Stealth and pseudo-stealth nanocarriers

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 198, P. 114895 - 114895

Published: May 19, 2023

Language: Английский

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Cancer Nanomedicine: Emerging Strategies and Therapeutic Potentials

Molecules, Journal Year: 2023, Volume and Issue: 28(13), P. 5145 - 5145

Published: June 30, 2023

Cancer continues to pose a severe threat global health, making pursuing effective treatments more critical than ever. Traditional therapies, although pivotal in managing cancer, encounter considerable challenges, including drug resistance, poor solubility, and difficulties targeting tumors, specifically limiting their overall efficacy. Nanomedicine's application cancer therapy signals new epoch, distinguished by the improvement of specificity, efficacy, tolerability treatments. This review explores mechanisms advantages nanoparticle-mediated delivery, highlighting passive active strategies. Furthermore, it transformative potential nanomedicine tumor therapeutics, delving into its applications across various treatment modalities, surgery, chemotherapy, immunotherapy, radiotherapy, photodynamic photothermal therapy, gene as well diagnosis imaging. Meanwhile, outlook therapeutics is discussed, emphasizing need for addressing toxicity concerns, improving delivery strategies, enhancing carrier stability controlled release, simplifying nano-design, exploring novel manufacturing technologies. Overall, integrating holds immense revolutionizing patient outcomes.

Language: Английский

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Lipid-based nanoparticles as drug delivery carriers for cancer therapy

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 10, 2024

Cancer is a severe disease that results in death all countries of the world. A nano-based drug delivery approach best alternative, directly targeting cancer tumor cells with improved cellular uptake. Different types nanoparticle-based carriers are advanced for treatment cancer, and to increase therapeutic effectiveness safety therapy, many substances have been looked into as carriers. Lipid-based nanoparticles (LBNPs) significantly attracted interest recently. These natural biomolecules alternate other polymers frequently recycled medicine due their amphipathic properties. Lipid typically provide variety benefits, including biocompatibility biodegradability. This review covers different classes LBNPs, characterization synthesis technologies. discusses most significant advancements lipid nanoparticle technology use administration. Moreover, also emphasized applications used types.

Language: Английский

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Regulating protein corona on nanovesicles by glycosylated polyhydroxy polymer modification for efficient drug delivery

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 7, 2024

Abstract The dynamic protein corona formed on nanocarriers has been revealed to strongly affect their in vivo behaviors. Precisely manipulating the formation of may provide an alternative impetus for specific drug delivery. Herein, we explore role glycosylated polyhydroxy polymer-modified nanovesicles (CP-LVs) with different amino/hydroxyl ratios and evolution. CP-LVs ratio approximately 0.4 (CP 1 -LVs) are found efficiently suppress immunoglobulin adsorption blood livers, resulting prolonged circulation. Moreover, CP -LVs adsorb abundant tumor distinctive proteins, such as CD44 osteopontin interstitial fluids, mediating selective cell internalization. proteins transformation environment appears be affected by electrostatic interaction between diverse isoelectric points. Benefiting from surface modification-mediated regulation, paclitaxel-loaded demonstrate superior antitumor efficacy PEGylated liposomes. Our work offers a perspective rational surface-design modulate efficient

Language: Английский

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Strategies to Promote the Journey of Nanoparticles Against Biofilm‐Associated Infections

Small, Journal Year: 2024, Volume and Issue: 20(10)

Published: Jan. 4, 2024

Abstract Biofilm‐associated infections are one of the most challenging healthcare threats for humans, accounting 80% bacterial infections, leading to persistent and chronic infections. The conventional antibiotics still face their dilemma poor therapeutic effects due high tolerance resistance led by biofilm barriers. Nanotechnology‐based antimicrobials, nanoparticles (NPs), paid attention extensively considered as promising alternative. This review focuses on whole journey NPs against biofilm‐associated clarify it clearly, is divided into four processes in sequence 1) Targeting biofilms, 2) Penetrating barrier, 3) Attaching cells, 4) Translocating through cell envelope. Through outlining compositions properties biofilms bacteria recent advances present strategies each process comprehensively discussed combat well combined these with drug resistance, aiming guide rational design facilitate wide application

Language: Английский

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Protein Coronas Derived from Mucus Act as Both Spear and Shield to Regulate Transferrin Functionalized Nanoparticle Transcellular Transport in Enterocytes

ACS Nano, Journal Year: 2024, Volume and Issue: 18(10), P. 7455 - 7472

Published: Feb. 28, 2024

The epithelial mucosa is a key biological barrier faced by gastrointestinal, intraoral, intranasal, ocular, and vaginal drug delivery. Ligand-modified nanoparticles demonstrate excellent ability on this process, but their efficacy diminished the formation of protein coronas (PCs) when they interact with matrices. PCs are broadly implicated in affecting fate NPs vivo vitro, yet few studies have investigated formed during interactions mucosa, especially mucus. In study, we constructed transferrin modified (Tf-NPs) as model explored mechanisms effects that had subsequent impact transcellular transport Tf-NPs. mucus-secreting cells, Tf-NPs adsorbed more proteins from mucus layers, which masked, displaced, dampened active targeting Tf-NPs, thereby weakening endocytosis efficiencies. mucus-free intracellular trafficking, enhanced transcytosis related functions. Inspired soft artificial biomimetic membranes, used mucin an "active PC" to precoat (M@Tf-NPs), limited negative impacts "passive PCs" interface improved favorable routes endocytosis. M@Tf-NPs associated endoplasmic reticulum-Golgi functions, prompting exocytosis. summary, shielded against absorption also could be employed spear break through barrier. These findings offer theoretical foundation design platform enhance efficiency oral-administered nanomedicines.

Language: Английский

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Zwitterionic Poly(ethylene glycol) Nanoparticles Minimize Protein Adsorption and Immunogenicity for Improved Biological Fate

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

We report the assembly of poly(ethylene glycol) nanoparticles (PEG NPs) and optimize their surface chemistry to minimize formation protein coronas immunogenicity for improved biodistribution. PEG NPs cross-linked with disulfide bonds are synthesized utilizing zeolitic imidazolate framework-8 as templates, which subsequently modified molecules different end groups (carboxyl, methoxy, or amino) vary chemistry. Among modifications, amino residual carboxyl form a pair zwitterionic structures on NPs, adsorption proteins (e.g., immunoglobulin, complement proteins) maximize blood circulation time. The influence preexisting antibodies in mice pharmacokinetics is negligible, demonstrates resistance anti-PEG inhibition accelerated clearance phenomenon. This research highlights importance PEGylated design delivery systems reveals translational potential cancer therapy.

Language: Английский

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The role of protein corona on nanodrugs for organ-targeting and its prospects of application

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 360, P. 15 - 43

Published: June 20, 2023

Language: Английский

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Application of Nanoparticles in Cancer Treatment: A Concise Review

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(21), P. 2887 - 2887

Published: Oct. 31, 2023

Timely diagnosis and appropriate antitumoral treatments remain of utmost importance, since cancer remains a leading cause death worldwide. Within this context, nanotechnology offers specific benefits in terms therapy by reducing its adverse effects guiding drugs to selectively target cells. In comprehensive review, we have summarized the most relevant novel outcomes range 2010-2023, covering design application nanosystems for therapy. We established general requirements nanoparticles be used drug delivery strategies their uptake tumor microenvironment vasculature, including reticuloendothelial system surface functionalization with protein corona. After brief review classes nanovectors, covered different therapies. First, advances encapsulation (such as paclitaxel fisetin) into nanoliposomes nanoemulsions are described, well relevance current clinical trials. Then, polymeric presented, namely ones comprising poly lactic-co-glycolic acid, polyethylene glycol (and PEG dilemma) dendrimers. The quantum dots bioimaging is also covered, systems zinc sulfide indium phosphide. Afterwards, reviewed gold (spheres anisotropic) plasmon-induced photothermal iron oxide nanoparticles, such magnetite maghemite, has been analyzed fields, magnetic resonance imaging, immunotherapy, hyperthermia, delivery. Lastly, recent using carbon nanomaterials, graphene oxide, nanotubes, fullerenes, dots. Finally, compared passive active targeting theranostics. This aims (nano)mark on ongoing journey towards realizing remarkable potential realm therapeutics.

Language: Английский

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Engineered Nanomaterials to Potentiate CRISPR/Cas9 Gene Editing for Cancer Therapy

Advanced Materials, Journal Year: 2023, Volume and Issue: 36(13)

Published: July 12, 2023

Abstract Clustered regularly interspaced short palindromic repeats/associated protein 9 (CRISPR/Cas9) gene‐editing technology shows promise for manipulating single or multiple tumor‐associated genes and engineering immune cells to treat cancers. Currently, most strategies rely on viral delivery; yet, while being efficient, many limitations, mainly from safety packaging capacity considerations, hinder the use of CRISPR vectors in cancer therapy. In contrast, recent advances non‐viral CRISPR/Cas9 nanoformulations have paved way better gene editing, as these can be engineered improve safety, efficiency, specificity through optimizing capacity, pharmacokinetics, targetability. this review, advance delivery is highlighted, there a discussion how approaches potentially used cancers addressing aforementioned followed by perspectives designing proper CRISPR/Cas9‐based nanomedicine system with translational potential.

Language: Английский

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