Melatonin may decrease risk for and aid treatment of COVID-19 and other RNA viral infections DOI Creative Commons
James J. DiNicolantonio, Mark F. McCarty,

Jorge Barroso-Aranda

et al.

Open Heart, Journal Year: 2021, Volume and Issue: 8(1), P. e001568 - e001568

Published: March 1, 2021

A recent retrospective study has provided evidence that COVID-19 infection may be notably less common in those using supplemental melatonin. It is suggested this phenomenon reflect the fact that, via induction of silent information regulator 1 (Sirt1), melatonin can upregulate K63 polyubiquitination mitochondrial antiviral-signalling protein, thereby boosting virally mediated type interferons. Moreover, Sirt1 enhance antiviral efficacy interferons by preventing hyperacetylation high mobility group box (HMGB1), enabling its retention nucleus, where it promotes transcription interferon-inducible genes. This nuclear HMGB1 also a mediator anti-inflammatory effect therapy COVID-19-complementing melatonin's suppression factor kappa B activity and upregulation erythroid 2-related 2. If these speculations are correct, nutraceutical regimen including vitamin D, zinc supplementation have general utility for prevention treatment RNA virus infections, such as influenza.

Language: Английский

Current State of Evidence: Influence of Nutritional and Nutrigenetic Factors on Immunity in the COVID-19 Pandemic Framework DOI Open Access
Sebastià Galmés, Francisca Serra, Andreu Palou

et al.

Nutrients, Journal Year: 2020, Volume and Issue: 12(9), P. 2738 - 2738

Published: Sept. 8, 2020

The pandemic caused by the new coronavirus has shock waves in many countries, producing a global health crisis worldwide. Lack of knowledge biological mechanisms viruses, plus absence effective treatments against disease (COVID-19) and/or vaccines have pulled factors that can compromise proper functioning immune system to fight infectious diseases into spotlight. optimal status specific nutrients is considered crucial keeping components within their normal activity, helping avoid and overcome infections. Specifically, European Food Safety Authority (EFSA) evaluated deems six vitamins (D, A, C, Folate, B

Language: Английский

Citations

172
COVID-19 Impact on Public Health, Environment, Human Psychology, Global Socioeconomy, and Education DOI Creative Commons
Youssef Miyah, Mohammed Benjellοun,

Sanae Lairini

et al.

The Scientific World JOURNAL, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 8

Published: Jan. 11, 2022

The end of the year 2019 was marked by introduction a third highly pathogenic coronavirus, after SARS-CoV (2003) and MERS-CoV (2012), in human population which officially declared global pandemic World Health Organization (WHO) on March 11, 2020. Indeed, COVID-19 (Coronavirus Disease 19) has evolved at an unprecedented rate: its emergence Wuhan, capital province Hubei People's Republic China, December 2019, total number confirmed cases did not cease growing very quickly world. In this manuscript, we have provided overview impact health, proposed different nutrients suitable for infected patients to boost their immune systems. On other hand, described advantages disadvantages environment including quality water, air, waste management, energy consumption, as well psychology, educational system, economy. addition, tried come up with some solutions counter negative repercussions pandemic.

Language: Английский

Citations

156
Antiaging Strategies and Remedies: A Landscape of Research Progress and Promise DOI Creative Commons

Rumiana Tenchov,

Janet M. Sasso, Xinmei Wang

et al.

ACS Chemical Neuroscience, Journal Year: 2024, Volume and Issue: 15(3), P. 408 - 446

Published: Jan. 12, 2024

Aging is typified by a gradual loss of physiological fitness and accumulation cellular damage, leading to deteriorated functions enhanced vulnerability diseases. Antiaging research has long history throughout civilization, with many efforts put forth understand prevent the effects aging. Multiple strategies aiming promote healthy aging extend lifespan have been developed including lifestyle adjustments, medical treatments, social programs. A multitude antiaging medicines remedies also explored. Here, we use data from CAS Content Collection analyze publication landscape recent related treatments. We review advances delineate trends in headway knowledge practice across time, geography, development pipelines. further assess state-of-the-art approaches explore their correlations age-related The drugs outlined Well-recognized novel, currently evaluated agents summarized. Finally, clinical applications products objective this summarize current on preventive treatment field aging, outline challenges evaluate growth opportunities, order solve problems that remain.

Language: Английский

Citations

12
Zinc nutrition and dietary zinc supplements DOI

Maoping Duan,

Li Tian, Bo Liu

et al.

Critical Reviews in Food Science and Nutrition, Journal Year: 2021, Volume and Issue: 63(9), P. 1277 - 1292

Published: Aug. 12, 2021

As the second most abundant trace element in human body, zinc nutrition is constantly a hot topic. More than one-third population suffering deficiency, which results various types of diseases or nutritional deficiencies. Traditional ways supplementation seem with low absorption rates and significant side effects. Zinc supplements dietary components are easily accessible improve utilization rate significantly. Also, mechanisms maintaining homeostasis broad interest. The present review focuses on health inductive methods. Mainly elaborate different relating to disorder, highlighting impact immune system recent COVID-19. Then raise food-derived zinc-binding compounds, including protein, peptide, polysaccharide, polyphenol, also analyze their possibilities serve as complementary. Finally, illustrate way maintain corresponding mechanisms. provides data information for matrix.

Language: Английский

Citations

55
Food Security during the Pandemic and the Importance of the Bioeconomy in the New Era DOI Open Access
Anca Corina Fărcaș, Charis M. Galanakis, Carmen Socaciu

et al.

Sustainability, Journal Year: 2020, Volume and Issue: 13(1), P. 150 - 150

Published: Dec. 25, 2020

One of the biggest challenges in managing food sector during a pandemic crisis is sustaining robust security system and adopting right strategies correlating consumers’ needs requirements with those safety, producers, distribution chain, economic environment, waste management. The restrictions on people’s global movement, commodities, services measures taken to reduce spread COVID-19 have disrupted environments around world forced us collectively redesign optimize our systems using existing resources from more sustainable perspective. This paper offers an overview implications for supply chain discusses several potential tackling short- long-term adverse effects resulting pandemic.

Language: Английский

Citations

54
COVID-19 in the elderly people and advances in vaccination approaches DOI Creative Commons
Kuldeep Dhama, Shailesh Kumar Patel,

Senthilkumar Natesan

et al.

Human Vaccines & Immunotherapeutics, Journal Year: 2020, Volume and Issue: 16(12), P. 2938 - 2943

Published: Dec. 1, 2020

The rapid worldwide spread of the COVID-19 pandemic, caused by newly emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has resulted in tens millions infections and over one million deaths. SARS-CoV-2 infection affects all age groups; however, those 60 years old are affected more severely. Moreover, pre-existing co-morbidities result higher COVID-19-associated mortality geriatric population. This article highlights associated risk factors older people progress developing vaccines, especially for efficient vaccination There is also a summary immunomodulatory immunotherapeutic approaches to ameliorate outcome individuals.

Language: Английский

Citations

53
The effects of some essential and toxic metals/metalloids in COVID-19: A review DOI Open Access
José L. Domingo, Montse Marquès

Food and Chemical Toxicology, Journal Year: 2021, Volume and Issue: 152, P. 112161 - 112161

Published: March 29, 2021

Language: Английский

Citations

42
Dietary Supplements and Natural Products: An Update on Their Clinical Effectiveness and Molecular Mechanisms of Action During Accelerated Biological Aging DOI Creative Commons
Ye Chen, Sherif Hamidu,

Xintong Yang

et al.

Frontiers in Genetics, Journal Year: 2022, Volume and Issue: 13

Published: April 28, 2022

Graphical Abstract

Language: Английский

Citations

38
The Role of Diet and Supplementation of Natural Products in COVID-19 Prevention DOI Creative Commons
Amin Gasmi, Salvatore Chirumbolo, Massimiliano Peana

et al.

Biological Trace Element Research, Journal Year: 2021, Volume and Issue: 200(1), P. 27 - 30

Published: Feb. 25, 2021

Language: Английский

Citations

34
Post-COVID-19 Fungal Infection in the Aged Population DOI Creative Commons
Vivek P. Chavda, Toshika Mishra, Sathvika Kamaraj

et al.

Vaccines, Journal Year: 2023, Volume and Issue: 11(3), P. 555 - 555

Published: Feb. 27, 2023

Coronavirus disease 2019 (COVID-19) infection is currently a great cause of concern for the healthcare sector around globe. SARS-CoV-2 an RNA virus that causes serious associated with numerous adverse effects and multiple complications different organs systems during its pathogenic cycle in humans. Individuals affected by COVID-19, especially elderly populations immunocompromised people, are greatly vulnerable to opportunistic fungal pathogens. Aspergillosis, invasive candidiasis, mucormycosis widespread coinfections COVID-19 patients. Other infections rare but exhibiting increased incidence current scenario include caused Pneumocystis jirovecii, Histoplasma sp., Cryptococcus etc. By producing virulent spores, these pathogens increase severity morbidity fatality rates patients globally. These generally occur recovering from infection, resulting rehospitalization. Older individuals at higher risk developing infections. This review focuses on understanding prevalent patients, people. We have also highlighted important preventive methods, diagnostic approaches, prophylactic measures

Language: Английский

Citations

15