
drug
treatments,
cancer
metastasis
study,
determination
properties
normal
cancerous
cells.
This
review
discussed
overview
available
through
Chemical Reviews,
Journal Year:
2017,
Volume and Issue:
117(20), P. 12764 - 12850
Published: Oct. 9, 2017
The
cell
microenvironment
has
emerged
as
a
key
determinant
of
behavior
and
function
in
development,
physiology,
pathophysiology.
extracellular
matrix
(ECM)
within
the
serves
not
only
structural
foundation
for
cells
but
also
source
three-dimensional
(3D)
biochemical
biophysical
cues
that
trigger
regulate
behaviors.
Increasing
evidence
suggests
3D
character
is
required
development
many
critical
responses
observed
vivo,
fueling
surge
functional
biomimetic
materials
engineering
microenvironment.
Progress
design
such
improved
control
behaviors
advanced
fields
tissue
regeneration,
vitro
models,
large-scale
differentiation,
immunotherapy,
gene
therapy.
However,
field
still
its
infancy,
discoveries
about
nature
cell–microenvironment
interactions
continue
to
overturn
much
early
progress
field.
Key
challenges
be
dissecting
roles
chemistry,
structure,
mechanics,
electrophysiology
microenvironment,
understanding
harnessing
periodicity
drift
these
factors.
This
review
encapsulates
where
recent
advances
appear
leave
ever-shifting
state
art,
it
highlights
areas
which
substantial
potential
uncertainty
remain.
Science,
Journal Year:
2016,
Volume and Issue:
353(6304), P. 1157 - 1161
Published: Sept. 8, 2016
The
ability
of
cells
to
follow
gradients
extracellular
matrix
stiffness-durotaxis-has
been
implicated
in
development,
fibrosis,
and
cancer.
Here,
we
found
multicellular
clusters
that
exhibited
durotaxis
even
if
isolated
constituent
did
not.
This
emergent
mode
directed
collective
cell
migration
applied
a
variety
epithelial
types,
required
the
action
myosin
motors,
originated
from
supracellular
transmission
contractile
physical
forces.
To
explain
observed
phenomenology,
developed
generalized
clutch
model
which
local
stick-slip
dynamics
cell-matrix
adhesions
was
integrated
tissue
level
through
cell-cell
junctions.
Collective
is
far
more
efficient
than
single-cell
durotaxis;
it
thus
emerges
as
robust
mechanism
direct
during
wound
healing,
cancer
invasion.
Matrix Biology,
Journal Year:
2015,
Volume and Issue:
47, P. 54 - 65
Published: May 8, 2015
Physiological
tissue
repair
aims
at
restoring
the
mechano-protective
properties
of
extracellular
matrix.
Consequently,
redundant
regulatory
mechanisms
are
in
place
ensuring
that
remodeling
terminates
once
matrix
homeostasis
is
re-established.
If
these
fail,
stromal
cells
become
continuously
activated,
accumulate
excessive
amounts
stiff
matrix,
and
fibrosis
develops.
In
this
mini-review,
I
develop
hypothesis
mechanical
state
pro-fibrotic
transforming
growth
factor
(TGF)-β1
cooperate
to
regulate
activities
cells.
TGF-β1
stored
as
part
a
large
latent
complex
can
be
activated
by
cell
contractile
force
transmitted
integrins.
Matrix
straining
stiffening
lower
threshold
for
activation
increasing
resistance
pulling.
Different
elements
mechanism
pharmacologically
targeted
interrupt
positive
feedback
loop
fibrosis,
including
specific
integrins
protein
interactions.
