Nutrients,
Journal Year:
2021,
Volume and Issue:
13(6), P. 2045 - 2045
Published: June 15, 2021
Living
longer
is
associated
with
an
increased
risk
of
chronic
diseases,
including
impairments
the
musculoskeletal
and
immune
system
as
well
metabolic
disorders
certain
cancers,
each
which
can
negatively
affect
relationship
between
host
microbiota
up
to
occurrence
dysbiosis.
On
other
hand,
lifestyle
factors,
regular
physical
exercise
a
healthy
diet,
skeletal
muscle
aging
positively
at
all
ages.
Accordingly,
health
benefits
could
partly
depend
on
effect
such
interventions
that
influence
biodiversity
functionality
intestinal
microbiota.
In
present
review,
we
first
discuss
physiological
effects
gut
microbiota,
system,
muscle.
Secondly,
describe
human
epidemiological
evidence
about
associations
activity
fitness
composition
in
older
adults.
The
third
part
highlights
relevance
restorative
mechanisms
protection
through
specific
during
aging.
Fourth,
important
research
findings
protein
nutrients
performance
Finally,
provide
nutritional
recommendations
prevent
malnutrition
support
active
focus
Key
nutrition-related
concerns
include
need
for
adequate
energy
intake
preventing
low
mass
higher
demand
(e.g.,
dietary
fiber,
polyphenols
polyunsaturated
fatty
acids)
modify
composition,
diversity,
capacity
may
thus
practical
means
enhancing
systemic
function.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: June 8, 2023
Abstract
Aging
is
characterized
by
systemic
chronic
inflammation,
which
accompanied
cellular
senescence,
immunosenescence,
organ
dysfunction,
and
age-related
diseases.
Given
the
multidimensional
complexity
of
aging,
there
an
urgent
need
for
a
systematic
organization
inflammaging
through
dimensionality
reduction.
Factors
secreted
senescent
cells,
known
as
senescence-associated
secretory
phenotype
(SASP),
promote
inflammation
can
induce
senescence
in
normal
cells.
At
same
time,
accelerates
immune
resulting
weakened
function
inability
to
clear
cells
inflammatory
factors,
creates
vicious
cycle
senescence.
Persistently
elevated
levels
organs
such
bone
marrow,
liver,
lungs
cannot
be
eliminated
leading
damage
aging-related
Therefore,
has
been
recognized
endogenous
factor
elimination
could
potential
strategy
anti-aging.
Here
we
discuss
at
molecular,
cellular,
organ,
disease
levels,
review
current
aging
models,
implications
cutting-edge
single
cell
technologies,
well
anti-aging
strategies.
Since
preventing
alleviating
diseases
improving
overall
quality
life
are
ultimate
goals
research,
our
highlights
critical
features
mechanisms
along
with
latest
developments
future
directions
providing
theoretical
foundation
novel
practical
Critical Reviews in Food Science and Nutrition,
Journal Year:
2020,
Volume and Issue:
62(13), P. 3509 - 3534
Published: Dec. 30, 2020
Aging
is
characterized
by
the
functional
decline
of
tissues
and
organs
increased
risk
aging-associated
disorders,
which
pose
major
societal
challenges
are
a
public
health
priority.
Despite
extensive
human
genetics
studies,
limited
progress
has
been
made
linking
with
aging.
There
growing
realization
that
altered
assembly,
structure
dynamics
gut
microbiota
actively
participate
in
aging
process.
Age-related
microbial
dysbiosis
involved
reshaping
immune
responses
during
aging,
manifest
as
immunosenescence
(insufficiency)
inflammaging
(over-reaction)
accompany
many
age-associated
enteric
extraenteric
diseases.
The
can
be
regulated,
suggesting
potential
target
for
interventions.
This
review
summarizes
recent
findings
on
physiological
succession
across
life-cycle,
roles
mechanisms
healthy
alterations
diseases,
microbiota-targeted
anti-aging
strategies.
Nature Communications,
Journal Year:
2021,
Volume and Issue:
12(1)
Published: Nov. 19, 2021
Abstract
The
incidence
of
sporadic
young-onset
colorectal
cancer
(yCRC)
is
increasing.
A
significant
knowledge
gap
exists
in
the
gut
microbiota
and
its
diagnostic
value
for
yCRC
patients.
Through
16S
rRNA
gene
sequencing,
728
samples
are
collected
to
identify
microbial
markers,
an
independent
cohort
310
used
validate
results.
Furthermore,
species-level
functional
analysis
performed
by
metagenome
sequencing
using
200
samples.
Gut
diversity
increased
yCRC.
Flavonifractor
plautii
important
bacterial
species
yCRC,
while
genus
Streptococcus
contains
key
phylotype
old-onset
cancer.
Functional
reveals
that
has
unique
characteristics
metabolism
characterized
dominance
DNA
binding
RNA-dependent
biosynthetic
process.
random
forest
classifier
model
achieves
a
powerful
classification
potential.
This
study
highlights
potential
biomarkers
as
promising
non-invasive
tool
accurate
detection
distinction
individuals
with
