International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 249, P. 126057 - 126057
Published: July 29, 2023
Language: Английский
Journal of Hematology & Oncology, Journal Year: 2022, Volume and Issue: 15(1)
Published: Sept. 12, 2022
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is considered one the obstacles in cancer therapy. To help overcome this, nanoscale drug delivery systems have provided an alternative avenue for improving therapeutic potential various agents and bioactive molecules through enhanced permeability retention (EPR) effect. Nanosystems with cancer-targeted ligands can achieve effective tumor cells utilizing cell surface-specific receptors, vasculature antigens high accuracy affinity. Additionally, stimuli-responsive nanoplatforms also been as a promising strategy against tumors, these maintain their stealth feature under conditions, but upon homing cancerous lesions or microenvironment, are responsive release cargoes. In this review, we comprehensively summarize field active number studies context emerging nanoplatform development, discuss how knowledge contribute further improvements clinical practice.
Language: Английский
Citations
246
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(9), P. 2233 - 2233
Published: Aug. 29, 2023
Targeted drug delivery is a precise and effective strategy in oncotherapy that can accurately deliver drugs to tumor cells or tissues enhance their therapeutic effect and, meanwhile, weaken undesirable side effects on normal tissues. In this research field, large number of researchers have achieved significant breakthroughs advances oncotherapy. Typically, nanocarriers as promising effectively the site through enhanced permeability retention (EPR) effect-mediated passive targeting various types receptor-mediated active targeting, respectively. Herein, we review recent targeted strategies technologies for enhancing addition, also two mainstream strategies, based therapy. Meanwhile, comparison combination are carried out. Furthermore, discuss associated challenges prospects further study.
Language: Английский
Citations
104
Materials Today Bio, Journal Year: 2022, Volume and Issue: 13, P. 100208 - 100208
Published: Jan. 1, 2022
Nanotechnology in medical applications, especially oncology as drug delivery systems, has recently shown promising results. However, although these advances have been the pre-clinical stages, clinical translation of this technology is challenging. To create systems with increased treatment efficacy for translation, physicochemical characteristics nanoparticles such size, shape, elasticity (flexibility/rigidity), surface chemistry, and charge can be specified to optimize efficiency a given application. Consequently, interdisciplinary researchers focused on producing biocompatible materials, production technologies, or new formulations efficient loading, high stability. The effects design parameters studied
Language: Английский
Citations
100
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1868 - 1868
Published: July 2, 2023
Cancer immunotherapy is an innovative treatment strategy to enhance the ability of immune system recognize and eliminate cancer cells. However, dose limitations, low response rates, adverse events pose significant challenges. To address these gold nanoparticles (AuNPs) have been explored as immunotherapeutic drug carriers owing their stability, surface versatility, excellent optical properties. This review provides overview advanced synthesis routes for AuNPs utilization improve precision therapies. The also emphasises various aspects AuNP-based immunotherapy, including loading, targeting strategies, release mechanisms. application combined with therapeutic efficacy are briefly discussed. Overall, we aimed provide a recent understanding advances, challenges, prospects anticancer applications.
Language: Английский
Citations
79
Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 31, 2025
Language: Английский
Citations
2
Journal of Nanobiotechnology, Journal Year: 2021, Volume and Issue: 19(1)
Published: Oct. 16, 2021
Abstract Chemodynamic therapy (CDT) catalyzed by transition metal and starvation intracellular metabolite oxidases are both classic tumor treatments based on nanocatalysts. CDT monotherapy has limitations including low catalytic efficiency of ions insufficient endogenous hydrogen peroxide (H 2 O ). Also, single shows limited ability resisting tumors. The “metal-oxidase” cascade system is to introduce into the metal-based nanoplatform, which perfectly solves shortcomings above-mentioned monotherapiesIn this system, can not only consume nutrients produce a “starvation effect”, but also provide with sufficient H suitable acidic environment, further promote synergy between therapy, leading enhanced antitumor effects. More importantly, be combined other therapies (such as photothermal hypoxia-activated drug chemotherapy, immunotherapy) maximize their In addition, nanoparticles activate immunity through multiple pathways, so combination immunotherapy powerful synergistic effect. This article firstly introduced metals induce then described in detail. Moreover, we highlight application numerous therapies, especially immunotherapy, expecting new ideas for treatment.
Language: Английский
Citations
73
Advanced Drug Delivery Reviews, Journal Year: 2022, Volume and Issue: 191, P. 114584 - 114584
Published: Oct. 21, 2022
Nanomedicine has been considered a promising tool for biomedical research and clinical practice in the 21st century because of great impact nanomaterials could have on human health. The generation new smart nanomaterials, which enable time- space-controlled drug delivery, improve limitations conventional treatments, such as non-specific targeting, poor biodistribution permeability. These can respond to internal biological stimuli (pH, enzyme expression redox potential) and/or external (such temperature, ultrasound, magnetic field light) further precision therapies. To this end, photonic nanoparticles, gold, silver iron oxide, used increase sensitivity responsiveness stimuli. In review, we aim report main most recent systems that involve or stimulus-responsive release. uniqueness review lies highlighting versatility integrating these materials within different carriers. This leads enhanced performance terms vitro vivo efficacy, stability toxicity. We also point out current regulatory challenges translation from bench bedside, well yet unresolved matter regarding standardization materials.
Language: Английский
Citations
50
Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 345, P. 832 - 850
Published: March 31, 2022
Language: Английский
Citations
48
Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 1113 - 1113
Published: May 23, 2022
Research into the application of nanocarriers in delivery cancer-fighting drugs has been a promising research area for decades. On other hand, their cytotoxic effects on cells, low uptake efficiency, and therapeutic resistance have limited use. However, urgency pressing healthcare needs resulted functionalization nanoparticles' (NPs) physicochemical properties to improve clinical outcomes new, old, repurposed drugs. This article reviews recent methods targeting functionalized nanoparticles tumor microenvironment (TME). Additionally, use relevant engineering techniques surface (liposomes, dendrimers, mesoporous silica) critical roles overcoming current limitations cancer therapy-targeting ligands used targeted delivery, stimuli strategies, multifunctional nanoparticles-were all reviewed. The future perspectives were also finally discussed. Using keywords, published scientific literature from credible sources was retrieved. A quick search yielded almost 400 publications. subject matter this review addressed adequately using an inclusion/exclusion criterion. content provides reasonable basis further studies fully exploit potential these therapy.
Language: Английский
Citations
45
Small, Journal Year: 2023, Volume and Issue: 19(23)
Published: March 12, 2023
Abstract Neurological diseases are the foremost cause of disability and second leading death worldwide. Owing to special microenvironment neural tissues biological characteristics cells, a considerable number neurological disorders currently incurable. In past few years, development nanoplatforms based on metal–organic frameworks (MOFs) has broadened opportunities for offering sensitive diagnosis/monitoring effective therapy neurology‐related diseases. this article, obstacles neurotherapeutics, including delayed diagnosis misdiagnosis, existence blood brain barrier (BBB), off‐target treatment, irrepressible inflammatory storm/oxidative stress, irreversible nerve cell summarized. Correspondingly, MOFs‐based diagnostic/monitoring strategies such as neuroimaging biosensors (electrochemistry, fluorometry, colorimetry, electrochemiluminescence, etc.) therapeutic higher BBB permeability, targeting specific lesion sites, attenuation neuroinflammation/oxidative stress well regeneration extensively highlighted management Finally, challenges present research from perspective clinical translation discussed, hoping facilitate interdisciplinary studies at intersections between neurotheranostics.
Language: Английский
Citations
35