Basic research on curcumin in cervical cancer: Progress and perspectives DOI Open Access

Xiaoyu Zhang,

Lin Zhu, Xuezhen Wang

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 162, P. 114590 - 114590

Published: March 23, 2023

Curcumin is a polyphenolic substance extracted from plants such as Curcuma longa, zedoaria, and radix curcumae, it has attracted much attention because of the anti-inflammatory, antioxidant, anti-tumor, antibacterial other multiple pharmacological effects. Cervical cancer one most common malignant tumors in women. With application HPV (human papillomavirus) vaccine, incidence cervical expected to be reduced, but remains difficult promote vaccine among low-income population. As commonly used food additive, curcumin recently been found have significant therapeutic effect treatment cancer. In recent years, numerous vitro vivo studies that can efficacy anti-cervical by promoting apoptosis, inhibiting tumour cell proliferation, metastasis invasion, inducing autophagy cells. However, due poor water solubility, rapid catabolism, low bioavailability curcumin, on derivatives novel formulations are increasing. wide range mechanisms action against may become antitumor drug future, opening up new ideas for research field antitumor. There lack systematic reviews mechanism Therefore, this study review literature based cancer, with view providing reference information scientific clinical practitioners.

Language: Английский

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research DOI Creative Commons

Xuhui Tong,

Rong Tang,

Mingming Xiao

et al.

Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)

Published: Dec. 8, 2022

Abstract Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various activities, including clearance aberrant cells. Thus, RCD pathways represented by apoptosis have increased in importance as a target development cancer medications recent years. However, because tumor show avoidance apoptosis, which causes treatment resistance recurrence, numerous studies been devoted alternative mortality processes, namely necroptosis, pyroptosis, ferroptosis, cuproptosis; these modalities extensively studied shown be crucial therapy effectiveness. Furthermore, evidence suggests that undergoing may alter immunogenicity microenvironment (TME) some extent, rendering it more suitable inhibiting progression metastasis. In addition, other components TME undergo abovementioned forms induce immune attacks on cells, resulting enhanced antitumor responses. Hence, this review discusses molecular processes features cuproptosis effects novel proliferation Importantly, introduces complex affect biology. It also summarizes potential agents nanoparticles or inhibit their therapeutic based from vivo vitro reports clinical trials inducers evaluated treatments patients. Lastly, we summarized impact modulating drug advantages adding modulators over conventional treatments.

Language: Английский

Citations

480
Artificial intelligence in cancer target identification and drug discovery DOI Creative Commons
Yujie You, Xin Lai, Yi Pan

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: May 10, 2022

Artificial intelligence is an advanced method to identify novel anticancer targets and discover drugs from biology networks because the can effectively preserve quantify interaction between components of cell systems underlying human diseases such as cancer. Here, we review discuss how employ artificial approaches drugs. First, describe scope analysis for target investigations. Second, basic principles theory commonly used network-based machine learning-based algorithms. Finally, showcase applications in cancer identification drug discovery. Taken together, models have provided us with a quantitative framework study relationship network characteristics cancer, thereby leading potential discovery candidates.

Language: Английский

Citations

219
Hypoxia, partial EMT and collective migration: Emerging culprits in metastasis DOI Creative Commons
Kritika Saxena, Mohit Kumar Jolly, Kuppusamy Balamurugan

et al.

Translational Oncology, Journal Year: 2020, Volume and Issue: 13(11), P. 100845 - 100845

Published: Aug. 8, 2020

Epithelial-mesenchymal transition (EMT) is a cellular biological process involved in migration of primary cancer cells to secondary sites facilitating metastasis. Besides, EMT also confers properties such as stemness, drug resistance and immune evasion which can aid successful colonization at the distant site. not binary process; recent evidence suggests that partial or hybrid E/M phenotype(s) have enhanced stemness compared those undergoing complete EMT. Moreover, enables collective clusters circulating tumor emboli, further endorsing phenotypes may be 'fittest' for Here, we review mechanisms implications phenotypes, including their reported association with hypoxia. Hypoxia-driven activation HIF-1α drive In addition, cyclic hypoxia, acute chronic shows highest levels active augment aggressiveness greater extent, enriching phenotype. We discuss how metastasis influenced by cell migration, call better understanding interconnections among these mechanisms. known regulators highlight gaps needs filled connecting three axes will increase our dynamics help control it more effectively.

Language: Английский

Citations

162
Circulating tumour cells for early detection of clinically relevant cancer DOI Open Access
Rachel Lawrence,

Melissa Watters,

Caitlin R. Davies

et al.

Nature Reviews Clinical Oncology, Journal Year: 2023, Volume and Issue: 20(7), P. 487 - 500

Published: June 2, 2023

Language: Английский

Citations

162
Tumor biomarkers for diagnosis, prognosis and targeted therapy DOI Creative Commons
Yue Zhou, Lei Tao, Jiahao Qiu

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: May 20, 2024

Abstract Tumor biomarkers, the substances which are produced by tumors or body’s responses to during tumorigenesis and progression, have been demonstrated possess critical encouraging value in screening early diagnosis, prognosis prediction, recurrence detection, therapeutic efficacy monitoring of cancers. Over past decades, continuous progress has made exploring discovering novel, sensitive, specific, accurate tumor significantly promoted personalized medicine improved outcomes cancer patients, especially advances molecular biology technologies developed for detection biomarkers. Herein, we summarize discovery development including history conventional innovative used biomarker classification biomarkers based on tissue origins, application clinical management. In particular, highlight recent advancements biomarker-based anticancer-targeted therapies emerging as breakthroughs promising strategies. We also discuss limitations challenges that need be addressed provide insights perspectives turn into opportunities this field. Collectively, multiple emphasized review may guidance precision medicine, broaden horizons future research directions, expedite patients according their rather than organs origin.

Language: Английский

Citations

148
Cancer Stem Cell Plasticity – A Deadly Deal DOI Creative Commons

Archana P. Thankamony,

Kritika Saxena,

Reshma Murali

et al.

Frontiers in Molecular Biosciences, Journal Year: 2020, Volume and Issue: 7

Published: April 30, 2020

Intratumoral heterogeneity is a major ongoing challenge in the effective therapeutic targeting of cancer. Accumulating evidence suggests that fraction cells within tumor termed Cancer Stem Cells (CSCs) are primarily responsible for this diversity resulting resistance and metastasis. Adding to complexity, recent studies have shown there can be different subpopulations CSCs with varying biochemical biophysical traits varied dissemination drug-resistance potential. Moreover, cancer exhibit high level plasticity or ability dynamically switch between CSC non-CSC statesoramong subsets CSCs. The molecular mechanisms underlying such has been under extensive investigation trans-differentiation process Epithelial Mesenchymal transition (EMT) identified as contributing factor. Besides genetic epigenetic factors, also shaped by non-cell-autonomous effects microenvironment. In review, we discuss developments understanding progression at levels,and latest silico approaches being taken characterizing cell implications improving existing approaches.

Language: Английский

Citations

139
The role of polyphenols in overcoming cancer drug resistance: a comprehensive review DOI Creative Commons
Parisa Maleki Dana,

Fatemeh Sadoughi,

Zatollah Asemi

et al.

Cellular & Molecular Biology Letters, Journal Year: 2022, Volume and Issue: 27(1)

Published: Jan. 3, 2022

Abstract Chemotherapeutic drugs are used to treat advanced stages of cancer or following surgery. However, cancers often develop resistance against drugs, leading failure treatment and recurrence the disease. Polyphenols a family organic compounds with more than 10,000 members which have three-membered flavan ring system in common. These natural known for their beneficial properties, such as free radical scavenging, decreasing oxidative stress, modulating inflammation. Herein, we discuss role polyphenols (mainly curcumin, resveratrol, epigallocatechin gallate [EGCG]) different aspects drug resistance. Increasing uptake by tumor cells, metabolism enzymes (e.g. cytochromes glutathione-S-transferases), reducing efflux some mechanisms increase sensitivity cells chemotherapeutic agents. also affect other targets overcoming chemoresistance including cell death (i.e. autophagy apoptosis), EMT, ROS, DNA repair processes, stem epigenetics miRNAs).

Language: Английский

Citations

131
Effects of Resveratrol, Curcumin and Quercetin Supplementation on Bone Metabolism—A Systematic Review DOI Open Access
Alessio Danilo Inchingolo, Angelo Michele Inchingolo, Giuseppina Malcangi

et al.

Nutrients, Journal Year: 2022, Volume and Issue: 14(17), P. 3519 - 3519

Published: Aug. 26, 2022

Phenolic compounds are natural phytochemicals that have recently reported numerous health benefits. Resveratrol, curcumin, and quercetin received the most attention among these molecules due to their documented antioxidant effects. The review aims investigate effects of on bone metabolism role in several diseases such as osteopenia osteoporosis, tumours, periodontitis. PubMed/Medline, Web Science, Google Scholar, Scopus, Cochrane Library, Embase electronic databases were searched for papers line with study topic. According an English language restriction, screening period was from January 2012 3 July 2022, following Boolean keywords: (“resveratrol” AND “bone”); (“curcumin” (“quercetin” “bone”). A total 36 identified relevant purpose our investigation. studies positive investigated phenolic potential application adjuvant treatments Furthermore, use titanium surfaces orthopaedic prostheses could represent a possible improve osteogenic processes osseointegration. findings, resveratrol, wide variety beneficial supplement therapies. seem positively mediate osteoclast-related pathologies.

Language: Английский

Citations

85
Neutrophil elastase: From mechanisms to therapeutic potential DOI Creative Commons

Weilin Zeng,

Yingqiu Song,

Runze Wang

et al.

Journal of Pharmaceutical Analysis, Journal Year: 2023, Volume and Issue: 13(4), P. 355 - 366

Published: Jan. 7, 2023

Neutrophil elastase (NE), a major protease in the primary granules of neutrophils, is involved microbicidal activity. NE an important factor promoting inflammation, has bactericidal effects, and shortens inflammatory process. also regulates tumor growth by metastasis microenvironment remodeling. However, plays role killing tumors under certain conditions promotes other diseases such as pulmonary ventilation dysfunction. Additionally, it complex various physiological processes mediates several diseases. Sivelestat, specific inhibitor, strong potential for clinical application, particularly treatment coronavirus disease 2019 (COVID-19). This review discusses pathophysiological associated with applications sivelestat.

Language: Английский

Citations

72
Involvement of lncRNAs in cancer cells migration, invasion and metastasis: cytoskeleton and ECM crosstalk DOI Creative Commons
Mohammad Ahmad, Louis‐Bastien Weiswald, Laurent Poulain

et al.

Journal of Experimental & Clinical Cancer Research, Journal Year: 2023, Volume and Issue: 42(1)

Published: July 18, 2023

Cancer is the main cause of death worldwide and metastasis a major poor prognosis cancer-associated mortality. Metastatic conversion cancer cells multiplex process, including EMT through cytoskeleton remodeling interaction with TME. Tens thousands putative lncRNAs have been identified, but biological functions most are still to be identified. However, already emerged as key regulators gene expression at transcriptional post-transcriptional level control in spatio-temporal fashion. LncRNA-dependent mechanisms can cell fates during development their perturbed associated onset progression many diseases cancer. LncRNAs involved each step different modes action. The investigation roles could possibly lead identification new biomarkers innovative therapeutic options.

Language: Английский

Citations

61