Tumor vaccines: Toward multidimensional anti-tumor therapies DOI Creative Commons
Yuanfang Tan, H. S. Chen,

Xi Gou

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2023, Volume and Issue: 19(3)

Published: Oct. 31, 2023

For decades, immunotherapies have offered hope for patients with advanced cancer. However, they show distinct benefits and limited clinical effects. Tumor vaccines the potential to prime tumor-antigen-specific T cells induce broad subsets of immune responses, ultimately eradicating tumor cells. Here, we classify by their anti-tumor mechanisms, which include boosting system, overcoming immunosuppression, modulating angiogenesis. We focus on multidimensional vaccine strategies using combinations two or three above as these are superior single-dimensional treatments. This review offers a perspective future role therapies in cancer treatment.

Language: Английский

Current advance of nanotechnology in diagnosis and treatment for malignant tumors DOI Creative Commons

Bilan Wang,

Shiqi Hu, Yan Teng

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 12, 2024

Cancer remains a significant risk to human health. Nanomedicine is new multidisciplinary field that garnering lot of interest and investigation. shows great potential for cancer diagnosis treatment. Specifically engineered nanoparticles can be employed as contrast agents in diagnostics enable high sensitivity high-resolution tumor detection by imaging examinations. Novel approaches labeling are also made possible the use nanoprobes nanobiosensors. The achievement targeted medication delivery therapy accomplished through rational design manufacture nanodrug carriers. Nanoparticles have capability effectively transport medications or gene fragments tissues via passive active targeting processes, thus enhancing treatment outcomes while minimizing harm healthy tissues. Simultaneously, context radiation sensitization photothermal enhance therapeutic efficacy malignant tumors. This review presents literature overview summary how nanotechnology used According oncological diseases originating from different systems body combining pathophysiological features cancers at sites, we most recent developments applications. Finally, briefly discuss prospects challenges cancer.

Language: Английский

Citations

99

Lipid-based nanoparticles as drug delivery carriers for cancer therapy DOI Creative Commons

Ibtesam Waheed,

Anwar Ali, Huma Tabassum

et al.

Frontiers in Oncology, Journal Year: 2024, Volume and Issue: 14

Published: April 10, 2024

Cancer is a severe disease that results in death all countries of the world. A nano-based drug delivery approach best alternative, directly targeting cancer tumor cells with improved cellular uptake. Different types nanoparticle-based carriers are advanced for treatment cancer, and to increase therapeutic effectiveness safety therapy, many substances have been looked into as carriers. Lipid-based nanoparticles (LBNPs) significantly attracted interest recently. These natural biomolecules alternate other polymers frequently recycled medicine due their amphipathic properties. Lipid typically provide variety benefits, including biocompatibility biodegradability. This review covers different classes LBNPs, characterization synthesis technologies. discusses most significant advancements lipid nanoparticle technology use administration. Moreover, also emphasized applications used types.

Language: Английский

Citations

35

Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds DOI
Yafei Zhang, Yuning Zhang, Rui Ding

et al.

Small, Journal Year: 2024, Volume and Issue: 20(26)

Published: Jan. 12, 2024

Abstract Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects BCs. NCs equally as BCs some extent. Self‐assembly (SA) methods build advantages than chemical methods, and SA significant impact on structure function NCs. However, relationship among mechanism, structure, not been given enough attention. Therefore, from perspective bottom‐up building concept SA‐structure‐function is emphasized promote SA‐based First, conditions forces for occurring introduced, then basis molecular mechanism protein, polysaccharide, lipid summarized. Then, varieties structures formed based introduced in detail. Finally, facing how be well solved by also elaborated. This review attempts describe great significance constructing artificial deliver aspects SA‐structure‐function, so wide application

Language: Английский

Citations

19

Solubilization techniques used for poorly water-soluble drugs DOI Creative Commons

Bing Xie,

Yaping Liu, Xiaotong Li

et al.

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(11), P. 4683 - 4716

Published: Sept. 2, 2024

About 40% of approved drugs and nearly 90% drug candidates are poorly water-soluble drugs. Low solubility reduces the drugability. Effectively improving bioavailability is a critical issue that needs to be urgently addressed in development application. This review briefly introduces conventional solubilization techniques such as solubilizers, hydrotropes, cosolvents, prodrugs, salt modification, micronization, cyclodextrin inclusion, solid dispersions, details crystallization strategies, ionic liquids, polymer-based, lipid-based, inorganic-based carriers bioavailability. Some most commonly used carrier materials for presented. Several using summarized. Furthermore, this summarizes mechanism each technique, reviews latest research advances challenges, evaluates potential clinical translation. could guide selection approach, dosage form, administration route Moreover, we discuss several promising attracting increasing attention worldwide.

Language: Английский

Citations

19

Functionalized Metal Nanoparticles in Cancer Therapy DOI Creative Commons
Paola Trinidad Villalobos‐Gutiérrez, José Luis Muñoz‐Carrillo, Cuauhtémoc Sandoval‐Salazar

et al.

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(7), P. 1932 - 1932

Published: July 11, 2023

Currently, there are many studies on the application of nanotechnology in therapy. Metallic nanoparticles promising nanomaterials cancer therapy; however, functionalization these with biomolecules has become relevant as their effect cells is considerably increased by photothermal and photodynamic therapies, drug nanocarriers, specificity antibodies, resulting new therapies that more specific against different types cancer. This review describes functionalized palladium, gold, silver platinum treatment cancer, themselves show an anticancer effect. further enhanced when NPs either DNA, RNA, peptides, proteins, or folic acid other molecules. These can penetrate cell accumulate tumor tissue, a cytotoxic through generation ROS, induction apoptosis, cycle arrest, DNA fragmentation, NP-based therapy strategy be used synergistically chemotherapy radiotherapy to achieve effective reduce side effects.

Language: Английский

Citations

25

The emerging role of miRNAs in Merkel cell carcinoma pathogenesis: Signaling pathway crosstalk DOI

Nehal I. Rizk,

Heba M. Midan,

Gouda K. Helal

et al.

Pathology - Research and Practice, Journal Year: 2023, Volume and Issue: 249, P. 154771 - 154771

Published: Aug. 19, 2023

Language: Английский

Citations

24

At the crossroad of nanotechnology and cancer cell membrane coating: Expanding horizons with engineered nanoplatforms for advanced cancer therapy harnessing homologous tumor targeting DOI
Huachun Pan, Shumin Yang, Lun Gao

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 506, P. 215712 - 215712

Published: Feb. 15, 2024

Language: Английский

Citations

16

Lipid-based nanosystems: the next generation of cancer immune therapy DOI Creative Commons
Ziyun Cheng, Seth‐Frerich Fobian, Elena Gurrieri

et al.

Journal of Hematology & Oncology, Journal Year: 2024, Volume and Issue: 17(1)

Published: July 19, 2024

Abstract Immunotherapy has become an important part of the oncotherapy arsenal. Its applicability in various cancer types is impressive, as well its use endogenous mechanisms to achieve desired ends. However, off-target or on-target-off-tumor toxicity, limited activity, lack control combination treatments and, especially for solid tumors, low local accumulation, have collectively clinical thereof. These limitations are partially alleviated by delivery systems. Lipid-based nanoparticles (NPs) emerged revolutionary carriers due favorable physicochemical characteristics, with specific applications and strengths particularly useful immunotherapeutic agent delivery. The aim this review highlight challenges faced immunotherapy how lipid-based NPs been, may be further utilized address such challenges. We discuss recent fundamental a range areas provide detailed discussion main obstacles immune checkpoint inhibition therapies, adoptive cellular cytokine therapies. nanosystems could these through either delivery, direct modulation system, targeting immunosuppressive tumor microenvironment. explore advanced emerging liposomal lipid nanoparticle (LNP) systems nucleic acid intrinsic extrinsic stimulus-responsive formulations, biomimetic immunotherapy. Finally, we key relating NP immunotherapies, suggesting future research directions near term realize potential innovative nanosystems, they crucial steppingstone towards necessary enhancement efficacy Graphical abstract

Language: Английский

Citations

14

Lipid nanoparticles for enhancing oral bioavailability DOI

Anushareddy Gangavarapu,

Lillian V. Tapia-Lopez,

Barnali Sarkar

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: 16(39), P. 18319 - 18338

Published: Jan. 1, 2024

In recent studies, lipid nanoparticles have attracted attention as drug delivery systems owing to their preeminent potential in achieving the desired bioavailability of biopharmaceutics (BCS) class II and IV drugs. The current debate concerns these poorly absorbed drugs with simultaneous oral degradation. Lipid nanoparticles, including solid (SLN) nanostructured carriers (NLC), are lipid-based carrier that can effectively encapsulate both lipophilic hydrophilic drugs, offering versatile systems. unique properties lipids (biodegradability biocompatibility) transportation pathways enhance biological availability These particles increase gastrointestinal absorption solubilization minimally bioavailable

Language: Английский

Citations

13

Nanoparticles for efficient drug delivery and drug resistance in glioma: New perspectives DOI
Jiyuan Liu, Fan Yang, Jinqu Hu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2024, Volume and Issue: 30(5)

Published: May 1, 2024

Abstract Gliomas are the most common primary tumors of central nervous system, with glioblastoma multiforme (GBM) having highest incidence, and their therapeutic efficacy depends primarily on extent surgical resection postoperative chemotherapy. The role intracranial blood–brain barrier occurrence drug‐resistant gene O6‐methylguanine‐DNA methyltransferase have greatly limited chemotherapeutic agents in patients GBM made it difficult to achieve expected clinical response. In recent years, rapid development nanotechnology has brought new hope for treatment tumors. Nanoparticles (NPs) shown great potential tumor therapy due unique properties such as light, heat, electromagnetic effects, passive targeting. Furthermore, NPs can effectively load drugs, significantly reduce side effects improve efficacy, showing chemotherapy glioma. this article, we reviewed mechanisms glioma drug resistance, physicochemical NPs, advances resistance. We aimed provide perspectives

Language: Английский

Citations

12