The oral–gut microbiome axis in health and disease

Nature Reviews Microbiology, Journal Year: 2024, Volume and Issue: 22(12), P. 791 - 805

Published: July 22, 2024

Language: Английский

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Roles of microbiota in pancreatic cancer development and treatment

Gut Microbes, Journal Year: 2024, Volume and Issue: 16(1)

Published: Feb. 27, 2024

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease with poor prognosis. This due to the fact that most cases are only diagnosed at advanced and palliative stage, there a high incidence of therapy resistance. Despite ongoing efforts, date, mechanisms underlying PDAC oncogenesis its responses treatment still largely unclear. As study microbiome in cancer progresses, growing evidence suggests bacteria or fungi might be key players both as well resistance chemo- immunotherapy, for instance through modulation tumor microenvironment reshaping host immune response. Here, we review how microbiota exerts these effects directly indirectly via microbial-derived metabolites. Finally, further discuss potential modulating composition PDAC.

Language: Английский

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Liver–Microbiome Axis in Health and Disease

Trends in Immunology, Journal Year: 2018, Volume and Issue: 39(9), P. 712 - 723

Published: May 26, 2018

Language: Английский

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Long-term instability of the intestinal microbiome is associated with metabolic liver disease, low microbiota diversity, diabetes mellitus and impaired exocrine pancreatic function

Gut, Journal Year: 2020, Volume and Issue: 70(3), P. 522 - 530

Published: Nov. 9, 2020

The intestinal microbiome affects the prevalence and pathophysiology of a variety diseases ranging from inflammation to cancer. A reduced taxonomic or functional diversity was often observed in association with poorer health outcomes disease general. Conversely, factors manifest that determine long-term stability instability are largely unknown. We aimed identify disease-relevant phenotypes associated faecal microbiota (in-)stability.A total 2564 paired samples 1282 participants population-based Study Health Pomerania (SHIP) were collected at 5-year (median) interval profiles determined by 16S rRNA gene sequencing. changes over time highly standardised comprehensive phenotypic data related (in-)stability.The overall landscape remained remarkably stable time. greatest contributing metabolic syndrome such as fatty liver diabetes mellitus. These, turn, an increase facultative pathogens Enterobacteriaceae Escherichia/Shigella. Greatest higher initial alpha diversity, female sex, high household income preserved exocrine pancreatic function. Participants who newly developed during follow-up already displayed significant study entry when absent.This identifies distinct components be microbiome, increased abundance thus greater susceptibility toward dysbiosis-associated diseases.

Language: Английский

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The Gut Microbiome in Pancreatic Disease

Clinical Gastroenterology and Hepatology, Journal Year: 2018, Volume and Issue: 17(2), P. 290 - 295

Published: Aug. 23, 2018

Language: Английский

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Impaired Exocrine Pancreatic Function Associates With Changes in Intestinal Microbiota Composition and Diversity

Gastroenterology, Journal Year: 2018, Volume and Issue: 156(4), P. 1010 - 1015

Published: Nov. 2, 2018

Language: Английский

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Probiotics, Nutrition, and the Small Intestine

Current Gastroenterology Reports, Journal Year: 2020, Volume and Issue: 22(1)

Published: Jan. 1, 2020

Abstract Purpose of Review Probiotics are promising remedial treatments for symptoms small intestine (SI) diseases and promoters overall good health. play an important role in supporting a healthy SI microbiome (eubiosis), preventing establishment unhealthy microbiota. eubiosis promotes optimal nutrient uptake, nutritional status maintains SI, reducing the likelihood diseases. It is to understand advantages limitations probiotic therapies. Recent Findings Microbial dysbiosis decreases capacity bowel utilize absorb dietary compounds. In some studies, supplements containing lactic acid bacteria Bifidobacterium have been demonstrated effective beneficial microbes while improving barrier integrity malabsorption disease-related pathology. Summary Strain-specific therapy may be natural approach restoring eubiosis, resulting improved absorption better health, including incidence severity

Language: Английский

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The Orai Ca²⁺ channel inhibitor CM4620 targets both parenchymal and immune cells to reduce inflammation in experimental acute pancreatitis

The Journal of Physiology, Journal Year: 2019, Volume and Issue: 597(12), P. 3085 - 3105

Published: May 3, 2019

This work confirms previous reports that CM4620, a small molecule inhibitor of Ca

Language: Английский

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CRAC channels as targets for drug discovery and development

Cell Calcium, Journal Year: 2018, Volume and Issue: 74, P. 147 - 159

Published: July 18, 2018

Language: Английский

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Characterization of intestinal microbiota in alcoholic patients with and without alcoholic hepatitis or chronic alcoholic pancreatitis

Scientific Reports, Journal Year: 2018, Volume and Issue: 8(1)

Published: March 13, 2018

Excessive alcohol consumption leads to severe alcoholic hepatitis (sAH) or chronic pancreatitis (CAP) only in a subset of patients. We aimed characterize the intestinal microbiota profiles patients according presence and nature complications observed: sAH CAP. Eighty two were included their complications: CAP (N = 24), 13) no (alcoholic controls, AC, N 45). analyzed by high-throughput sequencing. Bacterial diversity was lower with CAP, who had global composition different from that AC. The these groups differed for 17 genera, eight which more frequent (e.g. Klebsiella, Enterococcus Sphingomonas). There significant difference bacterial between groups. However, 16 taxa patients, 10 After adjustment confounding factors found have higher levels Haemophilus. For specific signatures are associated complications. Patients also display dysbiosis relative

Language: Английский

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