LitCovid: an open database of COVID-19 literature

Nucleic Acids Research, Journal Year: 2020, Volume and Issue: 49(D1), P. D1534 - D1540

Published: Oct. 8, 2020

Since the outbreak of current pandemic in 2020, there has been a rapid growth published articles on COVID-19 and SARS-CoV-2, with about 10,000 new added each month. This is causing an increasingly serious information overload, making it difficult for scientists, healthcare professionals general public to remain up date latest SARS-CoV-2 research. Hence, we developed LitCovid (https://www.ncbi.nlm.nih.gov/research/coronavirus/), curated literature hub, track up-to-date scientific PubMed. updated daily newly identified relevant organized into categories. To support manual curation, advanced machine-learning deep-learning algorithms have developed, evaluated integrated curation workflow. best our knowledge, first-of-its-kind COVID-19-specific resource, all its collected data freely available. release, widely used, millions accesses by users worldwide various needs, such as evidence synthesis, drug discovery text mining, among others.

Language: Английский

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Patterns of Change in Dietary Habits and Physical Activity during Lockdown in Spain Due to the COVID-19 Pandemic

Nutrients, Journal Year: 2021, Volume and Issue: 13(2), P. 300 - 300

Published: Jan. 21, 2021

Lockdown due to COVID-19 influenced food habits and lifestyles with potential negative health impact. This study aims identify patterns of change in eating physical activity during lockdown Spain associations sociodemographic factors usual habits.

Language: Английский

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Nutrition in the Actual COVID-19 Pandemic. A Narrative Review

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 1924 - 1924

Published: June 3, 2021

The pandemic of Coronavirus Disease 2019 (COVID-19) has shocked world health authorities generating a global crisis. present study discusses the main finding in nutrition sciences associated with COVID-19 literature. We conducted consensus critical review using primary sources, scientific articles, and secondary bibliographic indexes, databases, web pages. method was narrative literature available regarding interventions nutrition-related factors during pandemic. search engines used research were PubMed, SciELO, Google Scholar. found how lockdown promoted unhealthy dietary changes increases body weight population, showing obesity low physical activity levels as increased risk affection physiopathology. In addition, hospitalized patients presented malnutrition deficiencies vitamin C, D, B12 selenium, iron, omega-3, medium long-chain fatty acids highlighting potential effect C D interventions. Further investigations are needed to show complete role implications both prevention treatment COVID-19.

Language: Английский

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Malnutrition: Percentage and Association with Prognosis in Patients Hospitalized for Coronavirus Disease 2019

Nutrients, Journal Year: 2020, Volume and Issue: 12(12), P. 3679 - 3679

Published: Nov. 28, 2020

Previous studies have found a correlation between malnutrition and prognosis in respiratory infections. Our objectives were to determine (i) the percentage of malnutrition, (ii) its patients admitted for coronavirus disease 2019 (COVID-19). In this monocentric retrospective study, we consecutively included all adult presenting with acute COVID-19 9 April 29 May 2020. Malnutrition was diagnosed on low body mass index (BMI) weight loss ≥ 5% previous month and/or 10% six months. The Nutritional Risk Index (NRI) defined nutritional risk. Severe as need nasal oxygen 6 L/min. We enrolled 108 (64 men, 62 ± 16 years, BMI 28.8 6.2 kg/m2), including 34 (31.5%) severe COVID-19. 42 (38.9%) patients, moderate or risk 83 (84.7%) patients. not associated severity. (p < 0.01; p 0.01 after adjustment C reactive protein), lower plasma proteins, albumin, prealbumin, zinc levels 0.01). main cause inflammation. high association supports international guidelines advising regular screening support when necessary.

Language: Английский

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Food Sources of Selenium and Its Relationship with Chronic Diseases

Nutrients, Journal Year: 2021, Volume and Issue: 13(5), P. 1739 - 1739

Published: May 20, 2021

Selenium (Se) is an essential micronutrient for mammals, and its deficiency seriously threatens human health. A series of biofortification strategies have been developed to produce Se-enriched foods combating Se deficiency. Although there some inconsistent results, extensive evidence has suggested that supplementation beneficial preventing treating several chronic diseases. Understanding the association between diseases guiding clinical practice, developing effective public health policies, ultimately counteracting issues associated with The current review will discuss food sources Se, strategies, metabolism biological activities, disorders dietary reference intakes, as well relationship outcomes, especially cardiovascular disease, diabetes, inflammation, cancer, fertility. Additionally, concepts were proposed, a non-linear U-shaped dose-responsive status effects: subjects low baseline can benefit from supplementation, while in populations adequate or high may potentially increase risk In addition, at supra-nutritional levels, methylated compounds exerted more promising cancer chemo-preventive efficacy preclinical trials.

Language: Английский

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Relation of Serum Copper Status to Survival in COVID-19

Nutrients, Journal Year: 2021, Volume and Issue: 13(6), P. 1898 - 1898

Published: May 31, 2021

The trace element copper (Cu) is part of our nutrition and essentially needed for several cuproenzymes that control redox status support the immune system. In blood, ferroxidase ceruloplasmin (CP) accounts majority circulating Cu serves as transport protein. Both CP behave positive, whereas serum selenium (Se) its transporter selenoprotein P (SELENOP) negative acute phase reactants. view coronavirus disease (COVID-19) causes systemic inflammation, we hypothesized biomarkers Se are regulated inversely, in relation to severity mortality risk. Serum samples from COVID-19 patients were analysed by total reflection X-ray fluorescence was quantified a validated sandwich ELISA. two correlated positively with (R = 0.42,

Language: Английский

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Immunomodulating Effects of Fungal Beta-Glucans: From Traditional Use to Medicine

Nutrients, Journal Year: 2021, Volume and Issue: 13(4), P. 1333 - 1333

Published: April 17, 2021

The importance of a well-functioning and balanced immune system has become more apparent in recent decades. Various elements have however not yet been uncovered as shown, for example, the uncertainty on responses to COVID-19. Fungal beta-glucans are bioactive molecules with immunomodulating properties. Insights into effects function beta-glucans, which used traditional Chinese medicine centuries, advances help modern immunological biotechnological methods. However, it is still unclear area fit best: supplements or medicine? This review highlighted potential application fungal nutrition medicine, reviewing their formulation, efficacy, safety profile, effects. current status dietary glucans respect European scientific requirements health claims related defense against pathogens reviewed. Comparing evidence base putative beta-glucan published guidance documents by EFSA substantiating stimulation pathogen food products shows that could play role supporting maintaining and, thus, can be seen good health-promoting substance from food, mean this effect may also claimed if approved. In addition these developments uses beta-glucan-containing supplements, hold novel position Western concept trained immunity relatively new investigated large extent. These innovative concepts, together emerging success methods, suggest promising both perspectives, there possibilities provide an nutrition.

Language: Английский

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The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic

Journal of Inflammation Research, Journal Year: 2021, Volume and Issue: Volume 14, P. 527 - 550

Published: Feb. 1, 2021

The global pandemic from COVID-19 infection has generated significant public health concerns, both health-wise and economically. There is no specific pharmacological antiviral therapeutic option to date available for management. Also, there an urgent need discover effective medicines, prevention, control methods because of the harsh death toll this novel coronavirus infection. Acute respiratory tract infections, significantly lower pneumonia are primary cause millions deaths worldwide. role micronutrients, including trace elements, boosted human immune system was well established. Several vitamins such as vitamin A, B6, B12, C, D, E, folate; microelement zinc, iron, selenium, magnesium, copper; omega-3 fatty acids eicosapentaenoic acid docosahexaenoic plays essential physiological roles in promoting system. Furthermore, zinc indispensable a thorough enzymatic process. It also helps regulate gene-transcription DNA replication, RNA transcription, cell division, activation biological Subsequently, together with natural scavenger cells neutrophils, involved developing responsible regulating nonspecific immunity. modern food habit often promotes deficiency; such, quite few patients presented hospitals were frequently diagnosed deficient. Earlier studies documented that deficiency predisposes viral herpes simplex, common cold, hepatitis severe acute syndrome (SARS-CoV-1), immunodeficiency virus (HIV) reducing This manuscript aimed discuss various played by management

Language: Английский

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Nutrient supplementation for prevention of viral respiratory tract infections in healthy subjects: A systematic review and meta‐analysis

Allergy, Journal Year: 2021, Volume and Issue: 77(5), P. 1373 - 1388

Published: Oct. 10, 2021

It remains uncertain as to whether nutrient supplementation for the general population considered healthy could be useful in prevention of RTIs, such COVID-19. In this systematic review and meta-analysis, evidence was evaluated primary any viral respiratory tract infection (RTI) SARS-CoV-2, through nutrients with a recognized role immune function: multiple micronutrients, vitamin A, folic acid, B12, C, D, E, beta-carotene, zinc, iron long-chain polyunsaturated fatty acids. The search produced 15,163 records which 93 papers (based on 115 studies) met inclusion criteria, resulting 199,055 subjects (191,636 children 7,419 adults) from 37 countries. Sixty-three studies were included meta-analyses, performed adults separately. By stratifying meta-analysis by world regions, only Asia showed significant but heterogeneous protective effect zinc RTIs (RR 0.86, 95% CI 0.7-0.96, I2 = 79.1%, p .000). Vitamin D significantly decreased incidence RTI 0.89, 0.79-0.99, .272), particularly North America 0.82 0.68-0.97), not Europe or Oceania. Supplementation has either no at most very limited RTIs. Zinc appears Asia, whilst may protect USA Canada. 10/115 (8.7%) post-hoc analyses based stratification nutritional status performed. one study found more effective low serum compared normal levels.

Language: Английский

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Vitamin E and Metabolic Health: Relevance of Interactions with Other Micronutrients

Antioxidants, Journal Year: 2022, Volume and Issue: 11(9), P. 1785 - 1785

Published: Sept. 9, 2022

A hundred years have passed since vitamin E was identified as an essential micronutrient for mammals. Since then, many biological functions of been unraveled in both cell and animal models, including antioxidant anti-inflammatory properties, well regulatory activities on signaling gene expression. However, the bioavailability physiological considerably shown to depend lifestyle, genetic factors, individual health conditions. Another important facet that has considered less so far is endogenous interaction with other nutrients. Accumulating evidence indicates between nutrients, especially those are enriched by supplementation humans, may explain at least some discrepancies observed clinical trials. Meanwhile, increasing suggests different forms metabolites derivates also exhibit activities, which more potent mediated via pathways compared respective precursors. In this review, possible molecular mechanisms nutritional factors discussed their potential impact pathophysiological processes evaluated using published co-supplementation studies.

Language: Английский

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