Polyfunctional antibodies: a path towards precision vaccines for vulnerable populations DOI Creative Commons
Ruth A Purcell, Robert M. Theisen, Kelly B. Arnold

et al.

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: June 27, 2023

Vaccine efficacy determined within the controlled environment of a clinical trial is usually substantially greater than real-world vaccine effectiveness. Typically, this results from reduced protection immunologically vulnerable populations, such as children, elderly individuals and people with chronic comorbidities. Consequently, these high-risk groups are frequently recommended tailored immunisation schedules to boost responses. In addition, diverse healthy adults may also be variably protected by same regimen. Current population-based vaccination strategies that consider basic parameters offer glimpse into what achievable if more nuanced aspects immune response considered in design. To date, development has been largely empirical. However, next-generation approaches require rational strategies. We foresee generation precision vaccines mechanistic basis variations associated both immunogenetic baseline health differences. Recent efforts have highlighted importance balanced extra-neutralising antibody functions for vaccine-induced protection. significant modulation polyfunctional responses mediate neutralisation effector observed. Here, we review current understanding key genetic inflammatory modulators polyfunctionality affect outcomes how knowledge harnessed tailor design improved public health.

Language: Английский

Early-life interactions between the microbiota and immune system: impact on immune system development and atopic disease DOI
Katherine Donald, B. Brett Finlay

Nature reviews. Immunology, Journal Year: 2023, Volume and Issue: 23(11), P. 735 - 748

Published: May 3, 2023

Language: Английский

Citations

145
Microbial transmission, colonisation and succession: from pregnancy to infancy DOI Creative Commons
Liwen Xiao, Fangqing Zhao

Gut, Journal Year: 2023, Volume and Issue: 72(4), P. 772 - 786

Published: Jan. 31, 2023

The microbiome has been proven to be associated with many diseases and used as a biomarker target in disease prevention intervention. Currently, the vital role of pregnant women newborns is increasingly emphasised. In this review, we discuss interplay corresponding immune mechanism between mothers their offspring during perinatal period. We aim present comprehensive picture microbial transmission potential imprinting before after delivery. addition, possibility utero colonisation pregnancy, which highly debated recent studies, highlight importance infant development first 3 years life. This holistic view infants will refine our current understanding pregnancy complications well early life greatly facilitate microbiome-based prenatal diagnosis treatment mother-infant-related diseases.

Language: Английский

Citations

80
Gut microbiome and breast-feeding: Implications for early immune development DOI Creative Commons
Erin C. Davis,

Vanessa P Castagna,

David A. Sela

et al.

Journal of Allergy and Clinical Immunology, Journal Year: 2022, Volume and Issue: 150(3), P. 523 - 534

Published: Sept. 1, 2022

Language: Английский

Citations

74
Comparing early life nutritional sources and human milk feeding practices: personalized and dynamic nutrition supports infant gut microbiome development and immune system maturation DOI Creative Commons

Spencer R. Ames,

Larisa Lotoski, Meghan B. Azad

et al.

Gut Microbes, Journal Year: 2023, Volume and Issue: 15(1)

Published: April 13, 2023

Exclusive breastfeeding is recommended for the first six months of life, but many infants receive pumped milk, formula, donor human or other nutritional sources during this critical period. Substantive evidence shows early nutrition influences development microbiome and immune system, affecting lifelong health. However, underlying mechanisms are unclear nuances milk feeding rarely considered. This review synthesizes from studies model systems to discuss impact different on co-development gut microbiome, antigen tolerance, immunity. We highlight two key mechanisms: epigenetics so-called "weaning reaction". Collectively, highlights i) fundamental role parents' own fed directly at breast, as a dynamic personalized source that drives developmental programming, ii) deficiencies alternative priority research areas improving these alternatives when direct not possible.

Language: Английский

Citations

56
The maternal gut microbiome in pregnancy: implications for the developing immune system DOI
Omry Koren, Liza Konnikova, Petter Brodin

et al.

Nature Reviews Gastroenterology & Hepatology, Journal Year: 2023, Volume and Issue: 21(1), P. 35 - 45

Published: Dec. 14, 2023

Language: Английский

Citations

56
Host control of the microbiome: Mechanisms, evolution, and disease DOI Creative Commons
Jacob Wilde, Emma Slack, Kevin R. Foster

et al.

Science, Journal Year: 2024, Volume and Issue: 385(6706)

Published: July 18, 2024

Many species, including humans, host communities of symbiotic microbes. There is a vast literature on the ways these microbiomes affect hosts, but here we argue for an increased focus how hosts their microbiomes. Hosts exert control over symbionts through diverse mechanisms, immunity, barrier function, physiological homeostasis, and transit. These mechanisms enable to shape ecology evolution generate natural selection microbial traits that benefit host. Our result from perpetual tension between symbiont evolution, can leverage host's evolved abilities regulate microbiota prevent treat disease. The study will be central our ability both understand manipulate microbiotas better health.

Language: Английский

Citations

25
Role of breastfeeding in disease prevention DOI Creative Commons
A Masi, Christopher J. Stewart

Microbial Biotechnology, Journal Year: 2024, Volume and Issue: 17(7)

Published: June 30, 2024

Human milk provides the infant with many bioactive factors, including immunomodulating components, antimicrobials and prebiotics, which modulate microbiome immune system maturation. As a result, breastfeeding can impact health from infancy, through adolescence, into adulthood. From protecting infections, to reducing risk of obesity, type 1 diabetes childhood leukaemia, positive outcomes are observed in infants receiving breastmilk. For mother, protects against postpartum bleeding depression, increases weight loss, long-term lowers 2 diabetes, breast ovarian cancer, cardiovascular diseases. Beyond mothers, wider society is also impacted because avoidable costs relating morbidity mortality derived lack human exposure. In this review, Medline was used search for relevant articles discuss benefits its societal before exploring future recommendations enhance our understanding mechanisms behind breastfeeding's effects promote on global scale.

Language: Английский

Citations

15
Shaping oral and intestinal microbiota and the immune system during the first 1,000 days of life DOI Creative Commons

Jie Zhu,

Mingxin He, Simin Li

et al.

Frontiers in Pediatrics, Journal Year: 2025, Volume and Issue: 13

Published: Jan. 21, 2025

The first 1, 000 days of life, from the fetal stage a woman's pregnancy to 2 years age after baby is born, critical period for microbial colonization body and development immune system. system microbiota exhibit great plasticity at this play crucial role in subsequent future health. Two-way communication interaction between helpful maintain human microecological balance homeostasis. Currently, there growing interest important newborn, it believed that absence or dysbiosis commensal early life can have lasting health consequences. Thus, paper summarizes research advances establishment oral intestinal microbiome emphasizing substantial impact diversity prenatal postnatal periods, maternal microbes, mode delivery, feeding practices, antibiotics, probiotics, environment shape infants their association with

Language: Английский

Citations

1
Microbiota during pregnancy and early life: role in maternal−neonatal outcomes based on human evidence DOI Creative Commons
Alessio Fasano, Benoît Chassaing, Dirk Haller

et al.

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Aug. 19, 2024

Here, we explored the vast potential of microbiome-based interventions in preventing and managing non-communicable diseases including obesity, diabetes, allergies, celiac disease, inflammatory bowel diseases, malnutrition, cardiovascular across different life stages. We discuss intricate relationship between microbiome emphasizing on "window opportunity" for microbe–host interactions during first years after birth. Specific biotics also live biotherapeutics fecal microbiota transplantation emerge as pivotal tools precision medicine, acknowledging "one size doesn't' fit all" aspect. Challenges implementation underscore need advanced technologies, scientific transparency, public engagement. Future perspectives advocate understanding maternal−neonatal microbiome, exploring maternal exposome delving into human milk's role establishment restoration infant its influence over health disease. An integrated approach, employing multi-omics accounting inter-individual variance composition function appears central to unleash full early-life revolutionizing healthcare.

Language: Английский

Citations

6
Breastfeeding Beyond Six Months: Evidence of Child Health Benefits DOI Open Access
Anita Froń, Magdalena Orczyk‐Pawiłowicz

Nutrients, Journal Year: 2024, Volume and Issue: 16(22), P. 3891 - 3891

Published: Nov. 14, 2024

Breastfeeding is globally recognized as the optimal method of infant nutrition, offering health benefits for both child and mother, making it a public priority. However, potential advantages breastfeeding extend well beyond initial months. Breast milk adapts to evolving needs growing infant, its immunological, microbiological, biochemical properties have been associated with enhanced protection against infections chronic diseases, improved growth development, lower rates hospitalization mortality. This review explores evidence supporting continuation six More meticulous studies employing consistent methodologies addressing confounders are essential. will enable more accurate determination extent mechanisms positive impact prolonged allow implementation effective strategies.

Language: Английский

Citations

5