Systems vaccinology of the BNT162b2 mRNA vaccine in humans

Nature, Journal Year: 2021, Volume and Issue: 596(7872), P. 410 - 416

Published: July 12, 2021

Language: Английский

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Mechanisms of innate and adaptive immunity to the Pfizer-BioNTech BNT162b2 vaccine

Nature Immunology, Journal Year: 2022, Volume and Issue: 23(4), P. 543 - 555

Published: March 14, 2022

Language: Английский

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A blood atlas of COVID-19 defines hallmarks of disease severity and specificity

Cell, Journal Year: 2022, Volume and Issue: 185(5), P. 916 - 938.e58

Published: Jan. 21, 2022

Treatment of severe COVID-19 is currently limited by clinical heterogeneity and incomplete description specific immune biomarkers. We present here a comprehensive multi-omic blood atlas for patients with varying severity in an integrated comparison influenza sepsis versus healthy volunteers. identify signatures correlates host response. Hallmarks disease involved cells, their inflammatory mediators networks, including progenitor cells myeloid lymphocyte subsets, features the repertoire, acute phase response, metabolism, coagulation. Persisting activation involving AP-1/p38MAPK was feature COVID-19. The plasma proteome enabled sub-phenotyping into patient clusters, predictive outcome. Systems-based integrative analyses tensor matrix decomposition all modalities revealed groupings linked specificity compared to sepsis. Our approach will support future drug development, trial design, personalized medicine approaches

Language: Английский

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Epigenetic memory of coronavirus infection in innate immune cells and their progenitors

Cell, Journal Year: 2023, Volume and Issue: 186(18), P. 3882 - 3902.e24

Published: Aug. 1, 2023

Language: Английский

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Induction of trained immunity by influenza vaccination - impact on COVID-19

PLoS Pathogens, Journal Year: 2021, Volume and Issue: 17(10), P. e1009928 - e1009928

Published: Oct. 25, 2021

Non-specific protective effects of certain vaccines have been reported, and long-term boosting innate immunity, termed trained has proposed as one the mechanisms mediating these effects. Several epidemiological studies suggested cross-protection between influenza vaccination COVID-19. In a large academic Dutch hospital, we found that SARS-CoV-2 infection was less common among employees who had received previous vaccination: relative risk reductions 37% 49% were observed following during first second COVID-19 waves, respectively. The quadrivalent inactivated vaccine induced immunity program boosted immune responses against various viral stimuli fine-tuned anti-SARS-CoV-2 response, which may result in better protection Influenza led to transcriptional reprogramming monocytes reduced systemic inflammation. These immunological data argue for potential benefits COVID-19, future randomized trials are warranted test this possibility.

Language: Английский

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Trained immunity: adaptation within innate immune mechanisms

Physiological Reviews, Journal Year: 2022, Volume and Issue: 103(1), P. 313 - 346

Published: Aug. 18, 2022

The mechanisms underlying innate immune memory have been extensively explored in the last decades but are fact largely unknown. Although specificity of adaptive vertebrates is ensured through recombination immunoglobulin family genes and clonal expansion, basic cells’ nonspecific increased responsiveness rely on epigenetic, transcriptional, metabolic programs after transient stimulation. Changes these result enhanced to secondary challenges with a wide variety stimuli. This phenomenon termed “trained immunity” or “innate memory.” On one hand, trained immunity improves response infections vaccination, facilitating stronger responses protection against microbial Conversely, may contribute pathophysiology cardiovascular, autoinflammatory, neurodegenerative diseases. In this review, we gather current body knowledge field summarize foundations immunity, different cell types involved, its consequences for health disease, potential modulation as therapeutic tool.

Language: Английский

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Influenza vaccination reveals sex dimorphic imprints of prior mild COVID-19

Nature, Journal Year: 2023, Volume and Issue: 614(7949), P. 752 - 761

Published: Jan. 4, 2023

Language: Английский

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Transcriptional activation of Jun and Fos members of the AP‐1 complex is a conserved signature of immune aging that contributes to inflammaging

Aging Cell, Journal Year: 2023, Volume and Issue: 22(4)

Published: Feb. 24, 2023

Diverse mouse strains have different health and life spans, mimicking the diversity among humans. To capture conserved aging signatures, we studied long-lived C57BL/6J short-lived NZO/HILtJ by profiling transcriptomes epigenomes of immune cells from peripheral blood spleen young old mice. Transcriptional activation AP-1 transcription factor complex, particularly Fos, Junb, Jun genes, was most significant signature across tissues strains. ATAC-seq data analyses showed that chromatin around these genes more accessible with age there were significantly binding sites for TFs all tissues, targeting pro-inflammatory molecules including Il6. Age-related increases in JUN FOS factors also human data. Single-cell RNA-seq cell atlas Tabula Muris Senis expression increased B, T, NK cells, macrophages, macrophages mice expressing abundantly than other cells. Functional upon myeloid via poly(I:C), levels protein its activity compared to In addition, activation, produced IL6 sum, aging-related transcriptional Fos family members complex is long- short-living strains, possibly contributing inflammation age.

Language: Английский

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The immunopathogenesis of narcolepsy type 1

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 24(1), P. 33 - 48

Published: July 3, 2023

Language: Английский

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BCG vaccination stimulates integrated organ immunity by feedback of the adaptive immune response to imprint prolonged innate antiviral resistance

Nature Immunology, Journal Year: 2023, Volume and Issue: 25(1), P. 41 - 53

Published: Nov. 30, 2023

Language: Английский

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