Gastroenterology, Journal Year: 2022, Volume and Issue: 163(3), P. 637 - 648.e2
Published: May 25, 2022
Language: Английский
Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 10
Published: Feb. 19, 2021
The gastrointestinal microbiota is a multi-faceted system that unraveling novel contributors to the development and progression of several diseases. Berberine has been used treat obesity, diabetes mellitus, atherosclerosis, metabolic diseases in China. There are also clinical trials regarding berberine use cardiovascular, gastrointestinal, endocrine elicits benefits at standard doses low toxicity. mechanism underlying role lipid‐lowering insulin resistance incompletely understood, but one possible mechanisms related its effect on microbiota. An extensive search electronic databases (PubMed, Scopus, Embase, Web Sciences, Science Direct) was identify treatment. aim this review summarize pharmacologic effects animals humans by regulation
Language: Английский
Citations
73
Frontiers in Cellular and Infection Microbiology, Journal Year: 2021, Volume and Issue: 11
Published: Dec. 13, 2021
Colorectal cancer (CRC) is a heterogeneous disease that commonly affects individuals aged more than 50 years old globally. Regular colorectal screening, which recommended for and above, has decreased the number of death toll over years. However, CRC incidence increased among younger population (below old). Environmental factors, such as smoking, dietary factor, urbanization, sedentary lifestyle, obesity, may contribute to rising trend early-onset (EOCRC) because lack genetic susceptibility. Research focused on role gut microbiota its interaction with epithelial barrier genes in sporadic CRC. Population consumption grain vegetables showed high abundance Prevotella , reduces risk Microbes, Fusobacterium nucleatum Bacteroides fragilis Escherichia coli deteriorate intestinal barrier, leads infiltration inflammatory mediators chemokines. Gut dysbiosis also occur following inflammation clearly observed animal model. Both pre- or post-inflammatory process cause major alteration morphology functional properties tissue explain pathological outcome EOCRC. The precise mechanism progression from an early stage until establishment not fully understood. We hypothesized dysbiosis, be influenced by environmental induce changes genome, metabolome, immunome could destruct function. Also, possible underlying give impact microbial community leading disruption physical barrier. This review explains potential host microenvironment, microbiota, provide answer
Language: Английский
Citations
71
The Journal of Nutritional Biochemistry, Journal Year: 2021, Volume and Issue: 94, P. 108623 - 108623
Published: March 9, 2021
Language: Английский
Citations
61
Frontiers in Oncology, Journal Year: 2022, Volume and Issue: 12
Published: Feb. 11, 2022
Colorectal cancer (CRC) is a leading cause of morbidity and mortality worldwide. The etiology pathogenesis CRC remain unclear. A growing body evidence suggests dysbiosis gut bacteria can contribute to the occurrence development by generating harmful metabolites changing host physiological processes. Metabolomics, systems biology method, will systematically study changes in processes body, eventually playing significant role detection metabolic biomarkers improving disease diagnosis treatment. particular, has been highly beneficial tracking microbially derived metabolites, which substantially advanced our comprehension host-microbiota interactions CRC. This paper briefly compiled recent research progress alterations intestinal flora its associated with application association analysis metabolomics microbiome diagnosis, prevention, treatment CRC; furthermore, we discuss prospects for problems direction this Gut microbiota their influence progression causation CRC, provide novel strategies therapy
Language: Английский
Citations
58
Gastroenterology, Journal Year: 2022, Volume and Issue: 163(3), P. 637 - 648.e2
Published: May 25, 2022
Language: Английский
Citations
50