Oxidative Medicine and Cellular Longevity,
Journal Year:
2018,
Volume and Issue:
2018(1)
Published: Jan. 1, 2018
Hydrogen
sulfide
(H
2
S)
has
emerged
as
a
relevant
signaling
molecule
in
physiology,
taking
its
seat
bona
fide
gasotransmitter
akin
to
nitric
oxide
(NO)
and
carbon
monoxide
(CO).
After
being
merely
regarded
toxic
poisonous
molecule,
it
is
now
recognized
that
mammalian
cells
are
equipped
with
sophisticated
enzymatic
systems
for
H
S
production
breakdown.
The
role
of
mainly
related
ability
modify
different
protein
targets,
particularly
by
promoting
persulfidation
cysteine
residues
interacting
metal
centers,
mostly
hemes.
been
shown
regulate
myriad
cellular
processes
multiple
physiological
consequences.
As
such,
dysfunctional
metabolism
increasingly
implicated
pathologies,
from
cardiovascular
neurodegenerative
diseases
cancer.
highly
diffusible
reactive
species,
the
intra‐
extracellular
levels
have
be
kept
under
tight
control
and,
accordingly,
regulation
occurs
at
levels.
Interestingly,
even
though
S,
NO,
CO
similar
modes
action
parallel
regulatory
targets
or
precisely
because
that,
there
increasing
evidence
crosstalk
between
three
gasotransmitters.
Herein
reviewed
biochemistry,
metabolism,
function
hydrogen
sulfide,
well
interplay
other
gasotransmitters,
NO
CO.
Physiological Reviews,
Journal Year:
2022,
Volume and Issue:
103(1), P. 31 - 276
Published: April 18, 2022
Over
the
last
two
decades,
hydrogen
sulfide
(H2S)
has
emerged
as
an
endogenous
regulator
of
a
broad
range
physiological
functions.
H2S
belongs
to
class
molecules
known
gasotransmitters,
which
typically
include
nitric
oxide
(NO)
and
carbon
monoxide
(CO).
Three
enzymes
are
recognized
sources
in
various
cells
tissues:
cystathionine
γ-lyase
(CSE),
β-synthase
(CBS),
3-mercaptopyruvate
sulfurtransferase
(3-MST).
The
present
article
reviews
regulation
these
well
pathways
their
enzymatic
nonenzymatic
degradation
elimination.
multiple
interactions
with
other
labile
(e.g.,
NO)
reactive
oxygen
species
also
outlined.
Next,
biological
targets
signaling
outlined,
special
reference
or
oxidative
posttranscriptional
modification
(persulfidation
sulfhydration)
proteins
effect
on
channels
intracellular
second
messenger
pathways,
gene
transcription
translation,
cellular
bioenergetics
metabolism.
pharmacological
molecular
tools
currently
available
study
physiology
reviewed,
including
utility
limitations.
In
subsequent
sections,
role
functions
is
membrane
potential,
endo-
exocytosis,
cell
organelles
(endoplasmic
reticulum,
Golgi,
mitochondria),
movement,
cycle,
differentiation,
aspects
regulated
death.
roles
types
organ
systems
overviewed,
red
blood
cells,
immune
central
peripheral
nervous
(with
focus
neuronal
transmission,
learning,
memory
formation),
vascular
function
(including
angiogenesis
its
specialized
cerebrovascular,
renal,
pulmonary
beds)
senses,
vision,
hearing,
taste
smell,
pain-sensing.
Finally,
(lung,
heart,
liver,
kidney,
urogenital
organs,
reproductive
system,
bone
cartilage,
skeletal
muscle,
endocrine
organs)
presented,
aging)
but
extending
some
common
pathophysiological
conditions.
From
data,
wide
array
significant
all
emerges
characteristic
bell-shaped
biphasic
effects
highlighted.
addition,
key
aspects,
debated
areas,
future
research
translational
areas
identified.
Trends in Molecular Medicine,
Journal Year:
2020,
Volume and Issue:
26(11), P. 1034 - 1046
Published: June 30, 2020
Inflammatory
bowel
disease
(IBD)
is
associated
with
the
production
of
reactive
species
that
target
cysteine
redox
switches
in
proteins,
thereby
affecting
gene
regulation,
DNA
damage,
ion
transport,
intermediary
metabolism,
and
mitochondrial
function.
Precursors
are
derived
from
organic
inorganic
compounds
their
cofactors,
including
amino
acids,
vitamins,
oxygen,
nitrite,
sulfate.
Nutrition
gut
microbiome
fuel
this
process
to
a
significant
extent.
The
IBD
reflected
by
reduction
systemic
free
thiols,
major
components
antioxidant
machinery.
Systemic
thiols
amenable
nutritional
or
therapeutic
intervention.
This
opens
up
future
avenues
for
modulation
status
IBD.
Pharmacological Research,
Journal Year:
2020,
Volume and Issue:
161, P. 105119 - 105119
Published: Aug. 8, 2020
Hydrogen
sulfide
(H2S)
is
now
recognized
as
an
endogenous
signaling
gasotransmitter
in
mammals.
It
produced
by
mammalian
cells
and
tissues
various
enzymes
-
predominantly
cystathionine
β-synthase
(CBS),
γ-lyase
(CSE)
3-mercaptopyruvate
sulfurtransferase
(3-MST)
but
part
of
the
H2S
intestinal
microbiota
(colonic
H2S-producing
bacteria).
Here
we
summarize
available
information
on
production
functional
role
cell
types
typically
associated
with
innate
immunity
(neutrophils,
macrophages,
dendritic
cells,
natural
killer
mast
basophils,
eosinophils)
adaptive
(T
B
lymphocytes)
under
normal
conditions
it
relates
to
development
inflammatory
immune
diseases.
Special
attention
paid
physiological
pathophysiological
aspects
oral
cavity
colon,
where
parenchymal
are
exposed
a
special
"H2S
environment"
due
bacterial
production.
has
many
cellular
molecular
targets.
Immune
"surrounded"
"cloud"
H2S,
result
exogenous
from
surrounding
which,
turn,
importantly
regulates
their
viability
function.
Downregulation
producing
diseases,
or
genetic
defects
biosynthetic
enzyme
systems
either
lead
spontaneous
autoimmune
disease
accelerate
onset
worsen
severity
immune-mediated
diseases
(e.g.
rheumatoid
arthritis
asthma).
Low,
regulated
amounts
when
therapeutically
delivered
small
molecule
donors,
improve
function
protect
them
against
dysfunction
induced
noxious
stimuli
reactive
oxygen
species
oxidized
LDL).
These
effects
contribute
maintenance
functions,
can
stimulate
antimicrobial
defenses
exert
anti-inflammatory
therapeutic
Oxidative Medicine and Cellular Longevity,
Journal Year:
2018,
Volume and Issue:
2018(1)
Published: Jan. 1, 2018
Exposure
to
UV
light
triggers
the
rapid
generation
and
accumulation
of
reactive
oxygen
species
(ROS)
in
skin
cells,
with
consequent
increase
oxidative
stress
thus
photoaging.
Exogenous
supplementation
dietary
antioxidants
and/or
pretreatment
antioxidant-based
lotions
before
sun
exposure
might
be
a
winning
strategy
against
age-related
pathologies.
In
this
context,
plants
produce
many
secondary
metabolites
protect
themselves
from
radiations
these
compounds
can
also
Phenolic
compounds,
ascorbic
acid
carotenoids,
derived
different
plant
species,
are
able
by
preventing
penetration,
reducing
inflammation
stress,
influencing
several
survival
signalling
pathways.
review,
we
focus
our
attention
on
double
role
oxidants
cell
metabolism
environmental
xenobiotic
agents
involved
Moreover,
discuss
protective
fruits
vegetables
report
their
antiaging
properties
related
reduction
Redox Biology,
Journal Year:
2021,
Volume and Issue:
41, P. 101867 - 101867
Published: Jan. 20, 2021
In
the
open
metabolic
system,
redox-related
signaling
requires
continuous
monitoring
and
fine-tuning
of
steady-state
redox
set
point.
The
ongoing
oxidative
metabolism
is
a
persistent
challenge,
denoted
as
eustress,
which
operates
within
physiological
range
that
has
been
called
'Homeodynamic
Space',
'Goldilocks
Zone'
or
'Golden
Mean'.
Spatiotemporal
control
achieved
by
compartmentalized
generation
removal
oxidants.
cellular
landscape
H2O2,
major
molecule,
characterized
orders-of-magnitude
concentration
differences
between
organelles.
This
pattern
mirrored
oxidatively
modified
proteins,
exemplified
S-glutathionylated
proteins.
review
presents
conceptual
background
for
short-term
(non-transcriptional)
longer-term
(transcriptional/translational)
homeostatic
mechanisms
stress
responses.
point
variable
moving
target
value,
modulated
circadian
rhythm
external
influence,
summarily
exposome,
includes
nutrition
lifestyle
factors.
Emerging
fields
cell-specific
tissue-specific
regulation
in
settings
are
briefly
presented,
including
new
insight
into
role
eustress
embryonal
development
lifespan,
skeletal
muscle
exercise,
sleep-wake
rhythm,
function
nervous
system
with
aspects
leading
to
psychobiology.
