Metabolic Coordination of Physiological and Pathological Cardiac Remodeling

Circulation Research, Journal Year: 2018, Volume and Issue: 123(1), P. 107 - 128

Published: June 21, 2018

Metabolic pathways integrate to support tissue homeostasis and prompt changes in cell phenotype. In particular, the heart consumes relatively large amounts of substrate not only regenerate ATP for contraction but also sustain biosynthetic reactions replacement cellular building blocks. control intracellular redox state, metabolic intermediates end products provide signals that enzymatic activity gene expression. Mounting evidence suggests cardiac metabolism occur during development, exercise, pregnancy as well with pathological stress (eg, myocardial infarction, pressure overload) are causative remodeling. Metabolism-mediated expression, metabolite signaling, channeling glucose-derived carbon toward anabolic seem critical physiological growth heart, inefficiency loss coordinated emerging proximal causes This review integrates knowledge different forms remodeling develop general models how relationships between catabolic glucose may fortify health or promote (mal)adaptive Adoption conceptual frameworks based relational biology enable further understanding regulates structure function.

Language: Английский

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Next generation probiotics in disease amelioration

Journal of Food and Drug Analysis, Journal Year: 2019, Volume and Issue: 27(3), P. 615 - 622

Published: Feb. 2, 2019

Studies on the role of gut commensal bacteria in health development have rapidly attracted much more attention beyond classical pathogens over last decade. Many important reports highlighted changes microbiota (dysbiosis) are closely related to intra- and extra-intestinal, chronic inflammation diseases such as colitis, obesity/metabolic syndromes, diabetes mellitus, liver diseases, cardiovascular also cancer neurodegenerative diseases. To circumvent these difficulties, strategy modulating structure has been under intensive study shed light amelioration While traditional probiotics generally show marginal ameliorative effects, emerging next generation start reveal new preventive therapeutic tools. Recent studies unraveled many potential (NGP). These include Prevotella copri Christensenella minuta that control insulin resistance, Parabacteroides goldsteinii, Akkermansia muciniphila Bacteroides thetaiotaomicron reverse obesity Faecalibacterium prausnitzii protects mice against intestinal fragilis reduces shows anticancer effect. New agents will soon be revealed for targeted therapy specific The roles normobiosis maintenance integrity homeostasis emphasized.

Language: Английский

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snRNA-seq reveals a subpopulation of adipocytes that regulates thermogenesis

Nature, Journal Year: 2020, Volume and Issue: 587(7832), P. 98 - 102

Published: Oct. 28, 2020

Language: Английский

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A Forward Chemical Genetic Screen Reveals Gut Microbiota Metabolites That Modulate Host Physiology

Cell, Journal Year: 2019, Volume and Issue: 177(5), P. 1217 - 1231.e18

Published: April 18, 2019

Language: Английский

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Role of microbiota-derived short-chain fatty acids in nervous system disorders

Biomedicine & Pharmacotherapy, Journal Year: 2021, Volume and Issue: 139, P. 111661 - 111661

Published: May 8, 2021

During the past decade, accumulating evidence from research highlights suggested effects of bacterial communities human gut microbiota and their metabolites on health disease. In this regard, microbiota-derived receptors, beyond immune system, maintain metabolism homeostasis, which is essential to host's by balancing utilization intake nutrients. It has been shown that dysbiosis can cause pathology altered metabolites' formation, resulting in dysregulation system metabolism. The short-chain fatty acids (SCFAs), such as butyrate, acetate, succinate, are produced due fermentation process bacteria gut. noted remodeling associated with pathophysiology several neurological disorders, Alzheimer's disease, multiple sclerosis, Parkinson's amyotrophic lateral stress, anxiety, depression, autism, vascular dementia, schizophrenia, stroke, neuromyelitis optica spectrum among others. This review will discuss current most significant studies dealing some SCFAs microbial selected disorders.

Language: Английский

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The role of the gut microbiota in development, function and disorders of the central nervous system and the enteric nervous system

Journal of Neuroendocrinology, Journal Year: 2019, Volume and Issue: 31(5)

Published: Jan. 8, 2019

The gut microbiota has emerged as an environmental factor that modulates the development of central nervous system (CNS) and enteric (ENS). Before obtaining its own microbiota, eutherian foetuses are exposed to products metabolites from maternal microbiota. At birth, infants colonised by microorganisms. microbial composition in early life is strongly influenced mode delivery, feeding method, use antibiotics composition. Microbial microbially produced act signalling molecules have direct or indirect effects on CNS ENS. An increasing number studies show can modulate important processes during development, including neurogenesis, myelination, glial cell function, synaptic pruning blood-brain barrier permeability. Furthermore, numerous indicate there a developmental window which crucial perturbation this period causes long-lasting However, other functions readily modulated adult animals, microglia activation neuroinflammation. Several neurobehavioural, neurodegenerative, mental metabolic disorders, Parkinson disease, autism spectrum disorder, schizophrenia, Alzheimer's depression obesity, been linked This review focuses role microorganisms function ENS, well their potential pathogenesis.

Language: Английский

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Gut microbiota-derived succinate: Friend or foe in human metabolic diseases?

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2019, Volume and Issue: 20(4), P. 439 - 447

Published: Oct. 25, 2019

Abstract There is now a wealth of evidence showing that communication between microbiota and the host critical to sustain vital functions healthy host, disruptions this homeostatic coexistence are known be associated with range diseases including obesity type 2 diabetes. Microbiota-derived metabolites act both as nutrients messenger molecules can signal distant organs in body shape pathophysiology. In review, we provide new perspective on succinate gut microbiota-derived metabolite key role governing intestinal homeostasis energy metabolism. Thus, not merely major intermediary TCA traditionally considered an extracellular danger but also by-product some bacteria primary cross-feeding resident microbes. addition maintain microbiome, specific peripheral tissues regulating nutrient metabolism should rule out. Indeed, recent research point probiotic interventions directed modulate levels lumen, microbiota-based therapies treat related co-morbidities. While further essential, large strategic mediator microbiota-host cross-talk, which might basis for therapeutically approaches near future.

Language: Английский

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Regulation of immune responses by tuft cells

Nature reviews. Immunology, Journal Year: 2019, Volume and Issue: 19(9), P. 584 - 593

Published: May 21, 2019

Language: Английский

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Enterochromaffin 5-HT cells – A major target for GLP-1 and gut microbial metabolites

Molecular Metabolism, Journal Year: 2018, Volume and Issue: 11, P. 70 - 83

Published: March 11, 2018

5-HT storing enterochromaffin (EC) cells are believed to respond nutrient and gut microbial components, receptor-expressing afferent vagal neurons have been described be the major sensors of nutrients in GI-tract. However, molecular mechanism through which EC sense microbiota is still unclear. TPH1, generating enzyme, chromogranin A, an acidic protein responsible for secretory granule storage 5-HT, were highly enriched FACS-purified from both small intestine colon using a antibody-based method. Surprisingly, did not express GPCR lipid metabolites, such as FFAR1, GPR119, GPBAR1 (TGR5), CaSR, GPR142, contrast neighboring GLP-1 enteroendocrine cell. receptor was particularly expressed judged by qPCR immunohistochemistry antibody. agonists robustly stimulated secretion intestinal preparations HPLC specific amperometric Colonic many different types known potential metabolites including three receptors SCFAs, i.e. FFAR2, OLF78, OLF558 aromatic acids, GPR35; secondary bile acids GPBAR1; acyl-amides lactate, GPR132. Nutrient apparently do stimulate directly but paracrine involving secreted cells. In contrast, colonic able multitude generated well hormones, GLP-1.

Language: Английский

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An ALOX12–12-HETE–GPR31 signaling axis is a key mediator of hepatic ischemia–reperfusion injury

Nature Medicine, Journal Year: 2017, Volume and Issue: 24(1), P. 73 - 83

Published: Dec. 11, 2017

Language: Английский

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