Neurobiology of Disease,
Journal Year:
2023,
Volume and Issue:
183, P. 106164 - 106164
Published: May 20, 2023
Phototherapy
is
an
emerging
non-pharmacological
treatment
for
depression,
circadian
rhythm
disruptions,
and
neurodegeneration,
as
well
pain
conditions
including
migraine
fibromyalgia.
However,
the
mechanism
of
phototherapy-induced
antinociception
not
understood.
Here,
using
fiber
photometry
recordings
population-level
neural
activity
combined
with
chemogenetics,
we
found
that
phototherapy
elicits
via
regulation
ventral
lateral
geniculate
body
(vLGN)
located
in
visual
system.
Specifically,
both
green
red
lights
caused
increase
c-fos
vLGN,
light
increased
more.
In
causes
a
large
glutamatergic
neurons,
whereas
GABAergic
neurons.
Green
preconditioning
increases
sensitivity
neurons
to
noxious
stimuli
vLGN
PSL
mice.
produces
by
activating
promotes
nociception
vLGN.
Together,
these
results
demonstrate
different
colors
exert
modulation
effects
regulating
subpopulations
This
may
provide
potential
new
therapeutic
strategies
targets
precise
clinical
neuropathic
pain.
PLoS Biology,
Journal Year:
2023,
Volume and Issue:
21(9), P. e3002282 - e3002282
Published: Sept. 7, 2023
Light
in
the
environment
greatly
impacts
a
variety
of
brain
functions,
including
sleep.
Clinical
evidence
suggests
that
bright
light
treatment
has
beneficial
effect
on
stress–related
diseases.
Although
stress
can
alter
sleep
patterns,
stress–induced
alterations
and
underlying
mechanism
are
poorly
understood.
Here,
we
show
reduces
increase
nonrapid
eye
movement
(NREM)
induced
by
chronic
through
di–synaptic
visual
circuit
consisting
thalamic
ventral
lateral
geniculate
nucleus
intergeniculate
leaflet
(vLGN/IGL),
habenula
(LHb),
rostromedial
tegmental
(RMTg).
Specifically,
causes
marked
NREM
duration
complementary
decrease
wakefulness
time
mice.
Specific
activation
RMTg–projecting
LHb
neurons
or
RMTg
receiving
direct
inputs
mimics
effects
while
inhibition
sleep–promoting
stress.
Importantly,
demonstrate
vLGN/IGL–LHb–RMTg
pathway.
Together,
our
results
provide
Cell Reports,
Journal Year:
2023,
Volume and Issue:
42(4), P. 112287 - 112287
Published: March 22, 2023
During
the
visual
critical
period
(CP),
sensory
experience
refines
structure
and
function
of
circuits.
The
basis
this
plasticity
was
long
thought
to
be
limited
cortical
circuits,
but
recently
described
thalamic
challenges
dogma
demonstrates
greater
complexity
underlying
plasticity.
Yet
how
modulates
neurons
or
thalamus
CP
timing
is
incompletely
understood.
Using
a
larval
zebrafish,
thalamus-centric
ocular
dominance
model,
we
show
functional
changes
in
role
inhibitory
signaling
establish
using
combination
imaging,
optogenetics,
pharmacology.
Hemisphere-specific
genetically
defined
correlate
with
visuomotor
behavior,
establishing
modulating
motor
performance.
Our
work
that
broadly
conserved
leads
neuron-level
require
timing.
Cell Reports,
Journal Year:
2023,
Volume and Issue:
42(9), P. 113037 - 113037
Published: Aug. 24, 2023
The
superior
colliculus
(SC)
is
a
sensorimotor
structure
in
the
midbrain
that
integrates
input
from
multiple
sensory
modalities
to
initiate
motor
commands.
It
undergoes
well-characterized
steps
of
circuit
assembly
during
development,
rendering
mouse
SC
popular
model
study
establishment
neural
connectivity.
Here
we
perform
single-nucleus
RNA-sequencing
analysis
isolated
at
various
developmental
time
points.
Our
provides
transcriptomic
landscape
cell
types
comprise
across
murine
development
with
particular
emphasis
on
neuronal
heterogeneity.
We
report
repertoire
genes
differentially
expressed
different
postnatal
ages,
many
which
are
known
regulate
axon
guidance
and
synapse
formation.
Using
these
data,
find
Pax7
expression
restricted
subset
GABAergic
neurons.
data
provide
valuable
resource
for
interrogating
mechanisms
identifying
markers
manipulating
specific
populations
circuits.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 28, 2025
Abstract
In
addition
to
its
well-established
role
in
vision,
environmental
light
also
plays
a
crucial
non-image-forming
visual
functions,
including
the
regulation
of
instinctive
behaviors
such
as
feeding.
Clinical
evidence
suggests
that
bright
therapy
can
alleviate
symptoms
individuals
with
obesity.
However,
neural
mechanisms
underlying
influence
on
feeding
remain
poorly
understood.
this
study,
we
demonstrate
treatment
effectively
reduces
food
intake
and
mitigates
weight
gain
mice
through
circuit
involving
lateral
hypothalamic
area
(LHA).
Specifically,
subset
SMI-32-expressing
ON-type
retinal
ganglion
cells
(RGCs)
innervate
GABAergic
neurons
ventral
geniculate
nucleus
(vLGN),
which
turn
inhibits
LHA.
Activation
both
vLGN-projecting
RGCs
vLGN-to-LHA
pathway
is
sufficient
suppress
consumption
attenuate
gain.
Importantly,
provide
direct
suppressive
effects
rely
activation
retina-vLGN-LHA
pathway.
Together,
our
results
delineate
an
LHA-related
consumption-suppressing
gain-attenuating
treatment.
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: March 29, 2025
Abstract
The
central
amygdala
(CeA)
plays
a
crucial
role
in
defensive
and
appetitive
behaviours.
It
contains
genetically
defined
GABAergic
neuron
subpopulations
distributed
over
three
anatomical
subregions,
capsular
(CeC),
lateral
(CeL),
medial
(CeM).
roles
that
these
molecularly-
anatomically-defined
CeA
neurons
play
behavior
remain
unclear.
Using
intersectional
genetics
mice,
we
found
driving
food
or
water
consumption
are
confined
to
the
CeM.
Separate
CeM
exist
for
only
versus
consumption.
In
vivo
calcium
imaging
revealed
Htr2a
promoting
feeding
responsive
towards
cues
with
little
regard
their
physical
attributes.
Sst
involved
drinking
sensitive
properties
of
salient
stimuli.
Both
subtypes
receive
inhibitory
input
from
CeL
send
projections
parabrachial
nucleus
promote
behavior.
These
results
suggest
distinct
microcircuits
evaluate
liquid
solid
stimuli
drive
appropriate
behavioral
responses.
