Advances in Clinical Medicine, Journal Year: 2025, Volume and Issue: 15(03), P. 364 - 376
Published: Jan. 1, 2025
Language: Английский
Gut, Journal Year: 2024, Volume and Issue: 73(11), P. 1893 - 1908
Published: Sept. 25, 2024
The understanding that changes in microbiome composition can influence chronic human diseases and the efficiency of therapies has driven efforts to develop microbiota-centred such as first next generation probiotics, prebiotics postbiotics, microbiota editing faecal transplantation. Central research is how disease impacts vice versa, yet there a problematic issue with term 'dysbiosis', which broadly links microbial imbalances various illnesses without precision or definition. Another significant discussions defining 'healthy individuals' ascertain what characterises healthy microbiome. This involves questioning who represents healthiest segment our population-whether it those free from illnesses, athletes at peak performance, individuals living healthily through regular exercise good nutrition even elderly adults centenarians have been tested by time achieved remarkable longevity.This review advocates for delineating 'what defines microbiome?' considering broader range factors related health environmental influences on microbiota. A undoubtedly linked gut health. Nevertheless, very difficult pinpoint universally accepted definition 'gut health' due complexities measuring functionality besides composition. We must take into account individual variabilities, diet, lifestyle, host factors. Moreover, challenge distinguishing causation correlation between overall presented.The also highlights resource-heavy nature comprehensive assessments, hinders their practicality broad application. Finally, we call continued nuanced approach better understand intricate evolving concept health, emphasising need more precise inclusive definitions methodologies studying
Language: Английский
Citations
49
Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2133 - 2147
Published: July 31, 2024
Language: Английский
Citations
27
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: July 1, 2024
Functional gastrointestinal disorders (FGIDs), chronic characterized by either abdominal pain, altered intestinal motility, or their combination, have a worldwide prevalence of more than 40% and impose high socioeconomic burden with significant decline in quality life. Recently, FGIDs been reclassified as gut-brain interaction (DGBI), reflecting the key role bidirectional communication these impact on psychological comorbidities. Although, during past decades, field DGBIs has advanced significantly, molecular mechanisms underlying pathogenesis pathophysiology, gut microbiome processes are not fully understood. This review aims to discuss latest body literature complex microbiota-gut-brain interactions implications DGBIs. A better understanding existing pathways between brain holds promise developing effective therapeutic interventions for
Language: Английский
Citations
11
Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)
Published: July 24, 2024
Commensal microorganisms in the human gut produce numerous metabolites by using small molecules derived from host or diet as precursors. Host dietary lipid are involved energy metabolism and maintaining structural integrity of cell membranes. Notably, microbes can convert these lipids into bioactive signaling through their biotransformation synthesis pathways. These microbiota-derived affect physiology influencing body's immune metabolic processes. This review aims to summarize recent advances microbial transformation immunomodulatory functions metabolites, with a special focus on fatty acids steroids produced our microbiota.
Language: Английский
Citations
11
Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 216 - 216
Published: Jan. 8, 2025
Chronic gut dysbiosis due to a high-fat diet (HFD) instigates cardiac remodeling and heart failure with preserved ejection fraction (HFpEF), in particular, kidney/volume-dependent HFpEF. Studies report that although mitochondrial ATP citrate lyase (ACLY) supports function, it decreases more human HFpEF than HFrEF. Interestingly, ACLY synthesizes lipids creates hyperlipidemia. Epigenetically, acetylates histone. The mechanism(s) are largely unknown. One hypothesis is an HFD induces epigenetic folate 1-carbon metabolism (FOCM) homocystinuria. This abrogates dipping sleep-time blood pressure causes hypertension morning attacks. We observed probiotics/lactobacillus utilize fat/lipids post-biotically, increasing bioenergetics attenuating suggest novel paradigm-shift sulfur trans-sulfuration pathways selectively target HFD-induced Previous studies from our laboratory, using single-cell analysis, revealed increase the transporter (SLC25A) of s-adenosine-methionine (SAM) during elevated levels homocysteine (Hcy, i.e., homocystinuria, HHcy), consequence impaired recycling Hcy back methionine FOCM methylation H3K4, K9, H4K20, gene writer (DNMT) decrease eraser (TET/FTO). transported mitochondria by SLC7A for clearance via metabolomic 3-mercaptopyruvate transferase (3MST). conclude disrupts rhythmic memory increases DNMT1 leading bioenergetics. treatment lactobacillus metabolites post-biotically bi-directionally produces folic acid lactone-ketone body mitigates
Language: Английский
Citations
1
International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 297, P. 139863 - 139863
Published: Jan. 13, 2025
Language: Английский
Citations
1
Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12
Published: Jan. 31, 2025
Atherosclerosis, the leading cause of death worldwide, is a chronic inflammatory disease to accumulation lipid-rich plaques in intima large and medium-sized arteries. Accumulating evidence indicates important regulatory role adaptive immune system atherosclerosis during all stages disease. The gut microbiome has also become key regulator immunomodulation. Whilst existing research extensively explores impact on innate system, only handful studies have explored capacity modulate atherogenesis. Building these concepts pitfalls microbiota response interaction, this review potential strategies therapeutically target microbiome, including use prebiotics vaccinations, which could influence consequently plaque composition development.
Language: Английский
Citations
1
The Lancet, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 1, 2024
Language: Английский
Citations
6
Physiological Reports, Journal Year: 2024, Volume and Issue: 12(12)
Published: June 1, 2024
Although the liver is largest metabolic organ in body, it not alone functionality and assisted by "an inside an organ," gut microbiota. This review attempts to shed light on partnership between microbiota metabolism of macronutrients (i.e., proteins, carbohydrates, lipids). All nutrients absorbed small intestines are delivered for further metabolism. Undigested food that enters colon metabolized produces secondary metabolites, which into portal circulation reach liver. These microbiota-derived metabolites co-metabolites include ammonia, hydrogen sulfide, short-chain fatty acids, bile trimethylamine N-oxide. Further, several compounds, such as acids can alter microbial composition, turn influence health. focuses these their host physiology. Furthermore, briefly delineates effect portosystemic shunt microbiota-liver axis, current understanding treatments target axis.
Language: Английский
Citations
4
ACS Chemical Biology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
As an important receptor in a host's immune and metabolic systems, NOD1 is usually activated by Gram-negative bacteria having
Language: Английский
Citations
0