Human Vaccines & Immunotherapeutics,
Journal Year:
2023,
Volume and Issue:
19(3)
Published: Oct. 31, 2023
For
decades,
immunotherapies
have
offered
hope
for
patients
with
advanced
cancer.
However,
they
show
distinct
benefits
and
limited
clinical
effects.
Tumor
vaccines
the
potential
to
prime
tumor-antigen-specific
T
cells
induce
broad
subsets
of
immune
responses,
ultimately
eradicating
tumor
cells.
Here,
we
classify
by
their
anti-tumor
mechanisms,
which
include
boosting
system,
overcoming
immunosuppression,
modulating
angiogenesis.
We
focus
on
multidimensional
vaccine
strategies
using
combinations
two
or
three
above
as
these
are
superior
single-dimensional
treatments.
This
review
offers
a
perspective
future
role
therapies
in
cancer
treatment.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Aug. 12, 2024
Cancer
remains
a
significant
risk
to
human
health.
Nanomedicine
is
new
multidisciplinary
field
that
garnering
lot
of
interest
and
investigation.
shows
great
potential
for
cancer
diagnosis
treatment.
Specifically
engineered
nanoparticles
can
be
employed
as
contrast
agents
in
diagnostics
enable
high
sensitivity
high-resolution
tumor
detection
by
imaging
examinations.
Novel
approaches
labeling
are
also
made
possible
the
use
nanoprobes
nanobiosensors.
The
achievement
targeted
medication
delivery
therapy
accomplished
through
rational
design
manufacture
nanodrug
carriers.
Nanoparticles
have
capability
effectively
transport
medications
or
gene
fragments
tissues
via
passive
active
targeting
processes,
thus
enhancing
treatment
outcomes
while
minimizing
harm
healthy
tissues.
Simultaneously,
context
radiation
sensitization
photothermal
enhance
therapeutic
efficacy
malignant
tumors.
This
review
presents
literature
overview
summary
how
nanotechnology
used
According
oncological
diseases
originating
from
different
systems
body
combining
pathophysiological
features
cancers
at
sites,
we
most
recent
developments
applications.
Finally,
briefly
discuss
prospects
challenges
cancer.
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: April 10, 2024
Cancer
is
a
severe
disease
that
results
in
death
all
countries
of
the
world.
A
nano-based
drug
delivery
approach
best
alternative,
directly
targeting
cancer
tumor
cells
with
improved
cellular
uptake.
Different
types
nanoparticle-based
carriers
are
advanced
for
treatment
cancer,
and
to
increase
therapeutic
effectiveness
safety
therapy,
many
substances
have
been
looked
into
as
carriers.
Lipid-based
nanoparticles
(LBNPs)
significantly
attracted
interest
recently.
These
natural
biomolecules
alternate
other
polymers
frequently
recycled
medicine
due
their
amphipathic
properties.
Lipid
typically
provide
variety
benefits,
including
biocompatibility
biodegradability.
This
review
covers
different
classes
LBNPs,
characterization
synthesis
technologies.
discusses
most
significant
advancements
lipid
nanoparticle
technology
use
administration.
Moreover,
also
emphasized
applications
used
types.
Small,
Journal Year:
2024,
Volume and Issue:
20(26)
Published: Jan. 12, 2024
Abstract
Although
bioactive
compounds
(BCs)
have
many
important
functions,
their
applications
are
greatly
limited
due
to
own
defects.
The
development
of
nanocarriers
(NCs)
technology
has
gradually
overcome
the
defects
BCs.
NCs
equally
as
BCs
some
extent.
Self‐assembly
(SA)
methods
build
advantages
than
chemical
methods,
and
SA
significant
impact
on
structure
function
NCs.
However,
relationship
among
mechanism,
structure,
not
been
given
enough
attention.
Therefore,
from
perspective
bottom‐up
building
concept
SA‐structure‐function
is
emphasized
promote
SA‐based
First,
conditions
forces
for
occurring
introduced,
then
basis
molecular
mechanism
protein,
polysaccharide,
lipid
summarized.
Then,
varieties
structures
formed
based
introduced
in
detail.
Finally,
facing
how
be
well
solved
by
also
elaborated.
This
review
attempts
describe
great
significance
constructing
artificial
deliver
aspects
SA‐structure‐function,
so
wide
application
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4683 - 4716
Published: Sept. 2, 2024
About
40%
of
approved
drugs
and
nearly
90%
drug
candidates
are
poorly
water-soluble
drugs.
Low
solubility
reduces
the
drugability.
Effectively
improving
bioavailability
is
a
critical
issue
that
needs
to
be
urgently
addressed
in
development
application.
This
review
briefly
introduces
conventional
solubilization
techniques
such
as
solubilizers,
hydrotropes,
cosolvents,
prodrugs,
salt
modification,
micronization,
cyclodextrin
inclusion,
solid
dispersions,
details
crystallization
strategies,
ionic
liquids,
polymer-based,
lipid-based,
inorganic-based
carriers
bioavailability.
Some
most
commonly
used
carrier
materials
for
presented.
Several
using
summarized.
Furthermore,
this
summarizes
mechanism
each
technique,
reviews
latest
research
advances
challenges,
evaluates
potential
clinical
translation.
could
guide
selection
approach,
dosage
form,
administration
route
Moreover,
we
discuss
several
promising
attracting
increasing
attention
worldwide.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(7), P. 1932 - 1932
Published: July 11, 2023
Currently,
there
are
many
studies
on
the
application
of
nanotechnology
in
therapy.
Metallic
nanoparticles
promising
nanomaterials
cancer
therapy;
however,
functionalization
these
with
biomolecules
has
become
relevant
as
their
effect
cells
is
considerably
increased
by
photothermal
and
photodynamic
therapies,
drug
nanocarriers,
specificity
antibodies,
resulting
new
therapies
that
more
specific
against
different
types
cancer.
This
review
describes
functionalized
palladium,
gold,
silver
platinum
treatment
cancer,
themselves
show
an
anticancer
effect.
further
enhanced
when
NPs
either
DNA,
RNA,
peptides,
proteins,
or
folic
acid
other
molecules.
These
can
penetrate
cell
accumulate
tumor
tissue,
a
cytotoxic
through
generation
ROS,
induction
apoptosis,
cycle
arrest,
DNA
fragmentation,
NP-based
therapy
strategy
be
used
synergistically
chemotherapy
radiotherapy
to
achieve
effective
reduce
side
effects.
Journal of Hematology & Oncology,
Journal Year:
2024,
Volume and Issue:
17(1)
Published: July 19, 2024
Abstract
Immunotherapy
has
become
an
important
part
of
the
oncotherapy
arsenal.
Its
applicability
in
various
cancer
types
is
impressive,
as
well
its
use
endogenous
mechanisms
to
achieve
desired
ends.
However,
off-target
or
on-target-off-tumor
toxicity,
limited
activity,
lack
control
combination
treatments
and,
especially
for
solid
tumors,
low
local
accumulation,
have
collectively
clinical
thereof.
These
limitations
are
partially
alleviated
by
delivery
systems.
Lipid-based
nanoparticles
(NPs)
emerged
revolutionary
carriers
due
favorable
physicochemical
characteristics,
with
specific
applications
and
strengths
particularly
useful
immunotherapeutic
agent
delivery.
The
aim
this
review
highlight
challenges
faced
immunotherapy
how
lipid-based
NPs
been,
may
be
further
utilized
address
such
challenges.
We
discuss
recent
fundamental
a
range
areas
provide
detailed
discussion
main
obstacles
immune
checkpoint
inhibition
therapies,
adoptive
cellular
cytokine
therapies.
nanosystems
could
these
through
either
delivery,
direct
modulation
system,
targeting
immunosuppressive
tumor
microenvironment.
explore
advanced
emerging
liposomal
lipid
nanoparticle
(LNP)
systems
nucleic
acid
intrinsic
extrinsic
stimulus-responsive
formulations,
biomimetic
immunotherapy.
Finally,
we
key
relating
NP
immunotherapies,
suggesting
future
research
directions
near
term
realize
potential
innovative
nanosystems,
they
crucial
steppingstone
towards
necessary
enhancement
efficacy
Graphical
abstract
Nanoscale,
Journal Year:
2024,
Volume and Issue:
16(39), P. 18319 - 18338
Published: Jan. 1, 2024
In
recent
studies,
lipid
nanoparticles
have
attracted
attention
as
drug
delivery
systems
owing
to
their
preeminent
potential
in
achieving
the
desired
bioavailability
of
biopharmaceutics
(BCS)
class
II
and
IV
drugs.
The
current
debate
concerns
these
poorly
absorbed
drugs
with
simultaneous
oral
degradation.
Lipid
nanoparticles,
including
solid
(SLN)
nanostructured
carriers
(NLC),
are
lipid-based
carrier
that
can
effectively
encapsulate
both
lipophilic
hydrophilic
drugs,
offering
versatile
systems.
unique
properties
lipids
(biodegradability
biocompatibility)
transportation
pathways
enhance
biological
availability
These
particles
increase
gastrointestinal
absorption
solubilization
minimally
bioavailable
Abstract
Gliomas
are
the
most
common
primary
tumors
of
central
nervous
system,
with
glioblastoma
multiforme
(GBM)
having
highest
incidence,
and
their
therapeutic
efficacy
depends
primarily
on
extent
surgical
resection
postoperative
chemotherapy.
The
role
intracranial
blood–brain
barrier
occurrence
drug‐resistant
gene
O6‐methylguanine‐DNA
methyltransferase
have
greatly
limited
chemotherapeutic
agents
in
patients
GBM
made
it
difficult
to
achieve
expected
clinical
response.
In
recent
years,
rapid
development
nanotechnology
has
brought
new
hope
for
treatment
tumors.
Nanoparticles
(NPs)
shown
great
potential
tumor
therapy
due
unique
properties
such
as
light,
heat,
electromagnetic
effects,
passive
targeting.
Furthermore,
NPs
can
effectively
load
drugs,
significantly
reduce
side
effects
improve
efficacy,
showing
chemotherapy
glioma.
this
article,
we
reviewed
mechanisms
glioma
drug
resistance,
physicochemical
NPs,
advances
resistance.
We
aimed
provide
perspectives
