iScience, Journal Year: 2025, Volume and Issue: 28(4), P. 112221 - 112221
Published: March 14, 2025
Language: Английский
Journal of Translational Medicine, Journal Year: 2022, Volume and Issue: 20(1)
Published: July 6, 2022
Abstract In recent years, there has been a greater emphasis on the impact of microbial populations inhabiting gastrointestinal tract human health and disease. According to involvement microbiota in modulating physiological processes (such as immune system development, vitamins synthesis, pathogen displacement, nutrient uptake), any alteration its composition diversity (i.e., dysbiosis) linked variety pathologies, including cancer. this bidirectional relationship, colonization with various bacterial species is correlated reduced or elevated risk certain cancers. Notably, gut microflora could potentially play direct indirect role tumor initiation progression by inducing chronic inflammation producing toxins metabolites. Therefore, identifying involved their mechanism action be beneficial preventing onset tumors controlling advancement. Likewise, community affects anti-cancer approaches’ therapeutic potential adverse effects immunotherapy chemotherapy). Hence, efficiency should evaluated context microbiome, underlining importance personalized medicine. review, we summarized evidence revealing microbiota's cancer mechanism. We also delineated how predict colon carcinoma development response current treatments improve clinical outcomes.
Language: Английский
Citations
79
Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14
Published: Sept. 26, 2023
Toll-like receptors (TLRs) serve as the body’s first line of defense, recognizing both pathogen-expressed molecules and host-derived released from damaged or dying cells. The wide distribution different cell types, ranging epithelial to immune cells, highlights crucial roles TLRs in linking innate adaptive immunity. Upon stimulation, binding mediates expression several adapter proteins downstream kinases, that lead induction other signaling such key pro-inflammatory mediators. Indeed, extraordinary progress immunobiological research has suggested could represent promising targets for therapeutic intervention inflammation-associated diseases, autoimmune microbial infections well human cancers. So far, prevention possible treatment inflammatory various TLR antagonists/inhibitors have shown be efficacious at stages pre-clinical evaluation clinical trials. Therefore, fascinating role modulating responses levels directed scientists opt these sensor suitable developing chemotherapeutics immunotherapeutics against cancer. Hitherto, TLR-targeting small (e.g., Pam3CSK4, Poly (I:C), (A:U)), chemical compounds, phytocompounds Curcumin), peptides, antibodies been found confer protection types However, administration inappropriate doses TLR-modulating therapeutics a wrong infusion is reported induce detrimental outcomes. This review summarizes current findings on molecular structural biology gives an overview potency promises TLR-directed strategies cancers by discussing established pipeline discoveries.
Language: Английский
Citations
65
Gastroenterology, Journal Year: 2022, Volume and Issue: 163(4), P. 862 - 874
Published: June 24, 2022
Language: Английский
Citations
65
Frontiers in Cellular and Infection Microbiology, Journal Year: 2022, Volume and Issue: 12
Published: Oct. 26, 2022
Accumulating evidence suggests that selected microbiota-derived metabolites play a significant role in both tumor prevention and supportive treatment of cancer. Short-chain fatty acids (SCFAs), i.e., mainly acetate, proprionate, butyrate, are one them. Nowadays, it is known butyrate key microbial metabolite. Therefore, the current review, we focused on sodium (NaB) context colorectal Notably, characterized by wide range beneficial properties/activities. Among others, influences function immune system, maintains intestinal barrier integrity, positively affects efficiency anti-cancer treatment, may reduce risk mucositis induced chemotherapy. Taking into consideration these facts, analyzed NaB (which salt butyric acid) its impact gut microbiota as well anti-tumor activity describing molecular mechanisms. Overall, available as, for instance, food with special medical purposes (depending country’s regulation), administration seems to be promising option cancer patients.
Language: Английский
Citations
42
Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 251, P. 114543 - 114543
Published: Jan. 12, 2023
Lead exposure is a global public health safety issue that severely disrupts brain development and causes damage to the nervous system in early life. Probiotics gut microbes have been highlighted for their critical roles mitigating lead toxicity. However, underlying mechanisms by which they work yet be fully explored. Here, we designed two-stage experiment using probiotic Lactobacillus fermentum HNU312 (Lf312) uncover how probiotics alleviate toxicity during First, explored tolerance adsorption of Lf312 vitro. Second, capacity strain was determined confirmed vivo. The shotgun metagenome sequencing showed exposure-induced imbalance dysfunction microbiome. In contrast, intake significantly modulated structure microbiome, increased abundance beneficial bacteria short-chain fatty acids (SCFAs)-producing bacteria, upregulated function-related metabolic pathways such as antioxidants. Notably, enhanced integrity blood-brain barrier increasing levels SCFAs gut, alleviated inflammation brain, ultimately improved anxiety-like depression-like behaviours induced mice. Subsequently, effective mechanism confirmed, highlighting worked through integrated strategies, including ionic microbiota-gut-brain axis regulation. Collectively, this elucidated microbiota mitigates toxic effects provides preventive measures intervention due mass poisoning children.
Language: Английский
Citations
31
Microbiological Research, Journal Year: 2023, Volume and Issue: 272, P. 127392 - 127392
Published: April 25, 2023
Language: Английский
Citations
31
Cancer Letters, Journal Year: 2024, Volume and Issue: 598, P. 217096 - 217096
Published: July 4, 2024
Language: Английский
Citations
11
Cells, Journal Year: 2024, Volume and Issue: 13(17), P. 1437 - 1437
Published: Aug. 27, 2024
The gut microbiota plays an essential role in maintaining immune homeostasis and influencing the landscape within tumor microenvironment. This review aims to elucidate interactions between dynamics, with a focus on colorectal cancer (CRC). spans foundational concepts of immuno-microbial interplay, factors microbiome composition, evidence linking immunotherapy outcomes. Gut modulates anti-cancer immunity through several mechanisms, including enhancement surveillance modulation inflammatory responses. Specific microbial species their metabolic byproducts can significantly influence efficacy immunotherapies. Furthermore, diversity correlates clinical outcomes CRC, suggesting potential as valuable biomarker for predicting response immunotherapy. Conclusions: Understanding relationship responses offers novel therapeutic strategies development. not only influences natural history treatment CRC but also serves critical modulator activity. Further exploration into microbiome's could enhance effectiveness existing treatments guide development new modalities.
Language: Английский
Citations
10
Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Feb. 9, 2024
Abstract Background Overweight is known to be an important risk factor for colorectal cancer (CRC), and the differences in intestinal flora among CRC patients with different BMI status have not been clearly defined. The purpose of this study was elucidate abundance, composition biological function status. Method A total 170 were included grouped according data patients. ≥ 24 kg/m 2 defined as overweight group, within range 18.5–23.9 normal weight group. Preoperative stool collection both groups used 16S rRNA sequencing. Total RNA extracted from 17 tumor tissue samples transcriptome sequencing, then CIBERSORT algorithm convert into relative content matrix 22 kinds immune cells, correlation between cells immune-related genes under states analyzed. Finally, we identified BMI-related differential functional pathways analyzed these flora. Result There no significant difference α diversity β analysis group Partial least square discriminant (PLS-DA) could divide two clusters stratification. 33 by linear effect size (LEfSe), which Actinomyces, Desulfovibrio Bacteroides significantly enriched ko00514: Other types O-glycan biosynthesis are a positive Clostridium IV Macrophages M2 T regulatory (Tregs). negative Dendritic activated CD4 memory activated. Conclusions richness may related status, enrichment Desulphurvibrio microenvironment resides has landscapes, suggesting that some affect process regulating cell infiltration gene expression, but further experiments needed confirm this.
Language: Английский
Citations
8
Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 100 - 100
Published: Jan. 3, 2025
The gut microbiota, a dynamic ecosystem of trillions microorganisms, produces secondary metabolites that profoundly influence host health. Recent research has highlighted the significant role these metabolites, particularly short-chain fatty acids, indoles, and bile in modulating immune responses, impacting epigenetic mechanisms, contributing to disease processes. In gastrointestinal (GI) cancers such as colorectal, liver, gastric cancer, microbial can drive tumorigenesis by promoting inflammation, DNA damage, evasion. Conversely, same hold therapeutic promise, potentially enhancing responses chemotherapy immunotherapy even directly suppressing tumor growth. addition, play crucial roles infectious susceptibility resilience, mediating pathways impact pathogen resistance. By consolidating recent insights into microbiota's shaping health, this review underscores potential targeting microbiome-derived for treating GI diseases calls further microbiome-based interventions.
Language: Английский
Citations
1