The additive interaction of healthy lifestyles and genetic susceptibility on colorectal cancer risk in prediabetes: a large population-based prospective cohort study DOI Creative Commons

Wang Wen-chen,

Yikang Cheng, Qingyu Meng

et al.

BMC Gastroenterology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 18, 2024

We aimed to investigate the interrelationships among polygenic risk scores (PRS), healthy lifestyle factors (HLFs), and colorectal cancer (CRC) in individuals with prediabetes. To whether adherence HLFs influence CRC those elevated PRS within this specific population. Data from 22,408 prediabetes participants without at baseline were analyzed UK Biobank. graded using (HLSs) classified as favorable, intermediate, or unfavorable, while for was categorized high, medium, low. Cox proportional hazards models used calculate hazard ratios (HR) 95% confidence intervals (CI) risk. High (HR: 2.36; CI: 1.86–3.00) medium 1.42; 1.09–1.83) associated increased compared low PRS. linked lower a dose–response manner, never smoking 0.69; 0.57–0.84) maintaining BMI 0.64; 0.49–0.82) reduced Adherence favorable may reduce 0.51; 0.27–0.95) high 0.62; 0.39–0.99) over 15 years of follow-up. In unfavorable HLFs, excess due additive interaction between 1.41% (p < 0.01), especially women (1.07%). There is an on Adopting should be integrated into management CRC.

Language: Английский

Changing epidemiology of colorectal cancer — birth cohort effects and emerging risk factors DOI
Caitlin C. Murphy, Timothy A. Zaki

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 21(1), P. 25 - 34

Published: Sept. 18, 2023

Language: Английский

Citations

66
Risk factors for early-onset colorectal cancer: systematic review and meta-analysis DOI Creative Commons

Hongmei Hua,

Qiuping Jiang,

Pan Sun

et al.

Frontiers in Oncology, Journal Year: 2023, Volume and Issue: 13

Published: May 5, 2023

Background The incidence of early-onset colorectal cancer (EOCRC), which means diagnosed in patients under 50 years, has been increasing around the world. However, etiology remains unclear. This study aims to identify risk factors for EOCRC. Methods systematic review was conducted PubMed, Embase, Scopus, and Cochrane Library databases from inception November 25, 2022. We examined EOCRC, including demographic factors, chronic conditions, lifestyle behaviors or environmental factors. Random-effects/fixed-effects meta-analysis adopted combine effect estimates published data. Study quality evaluated with Newcastle-Ottawa Scale (NOS). Statistical analysis performed Revman5.3. Studies not suitable were analyzed by a review. Results A total 36 studies identified this review, 30 included meta-analysis. Significant EOCRC male (OR=1.20; 95% CI, 1.08-1.33), Caucasian (OR=1.44; 1.15-1.80), family history CRC (OR=5.90; 3.67-9.48), inflammatory bowel disease (OR=4.43; 4.05-4.84), obesity (OR=1.52; 95%CI, 1.20-1.91), overweight (OR=1.18; 1.12-1.25), triglycerides (OR=1.12; 1, 08-1.18), hypertension (OR=1.16; 1.12-1.21), metabolic syndrome (OR=1.29; 1.15-1.45), smoking 1.10-1.88), alcohol consumption (OR=1.41; 1.22-1.62), sedentary (OR=1.24; 1.05-1.46), red meat (OR=1.10; 1.04-1.16), processed (OR=1.53; 1.13-2.06), Western dietary patterns (OR=1.43; 1.18-1.73) sugar-sweetened beverages (OR=1.55; 1.23-1.95). no statistical differences found hyperlipidemia hyperglycemia. Vitamin D may be protective factor (OR=0.72; 0.56-0.92). There considerable heterogeneity among (I 2 &gt;60%). Conclusions provides an overview Current evidence can provide baseline data prediction models specific risk-tailored screening strategies.

Language: Английский

Citations

53
Recent Advancements, Limitations, and Future Perspectives of the use of Personalized Medicine in Treatment of Colon Cancer DOI Creative Commons

Amit Dey,

Abhijit Mitra, Surajit Pathak

et al.

Technology in Cancer Research & Treatment, Journal Year: 2023, Volume and Issue: 22

Published: Jan. 1, 2023

Due to the heterogeneity of colon cancer, surgery, chemotherapy, and radiation are ineffective in all cases. The genomic profile biomarkers associated with process considered personalized medicine, along patient's personal history. It is based on response targeted therapies specific genetic variations. transcriptomic epigenetic features evaluated, best therapeutic approach diagnostic testing identified through medicine. This review aims summarize necessary, updated information cancer related Personalized medicine gaining prominence as generalized treatments finding it challenging contain cases which currently rank fourth among global incidence while being fifth largest total death worldwide. In therapy, patients grouped into categories, chosen evaluating their molecular features. Various strategies explored treatment involving immunotherapy, phytochemicals, other biomarker-specific therapies. However, significant challenges must be overcome integrate healthcare systems completely. We look at various signaling pathways alterations understand identify useful therapy. current available improve existing methods discussed. highlights advantages limitations scenario developed countries faced middle- low-income also summarized. Finally, we discuss future perspectives how could integrated systems.

Language: Английский

Citations

50
Effects of Helicobacter pylori infection on intestinal microbiota, immunity and colorectal cancer risk DOI Creative Commons
Veronika Engelsberger, Markus Gerhard, Raquel Mejías‐Luque

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 26, 2024

Infecting about half of the world´s population, Helicobacter pylori is one most prevalent bacterial infections worldwide and strongest known risk factor for gastric cancer. Although H. colonizes exclusively epithelium, infection has also been associated with various extragastric diseases, including colorectal cancer (CRC). Epidemiological studies reported an almost two-fold increased infected individuals to develop CRC, but only recently, direct causal functional links between chronic CRC have revealed. Besides modulating host intestinal immune response, thought increase by inducing gut microbiota alterations. It that not impacts at site leads changes in colonization distal large intestine. Considering microbiome plays a driving role emerges as key responsible promoting signatures could contribute tumor development. Within this review, we want focus on interplay infection, microbiota, immunity. In addition, effects antibiotic eradication therapy will be discussed.

Language: Английский

Citations

31
Big Data Research for Diabetes-Related Diseases Using the Korean National Health Information Database DOI Creative Commons
Kyung‐Soo Kim, Bongseong Kim, Kyungdo Han

et al.

Diabetes & Metabolism Journal, Journal Year: 2025, Volume and Issue: 49(1), P. 13 - 21

Published: Jan. 1, 2025

The Korean National Health Information Database (NHID), which contains nationwide real-world claims data including sociodemographic data, health care utilization screening and healthcare provider information, is a powerful resource to test various hypotheses. It also longitudinal in nature due the recommended checkup every 2 years appropriate for long-term follow-up study as well evaluating relationships between outcomes changes parameters such lifestyle factors, anthropometric measurements, laboratory results. However, because these are not collected research purposes, precise operational definitions of diseases required facilitate big analysis using NHID. In this review, we describe characteristics NHID, used related diabetes, introduce representative diabetes-related

Language: Английский

Citations

1
Sex and Tumor-Site Differences in the Association of Alcohol Intake With the Risk of Early-Onset Colorectal Cancer DOI Creative Commons
Eun Hyo Jin, Kyungdo Han, Cheol Min Shin

et al.

Journal of Clinical Oncology, Journal Year: 2023, Volume and Issue: 41(22), P. 3816 - 3825

Published: June 14, 2023

PURPOSE Given the increasing incidence of early-onset colorectal cancer (CRC; diagnosed before age 50 years) worldwide, it is important to identify modifiable risk factors. We investigated whether alcohol consumption in young population correlated with an increased CRC that differed by tumor location and sex. PATIENTS AND METHODS association between average daily among 5,666,576 individuals 20-49 years using data from Korean National Health Insurance Service (2009-2019). Alcohol levels nondrinker, light (reference), moderate, heavy drinker were defined as 0, <10, 10 <30, ≥30 g/d for men <20, ≥20 women, respectively. Multivariate Cox proportional hazards models used estimate adjusted hazard ratios (aHRs) 95% CIs. RESULTS identified 8,314 incident cases during follow-up period. Moderate drinkers showed compared (aHR, 1.09 [95% CI, 1.02 1.16] aHR, 1.20 1.11 1.29], respectively). Subgroup analysis positive dose-response significance distal colon rectal cancers, but not proximal cancer. The drinking frequency was significant, a 7%, 14%, 27% 1-2, 3-4, ≥5 d/wk nondrinkers, CONCLUSION Excessive increases onset years. Thus, effective interventions are required discourage people tailor screening approaches high-risk individuals.

Language: Английский

Citations

15
Obesity and early-onset colorectal cancer risk: emerging clinical evidence and biological mechanisms DOI Creative Commons
Peng Xu, Tao Zuo,

Hua Yang

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: May 2, 2024

Early-onset colorectal cancer (EOCRC) is defined as diagnosed at younger than 50 years of age and indicates a health burden globally. Patients with EOCRC have distinct risk factors, clinical characteristics, molecular pathogenesis compared older patients CRC. Further investigations identified different roles obesity between late-onset (LOCRC). Most studies focused on the characteristics in EOCRC, therefore, mechanism involved association remains inconclusive. This review further states that affects carcinogenesis well its development progression, which may lead to obesity-related metabolic syndrome, intestinal dysbacteriosis, inflammation.

Language: Английский

Citations

5
Colon cancer transcriptome DOI

Khatere Mokhtari,

Maryam Peymani, Mohsen Rashidi

et al.

Progress in Biophysics and Molecular Biology, Journal Year: 2023, Volume and Issue: 180-181, P. 49 - 82

Published: April 13, 2023

Language: Английский

Citations

12
The heterogeneity of metabolic syndrome presentation and challenges this causes in its pharmacological management: a narrative review focusing on principal risk modifiers DOI
Amedeo Lonardo

Expert Review of Clinical Pharmacology, Journal Year: 2023, Volume and Issue: 16(10), P. 891 - 911

Published: Sept. 19, 2023

Metabolic syndrome (MetS), i.e. the cluster of cardiometabolic risk factors comprising visceral obesity, impaired glucose metabolism, arterial hypertension and atherogenic dyslipidemia, is prevalent globally exacts a heavy toll on health care expenditures.The pathophenotypes individual traits MetS in adults are discussed first, with strong emphasis nonalcoholic fatty liver disease (NAFLD) sex differences. Next, I discuss recent studies phenotypic outcome heterogeneity MetS, highlighting role NAFLD, sex, reproductive status, depressive disorders. In second half article, therapeutic implications variable types features analyzed, focusing most developments, guidelines.I have identified physiological, pathological, social medical sources phenotypical its constitutive traits. Improved understanding these variables may be utilized setting future precision medicine approaches field metabolic disorders target organ damage.

Language: Английский

Citations

12
Association between depression and young-onset dementia in middle-aged women DOI Creative Commons
Jung Eun Yoo, Dae Hyun Yoon, Eun Hyo Jin

et al.

Alzheimer s Research & Therapy, Journal Year: 2024, Volume and Issue: 16(1)

Published: June 26, 2024

Abstract Background Dementia is associated with older adults; however, it can also affect younger individuals, known as young-onset dementia (YOD), when diagnosed before the age of 65 years. We aimed to conduct a retrospective cohort study involving middle-aged women investigate association between premorbid depression and YOD development. Methods included 1.6 million aged 40–60 years who underwent health checkups under Korean National Health Insurance Service investigated YOD. Results Women had significantly higher risk developing than without depression. Among premenopausal women, those 2.67-fold increased risk, whereas postmenopausal 2.50-fold risk. Late at menarche (> 16 years) young menopause (< 40 was an Conclusions Depression in significant factor for development Understanding role reproductive factors aid targeted therapeutic interventions prevent or delay

Language: Английский

Citations

4