Transcutaneous Auricular Vagus Nerve Stimulation for Chronic Insomnia Disorder

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(12), P. e2451217 - e2451217

Published: Dec. 16, 2024

IMPORTANCE Evidence from randomized clinical trials of transcutaneous auricular vagus nerve stimulation (taVNS) for chronic insomnia disorder is lacking. OBJECTIVE To evaluate the efficacy and safety taVNS compared with sham taVNS. DESIGN, SETTING, PARTICIPANTS This trial was conducted October 2021 to December 2022 at a single center in Beijing, China. Patients Pittsburgh Sleep Quality Index (PSQI) least 8 were enrolled. Statistical analysis performed June September 2023. INTERVENTIONS allocated active group or 1:1 ratio. Both groups received 30 minutes each time, twice day, 5 consecutive days week, an 8-week treatment 12-week follow-up. MAIN OUTCOMES AND MEASURES The primary end point mean change baseline through week PSQI scores. Minimal clinically important difference 2.5 points. Secondary outcomes included mental health, sleepiness, fatigue. Safety also evaluated. RESULTS A total 72 participants either (36 participants; [SD] age, 45.2 [14.5] years; 27 [75.0%] female) 44.6 [13.9] 31 [86.1%] female); 68 completed intervention. least-square changes −8.2 (95% CI, −9.3 −7.0) points −3.9 −5.1 −2.7) group. experienced statistically significant improvements before after However, showed meaningful 4.2-point greater reduction −5.9 −2.6 points; P < .001; Cohen d effect size, 1.2) (minimal = points). outcomes, including health fatigue, similar favorable results. sustained throughout 20-week study period. CONCLUSIONS RELEVANCE In this trial, significantly reduced severity. Clinically enhancements scores observed stimulation, benefits over Future multicenter large sample sizes are needed validate its effectiveness across diverse populations. Trial Registration Chinese Clinical Registry: ChiCTR2100051319

Language: Английский

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Transcutaneous Auricular Vagus Nerve Stimulation Enhances Emotional Processing and Long‐Term Recognition Memory: Electrophysiological Evidence Across Two Studies

Psychophysiology, Journal Year: 2025, Volume and Issue: 62(3)

Published: March 1, 2025

ABSTRACT Recently, we found that continuous transcutaneous auricular vagus nerve stimulation (taVNS) facilitates the encoding and later recollection of emotionally relevant information, as indicated by differences in late positive potential (LPP), memory performance, ERP Old/New effect. Here, aimed to conceptually replicate extend these findings investigating effects different time‐dependent taVNS protocols. In Study 1, an identical paradigm our previous study was employed with interval (30‐s on/off). Participants viewed unpleasant neutral scenes on two consecutive days while receiving or sham completed a recognition test 1 week later. Replicating results, images encoded under taVNS, compared stimulation, elicited larger amplitudes earlier window LPP during encoding, well more pronounced differences. However, no performance were found. 2, followed up synchronizing cycle image presentation determine for off cycles. We could enhancing brain potentials (early differences) improved recollection‐based both images, independently cycle. Overall, results suggest increases electrophysiological correlates emotional retrieval time‐independent manner, substantiating nerve's role processing formation, opening new venues improving mnemonic processes clinical non‐clinical populations.

Language: Английский

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Effects of off-line auricular transcutaneous vagus nerve stimulation (taVNS) on a short-term memory task: a pilot study

Frontiers in Aging Neuroscience, Journal Year: 2025, Volume and Issue: 17

Published: April 28, 2025

One of the commonly used indices short-term memory (STM) is digit span task. Prior studies have proposed pupil dilation as a measure task engagement and promising biomarker vagal activation. Transcutaneous auricular vagus nerve stimulation (taVNS) novel non-invasive brain technique which might be to improve cognition modulate size through its effects on noradrenergic release in locus coeruleus. No previous study has investigated off-line taVNS With this single-blind, sham-controlled, crossover design trial, we aimed assess whether was able score, well pupillary response cognitive load sample 18 elderly Japanese volunteers with no self-reported impairments. Subjects were randomized receive either real or sham during while recording size, then switched over other treatment group. We found that significantly reduced mean number errors performed at length 7, 8, 9 (-0.83, -0.90, -0.39, respectively compared pre-stimulation values, -0.71, -1.08, -0.79, respectively, stimulation). Additionally, slightly but increased all lengths encoding period task, larger for 7-10 pre-stimulation, 5-10 sham. effect recall period. Our results suggest selectively performance phase Although further are needed better clarify optimal parameters, findings from could support use safe neuromodulation function.

Language: Английский

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Closed-Loop Transcutaneous Auricular Vagal Nerve Stimulation: Current Situation and Future Possibilities

Frontiers in Human Neuroscience, Journal Year: 2022, Volume and Issue: 15

Published: Jan. 4, 2022

Closed-loop (CL) transcutaneous auricular vagal nerve stimulation (taVNS) was officially proposed in 2020. This work firstly reviewed two existing CL-taVNS forms: motor-activated vagus (MAAVNS) and respiratory-gated afferent (RAVANS), then three future systems: electroencephalography (EEG)-gated CL-taVNS, electrocardiography (ECG)-gated subcutaneous humoral signals (SHS)-gated CL-taVNS. We also highlighted the mechanisms, targets, technical issues, patterns of By reviewing, proposing, highlighting, this might draw a preliminary blueprint for development

Language: Английский

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The Locus Coeruleus: Where Cognitive and Emotional Processing Meet the Eye

Springer eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 3 - 75

Published: Jan. 1, 2024

Language: Английский

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Does transcutaneous vagus nerve stimulation alter pupil dilation? A living Bayesian meta-analysis

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Transcutaneous vagus nerve stimulation (tVNS) has emerged as a promising technique to modulate autonomic functions, and pupil dilation been recognized biomarker for tVNS-induced monoaminergic release. Nevertheless, studies on the effectiveness of various tVNS protocols have produced heterogeneous results dilatation date. Here, we synthesize existing evidence compare conventional continuous pulsed using Bayesian meta-analysis. To maintain living version, developed Shiny App with possibility incorporate newly published in future. Based systematic review, included 18 (N = 771) applying either or protocols. Across studies, found anecdotal alternative hypothesis that increases size ( g 0.14, 95% CI [0.001, 0.29], BF01 2.5). Separating according vs. revealed were driven by taVNS (strong hypothesis: 0.34, [0.15, 0.53], BF10 14.15) while provided strong null 0.01, [-0.15, 0.16], BF01= 20.7). In conclusion, our meta-analysis highlights differential effects dilation. These findings underscore relevance optimizing its use specific applications may require modulation tonic phasic responses.

Language: Английский

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Impact of Stimulation Duration in taVNS—Exploring Multiple Physiological and Cognitive Outcomes

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(9), P. 875 - 875

Published: Aug. 29, 2024

Transcutaneous auricular vagus nerve stimulation (taVNS) is a non-invasive neuromodulation technique that modulates the noradrenergic activity of locus coeruleus (LC). Yet, there still uncertainty about most effective and reliable outcome parameters. In double blind, sham-controlled study including sample healthy young individuals (N = 29), we compared shorter (3.4 s) longer (30 duration investigated effects taVNS (real vs. sham) on saliva samples (alpha amylase cortisol concentration), pupil (pupillary light reflex size at rest) EEG data theta rest, ERPs for No-Go signals), cognitive tasks (Go/No-Go Stop Signal Tasks). Salivary alpha concentration was significantly increased in real as to sham 30 s condition. 3.4 condition, found prolonged reaction times error rates Go/No-Go task maximum acceleration pupillary reflex. For other outcomes, no significant differences were found. Our results show increases salivary alpha-amylase, which expected from functional properties LC. The finding response short not cannot be explained by an increase LC activity. We also discuss difficulties assessing expression taVNS-mediated changes.

Language: Английский

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Can transcutaneous auricular vagus nerve stimulation mitigate vigilance loss? Examining the effects of stimulation at individualized versus constant current intensity

Psychophysiology, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 21, 2024

Abstract According to the arousal model of vigilance, locus coeruleus‐norepinephrine (LC‐NE) system modulates sustained attention over long periods by regulating physiological arousal. Recent research has proposed that transcutaneous auricular vagus nerve stimulation (taVNS) indirect markers LC‐NE activity, although its effects on vigilance have not yet been examined. Aiming develop a safe and noninvasive procedure prevent failures in prolonged tasks, present study examined whether taVNS can mitigate loss while modulating activity. Following preregistered protocol ( https://osf.io/tu2xy/ ), 50 participants completed three repeated sessions randomized order, which either active at individualized intensity set participant, 0.5 mA for all participants, or sham taVNS, was delivered performing an attentional task (i.e., ANTI‐Vea). Changes salivary alpha‐amylase cortisol concentrations were measured as Self‐reports feelings associated with guessing rate active/sham conditions supported efficacy single‐blind procedure. Contrary our predictions, observed decrement modulated taVNS. Pairwise comparisons showed mitigation reduction across time. Interestingly, Spearman's correlational analyses some interindividual LC‐NE, evidenced positive associations between changes but We highlight relevance replicating extending outcomes, investigating further parameters other

Language: Английский

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300 Hz transcutaneous auricular vagus nerve stimulation (taVNS) impacts pupil size nonlinearly as a function of intensity

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 25, 2024

Abstract Transcutaneous auricular vagus nerve stimulation (taVNS) is a neuromodulatory technique that may have numerous potential health and human performance benefits. However, optimal parameters for maximizing taVNS efficacy are unknown. Progress impeded by disagreement on the identification of biomarker reliably indexes activation systems targeted taVNS, including locus coeruleus-norepinephrine (LC-NE) system. Pupil size varies with LC-NE activity one has shown inconsistent sensitivity to in prior studies. The present study examined relationship between pupil using promising behavioral effects studies but received comparatively little attention. Participants 30-second trains 50 μs pulses delivered below perceptual threshold at 300 Hz left external acoustic meatus (EAM) while was recorded during pupillary light reflex task. Analysis generalized additive mixed modelling (GAMM) revealed nonlinear intensity diameter. Active increased participants who 2 approximately 4.8 mA, not higher (up 8.1 mA). In addition, persisted subsequent blocks, mitigating decreases over course These findings suggest activates system when applied EAM, its be counteracted intensities.

Language: Английский

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Pupillary response to percutaneous auricular vagus nerve stimulation in alcohol withdrawal syndrome: A pilot trial

Alcohol, Journal Year: 2023, Volume and Issue: 114, P. 61 - 68

Published: Sept. 2, 2023

Autonomic symptoms in alcohol withdrawal syndrome (AWS) are associated with a sympathetic-driven imbalance of the autonomic nervous system. To restore balance AWS, novel neuromodulatory approaches could be beneficial. We conducted pilot trial percutaneous auricular vagus nerve stimulation (pVNS) AWS and hypothesized that pVNS will enhance parasympathetic tone represented by reduction pupillary dilation parasympatholytic pharmacological challenge.

Language: Английский

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