Journal of Agricultural and Food Chemistry,
Journal Year:
2022,
Volume and Issue:
70(29), P. 8855 - 8870
Published: July 14, 2022
Traditional
incineration
and
landfill
of
food
processing
waste
(FPW)
have
polluted
the
environment
underutilized
valuable
bioactive
compounds,
including
polyphenols
in
waste.
As
one
most
widely
occurring
compounds
FPW,
possess
high
utilization
value
many
fields
such
as
human
health,
energy,
environmental
protection.
Extracting
directly
from
FPW
can
maximize
avoid
resources.
However,
traditional
polyphenol
extraction
methods
mostly
use
Soxhlet
extraction,
infiltration,
impregnation
method,
consuming
a
large
amount
organic
solvent
suffering
long
time
low
efficiency.
Emerging
green
supercritical
fluid
ultrasonic-assisted
microwave-assisted
other
shorten
improve
efficacy,
resulting
safe
recovery
FPW.
In
this
paper,
treatment
application
are
briefly
reviewed,
emerging
compared
to
obtain
insight
into
start-of-the-art
approaches.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(6), P. 2536 - 2536
Published: March 10, 2023
Polyphenols
are
an
important
component
of
plant-derived
food
with
a
wide
spectrum
beneficial
effects
on
human
health.
For
many
years,
they
have
aroused
great
interest,
especially
due
to
their
antioxidant
properties,
which
used
in
the
prevention
and
treatment
diseases.
Unfortunately,
as
any
chemical
substance,
depending
conditions,
dose,
interactions
environment,
it
is
possible
for
polyphenols
also
exert
harmful
effects.
This
review
presents
comprehensive
current
state
knowledge
negative
impact
health,
describing
side
polyphenol
intake,
form
supplements.
The
begins
brief
overview
physiological
role
potential
use
disease
prevention,
followed
by
exerted
particular
situations.
individual
chapters
discuss
consequences
polyphenols’
ability
block
iron
uptake,
some
subpopulations
can
be
harmful,
well
inhibition
digestive
enzymes,
intestinal
microbiota,
polyphenolic
compounds
drugs,
hormonal
balance.
Finally,
prooxidative
activity
mutagenic,
carcinogenic,
genotoxic
presented.
According
authors,
there
need
raise
public
awareness
about
supplementation,
case
vulnerable
subpopulations.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 1000 - 1000
Published: Feb. 25, 2024
Quercetin
is
a
flavonoid
with
low
molecular
weight
that
belongs
to
the
human
diet’s
phenolic
phytochemicals
and
nonenergy
constituents.
has
potent
antioxidant
capacity,
being
able
capture
reactive
oxygen
species
(ROS),
nitrogen
(RNS),
chlorine
(ROC),
which
act
as
reducing
agents
by
chelating
transition-metal
ions.
Its
structure
five
functional
hydroxyl
groups,
work
electron
donors
are
responsible
for
capturing
free
radicals.
In
addition
its
different
pharmacological
properties
of
quercetin
have
been
described,
such
carcinostatic
properties;
antiviral,
antihypertensive,
anti-inflammatory
ability
protect
low-density
lipoprotein
(LDL)
oxidation,
inhibit
angiogenesis;
these
developed
in
this
review.
European Journal of Medicinal Chemistry,
Journal Year:
2023,
Volume and Issue:
250, P. 115197 - 115197
Published: Feb. 10, 2023
The
resistance
of
cancer
cells
to
chemotherapeutic
drugs
greatly
reduces
the
therapeutic
effect
in
patients,
and
toxic
side
effects
caused
by
chemotherapy
also
seriously
affect
quality
life
patients.
combination
epigallocatechin-3-gallate
(EGCG),
main
active
ingredient
tea,
with
cisplatin,
5-FU,
doxorubicin
paclitaxel
enhances
their
sensitizing
on
tumors
combats
drug
cells.
These
seem
be
mediated
a
variety
mechanisms,
including
combating
stem
cells,
enhancing
sensitivity,
inducing
cell
cycle
arrest
apoptosis,
blocking
angiogenesis.
In
addition,
EGCG
can
suppress
series
adverse
chemotherapy,
such
as
gastrointestinal
disorders,
nephrotoxicity
cardiotoxicity,
through
its
anti-inflammatory
antioxidant
improve
However,
low
bioavailability
off-target
reactivity
some
agents
limit
clinical
application.
nanomodification
not
only
antitumor
activity
but
prolongs
survival
time
tumor-bearing
mice,
has
advantage
toxicity.
Therefore,
this
review
aims
discuss
current
status
challenges
regarding
use
treatment
cancer.
general,
is
promising
adjuvant
for
chemotherapy.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
165, P. 115170 - 115170
Published: July 21, 2023
Breast
cancer
is
a
leadingcause
of
cancer-related
deaths
in
women
globally,
with
triple-negative
breast
(TNBC)
being
an
aggressive
subtype
that
lacks
targeted
therapies
and
associated
poor
prognosis.
Polyphenols,
naturally
occurring
compounds
plants,
have
been
investigated
as
potential
therapeutic
strategy
for
TNBC.
This
review
provides
overview
the
anticancer
effects
polyphenols
TNBC
their
mechanisms
action.
Several
polyphenols,
including
resveratrol,
quercetin,
kaempferol,
genistein,
epigallocatechin-3-gallate,
apigenin,
fisetin,
hesperetin
luteolin,
shown
to
inhibit
cell
proliferation,
induce
cycle
arrest,
promote
apoptosis,
suppress
migration/invasion
preclinical
models.
The
molecular
underlying
involve
modulation
several
signalling
pathways,
such
PI3K/Akt,
MAPK,
STATT,
NF-κB
pathways.
Polyphenols
also
exhibit
synergistic
chemotherapy
drugs,
making
them
promising
candidates
combination
therapy.
highlights
clinical
trials
investigating
use
individually
or
therapy,
against
cancer.
deepens
under-standing
mechanism
action
respective
valuable
insights
into
TNBC,
lays
groundwork
future
research
this
area.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: April 10, 2024
Cancer
is
a
severe
disease
that
results
in
death
all
countries
of
the
world.
A
nano-based
drug
delivery
approach
best
alternative,
directly
targeting
cancer
tumor
cells
with
improved
cellular
uptake.
Different
types
nanoparticle-based
carriers
are
advanced
for
treatment
cancer,
and
to
increase
therapeutic
effectiveness
safety
therapy,
many
substances
have
been
looked
into
as
carriers.
Lipid-based
nanoparticles
(LBNPs)
significantly
attracted
interest
recently.
These
natural
biomolecules
alternate
other
polymers
frequently
recycled
medicine
due
their
amphipathic
properties.
Lipid
typically
provide
variety
benefits,
including
biocompatibility
biodegradability.
This
review
covers
different
classes
LBNPs,
characterization
synthesis
technologies.
discusses
most
significant
advancements
lipid
nanoparticle
technology
use
administration.
Moreover,
also
emphasized
applications
used
types.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(10), P. 5556 - 5556
Published: May 20, 2024
The
most
common
malignancy
in
women
is
breast
cancer.
During
the
development
of
cancer,
oncogenic
transcription
factors
facilitate
overproduction
inflammatory
cytokines
and
cell
adhesion
molecules.
Antiapoptotic
proteins
are
markedly
upregulated
cancer
cells,
which
promotes
tumor
development,
metastasis,
survival.
Promising
findings
have
been
found
studies
on
cycle-mediated
apoptosis
pathway
for
medication
treatment.
Dietary
phytoconstituents
studied
great
detail
their
potential
to
prevent
by
triggering
body’s
defense
mechanisms.
underlying
mechanisms
action
may
be
clarified
considering
role
polyphenols
important
signaling
pathways.
Phenolic
acids,
flavonoids,
tannins,
coumarins,
lignans,
lignins,
naphthoquinones,
anthraquinones,
xanthones,
stilbenes
examples
natural
chemicals
that
being
anticancer
drugs.
These
substances
also
vital
This
review
focuses
innovations
study
polyphenol
genistein’s
effects
cells
presents
integrated
chemical
biology
methods
harness
therapeutic
advances.
Cells,
Journal Year:
2024,
Volume and Issue:
13(5), P. 441 - 441
Published: March 2, 2024
Oxidative
stress
refers
to
the
imbalance
between
production
of
reactive
oxygen
species
(ROS)
and
endogenous
antioxidant
defense
system.
Its
involvement
in
cell
senescence,
apoptosis,
series
diseases
has
been
demonstrated.
Advances
carcinogenic
research
have
revealed
oxidative
as
a
pivotal
pathophysiological
pathway
tumorigenesis
be
involved
lung
cancer,
glioma,
hepatocellular
carcinoma,
leukemia,
so
on.
This
review
combs
effects
on
each
phase
fate
determination,
three
features
are
discussed.
takes
part
processes
ranging
from
tumor
death
via
pathways
like
mitochondrial
stress,
endoplasmic
reticulum
ferroptosis.
It
can
affect
by
engaging
complex
relationships
death,
cancer.
The
influence
progression
is
multi-stage
interlaced
process
that
includes
two
aspects
promotion
inhibition,
with
mitochondria
core
regulation.
A
deeper
more
comprehensive
understanding
conducive
exploring
therapies.
Quercetin
is
a
flavonoid
with
low
molecular
weight
that
belongs
to
the
human
diet's
phenolic
phytochemicals
and
non-energy
constituents.
has
potent
antioxidant
capacity,
being
able
capture
Reactive
Oxygen
Species
(ROS),
reactive
nitro-gen
species
(RNS),
Chlorine
(ROC),
which
act
as
reducing
agents
by
chelating
transition
metal
ions.
Its
structure
five
functional
hydroxyl
groups,
work
electron
donors
are
responsible
for
capturing
free
radicals.
In
addition
its
it
was
described
different
pharmacological
properties
of
Quercetin,
such
carcinostatic
properties,
antiviral,
antihypertensive,
anti-inflammatory,
protection
Low-Density
Lipoprotein
(LDL)
oxidation,
inhibi-tion
angiogenesis
developed
in
this
review.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(5), P. 1093 - 1093
Published: Feb. 29, 2024
Luteolin,
a
flavonoid,
is
mainly
found
in
various
vegetables
and
fruits,
including
carrots,
cabbages,
onions,
parsley,
apples,
broccoli,
peppers.
Extensive
research
vivo
vitro
has
been
performed
to
explore
its
role
disease
prevention
treatment.
Moreover,
this
compound
possesses
the
ability
combat
cancer
by
modulating
cell-signaling
pathways
across
types
of
cancer.
The
studies
have
confirmed
that
luteolin
can
inhibit
cancer-cell
survival
proliferation,
angiogenesis,
invasion,
metastasis,
mTOR/PI3K/Akt,
STAT3,
Wnt/β-catenin,
cell-cycle
arrest,
induce
apoptosis.
Further,
scientific
evidence
describes
plays
vital
up/down-regulation
microRNAs
(miRNAs)
therapy.
This
review
aims
outline
anti-cancer
mechanisms
molecular
targets.
However,
knowledge
gap
remains
regarding
on
safety
efficacy
clinical
trials.
Therefore,
it
essential
conduct
more
based
safety,
efficacy,
trials
beneficial
management,
