UPRmt regulation and output: a stress response mediated by mitochondrial-nuclear communication

Cell Research, Journal Year: 2018, Volume and Issue: 28(3), P. 281 - 295

Published: Feb. 9, 2018

The mitochondrial network is not only required for the production of energy, essential cofactors and amino acids, but also serves as a signaling hub innate immune apoptotic pathways. Multiple mechanisms have evolved to identify combat dysfunction maintain health organism. One such pathway unfolded protein response (UPR

Language: Английский

---

One-carbon metabolism in cancer

British Journal of Cancer, Journal Year: 2017, Volume and Issue: 116(12), P. 1499 - 1504

Published: May 4, 2017

Cells require one-carbon units for nucleotide synthesis, methylation and reductive metabolism, these pathways support the high proliferative rate of cancer cells. As such, anti-folates, drugs that target have long been used in treatment cancer. Amino acids, such as serine are a major source, cells particularly susceptible to deprivation by restriction or inhibition de novo synthesis. Recent work has also begun decipher specific sub-cellular compartments important metabolism In this review we summarise historical understanding cancer, describe recent findings regarding generation usage explore possible future therapeutics could exploit dependency on metabolism.

Language: Английский

---

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

Nature reviews. Cancer, Journal Year: 2019, Volume and Issue: 19(11), P. 625 - 637

Published: Sept. 12, 2019

Language: Английский

---

An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans

Cell Metabolism, Journal Year: 2018, Volume and Issue: 27(3), P. 559 - 571.e5

Published: Feb. 15, 2018

Language: Английский

---

ESPEN micronutrient guideline

Clinical Nutrition, Journal Year: 2022, Volume and Issue: 41(6), P. 1357 - 1424

Published: Feb. 26, 2022

Language: Английский

---

NADPH homeostasis in cancer: functions, mechanisms and therapeutic implications

Signal Transduction and Targeted Therapy, Journal Year: 2020, Volume and Issue: 5(1)

Published: Oct. 7, 2020

Abstract Nicotinamide adenine dinucleotide phosphate (NADPH) is an essential electron donor in all organisms, and provides the reducing power for anabolic reactions redox balance. NADPH homeostasis regulated by varied signaling pathways several metabolic enzymes that undergo adaptive alteration cancer cells. The reprogramming of renders cells both highly dependent on this network antioxidant capacity more susceptible to oxidative stress. Modulating unique might be effective strategy eliminate these In review, we summarize current existing literatures homeostasis, including its biological functions, regulatory mechanisms corresponding therapeutic interventions human cancers, providing insights into implications targeting metabolism associated mechanism therapy.

Language: Английский

---

Vitamin B₁₂, folate, and the methionine remethylation cycle—biochemistry, pathways, and regulation

Journal of Inherited Metabolic Disease, Journal Year: 2019, Volume and Issue: 42(4), P. 673 - 685

Published: Jan. 28, 2019

Abstract Vitamin B 12 (cobalamin, Cbl) is a nutrient essential to human health. Due its complex structure and dual cofactor forms, Cbl undergoes complicated series of absorptive processing steps before serving as for the enzymes methylmalonyl‐CoA mutase methionine synthase. Methylmalonyl‐CoA required catabolism certain (branched‐chain) amino acids into an anaplerotic substrate in mitochondrion, dysfunction enzyme itself or production adenosyl‐Cbl result inability successfully undergo protein with concomitant mitochondrial energy disruption. Methionine synthase catalyzes methyl‐Cbl dependent (re)methylation homocysteine within cycle; reaction produce this acid generate S‐adenosylmethionine, most important cellular methyl‐donor. Disruption has wide‐ranging implications all methylation‐dependent reactions, including epigenetic modification, but also intracellular folate pathway, since uses 5‐methyltetrahydrofolate one‐carbon donor. Folate‐bound units are deoxythymidine monophosphate de novo purine synthesis; therefore, flow single carbon each these pathways must be regulated based on needs. This review provides overview metabolism brief description absorption metabolic pathways. It folate‐mediated intersection at cycle. Finally, summary recent advances understanding how both presented.

Language: Английский

---

The Reactive Species Interactome: Evolutionary Emergence, Biological Significance, and Opportunities for Redox Metabolomics and Personalized Medicine

Antioxidants and Redox Signaling, Journal Year: 2017, Volume and Issue: 27(10), P. 684 - 712

Published: April 11, 2017

Significance: Oxidative stress is thought to account for aberrant redox homeostasis and contribute aging disease. However, more often than not, administration of antioxidants ineffective, suggesting that our current understanding the underlying regulatory processes incomplete. Recent Advances: Similar reactive oxygen species nitrogen species, sulfur are now emerging as important signaling molecules, targeting cysteine switches in proteins, affecting gene regulation, ion transport, intermediary metabolism, mitochondrial function. To rationalize complexity chemical interactions with themselves their targets help define role systemic metabolic control, we here introduce a novel integrative concept defined interactome (RSI). The RSI primeval multilevel system whose architecture, together physicochemical characteristics its constituents, allows efficient sensing rapid adaptation environmental changes various other stressors enhance fitness resilience at local whole-organism level. Critical Issues: better characterize RSI-related determine fluxes through specific pathways enable integration, it necessary disentangle biology activity (including precursors reaction products), targets, communication systems, effects on cellular, organ, bioenergetics using system-level/network analyses. Future Directions: Understanding mechanisms which operates will appreciation possibilities modulate entire biological system; moreover, unveiling molecular signatures challenges or forms provide new prevention/intervention opportunities personalized medicine. Antioxid. Redox Signal. 00, 000–000.

Language: Английский

---

Mammals divert endogenous genotoxic formaldehyde into one-carbon metabolism

Nature, Journal Year: 2017, Volume and Issue: 548(7669), P. 549 - 554

Published: Aug. 15, 2017

Language: Английский

---

NADPH production by the oxidative pentose-phosphate pathway supports folate metabolism

Nature Metabolism, Journal Year: 2019, Volume and Issue: 1(3), P. 404 - 415

Published: March 11, 2019

Language: Английский

---