Effects of Intermittent Fasting on Health, Aging, and Disease

New England Journal of Medicine, Journal Year: 2019, Volume and Issue: 381(26), P. 2541 - 2551

Published: Dec. 25, 2019

Evidence is accumulating that eating in a 6-hour period and fasting for 18 hours can trigger metabolic switch from glucose-based to ketone-based energy, with increased stress resistance, longevity, decreased incidence of diseases, including cancer obesity.

Language: Английский

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Nutrition Therapy for Adults With Diabetes or Prediabetes: A Consensus Report

Diabetes Care, Journal Year: 2019, Volume and Issue: 42(5), P. 731 - 754

Published: April 15, 2019

This Consensus Report is intended to provide clinical professionals with evidencebased guidance about individualizing nutrition therapy for adults diabetes or prediabetes.Strong evidence supports the efficacy and cost-effectiveness of as a component quality care, including its integration into medical management diabetes; therefore, it important that all members health care team know champion benefits key messages.Nutrition counseling works toward improving maintaining glycemic targets, achieving weight goals, cardiovascular risk factors (e.g., blood pressure, lipids, etc.) within individualized treatment goals recommended prediabetes.Though might simplify messaging, "one-size-fits-all" eating plan not evident prevention diabetes, an unrealistic expectation given broad spectrum people affected by prediabetes, their cultural backgrounds, personal preferences, co-occurring conditions (often referred comorbidities), socioeconomic settings in which they live.Research provides clarity on many food choices patterns can help achieve life.The American Diabetes Association (ADA) emphasizes (MNT) fundamental overall plan, need MNT should be reassessed frequently providers collaboration across life span, special attention during times changing status stages (1-3).This now includes information previous ADA position statements, last was published 2014 (4), did not.Unless otherwise noted, research reviewed limited those studies conducted diagnosed type 1 and/or 2 diabetes.Nutrition children women gestational mellitus addressed this review but covered other publications, specifically Standards Medical Care (5,6). DATA SOURCES, SEARCHES, AND STUDY SELECTIONThe authors report were chosen following national call experts ensure diversity both professional interest background, person living who served patient advocate.An outside market company used conduct literature search paid using funds.The convened one group meeting actively participated monthly teleconference calls between February November 2018.Focused calls, email, web-based also reach consensus final recommendations 2018 January 2019.The statement (4) starting point, PubMed English 28 updated interventions nonhospitalized prediabetes diabetes.Details keywords strategy are reported Supplementary Data, emphasizing randomized controlled trials (RCTs), systematic reviews, metaanalyses RCTs.An exception made inclusion criteria use meal insulin dosing section.In addition results, select cases identified relevant include reaching consensus.The

Language: Английский

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Targeting inflammation in atherosclerosis — from experimental insights to the clinic

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(8), P. 589 - 610

Published: May 11, 2021

Language: Английский

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Ten-Hour Time-Restricted Eating Reduces Weight, Blood Pressure, and Atherogenic Lipids in Patients with Metabolic Syndrome

Cell Metabolism, Journal Year: 2019, Volume and Issue: 31(1), P. 92 - 104.e5

Published: Dec. 5, 2019

Language: Английский

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Circadian clocks and insulin resistance

Nature Reviews Endocrinology, Journal Year: 2018, Volume and Issue: 15(2), P. 75 - 89

Published: Dec. 7, 2018

Language: Английский

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Early Time-Restricted Feeding Improves 24-Hour Glucose Levels and Affects Markers of the Circadian Clock, Aging, and Autophagy in Humans

Nutrients, Journal Year: 2019, Volume and Issue: 11(6), P. 1234 - 1234

Published: May 30, 2019

Time-restricted feeding (TRF) is a form of intermittent fasting that involves having longer daily period. Preliminary studies report TRF improves cardiometabolic health in rodents and humans. Here, we performed the first study to determine how affects gene expression, circulating hormones, diurnal patterns risk factors Eleven overweight adults participated 4-day randomized crossover where they ate between 8 am 2 pm (early (eTRF)) (control schedule). Participants underwent continuous glucose monitoring, blood was drawn assess factors, expression whole cells. Relative control schedule, eTRF decreased mean 24-hour levels by 4 ± 1 mg/dl (p = 0.0003) glycemic excursions 12 3 0.001). In morning before breakfast, increased ketones, cholesterol, stress response aging SIRT1 autophagy LC3A (all p < 0.04), while evening, it tended increase brain-derived neurotropic factor (BNDF; 0.10) also MTOR 0.007), major nutrient-sensing protein regulates cell growth. altered cortisol several circadian clock genes 0.05). levels, alters lipid metabolism may have anti-aging effects

Language: Английский

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Molecular mechanisms of dietary restriction promoting health and longevity

Nature Reviews Molecular Cell Biology, Journal Year: 2021, Volume and Issue: 23(1), P. 56 - 73

Published: Sept. 13, 2021

Language: Английский

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Effects of 4- and 6-h Time-Restricted Feeding on Weight and Cardiometabolic Health: A Randomized Controlled Trial in Adults with Obesity

Cell Metabolism, Journal Year: 2020, Volume and Issue: 32(3), P. 366 - 378.e3

Published: July 15, 2020

Language: Английский

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A time to fast

Science, Journal Year: 2018, Volume and Issue: 362(6416), P. 770 - 775

Published: Nov. 15, 2018

Nutrient composition and caloric intake have traditionally been used to devise optimized diets for various phases of life. Adjustment meal size frequency emerged as powerful tools ameliorate postpone the onset disease delay aging, whereas periods fasting, with or without reduced energy intake, can profound health benefits. The underlying physiological processes involve periodic shifts metabolic fuel sources, promotion repair mechanisms, optimization utilization cellular organismal health. Future research endeavors should be directed integration a balanced nutritious diet controlled patterns fasting develop better strategies prevent, postpone, treat socioeconomical burden chronic diseases associated aging.

Language: Английский

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Time‐Restricted Feeding Improves Glucose Tolerance in Men at Risk for Type 2 Diabetes: A Randomized Crossover Trial

Obesity, Journal Year: 2019, Volume and Issue: 27(5), P. 724 - 732

Published: April 19, 2019

Objective This study aimed to assess the effects of 9‐hour time‐restricted feeding (TRF), early (TRFe) or delayed (TRFd), on glucose tolerance in men at risk for type 2 diabetes. Methods Fifteen (age 55 ± 3 years, BMI 33.9 0.8 kg/m ) wore a continuous monitor 7 days baseline assessment and during two 7‐day TRF conditions. Participants were randomized TRFe (8 am 5 pm TRFd (12 9 ), separated by 2‐week washout phase. Glucose, insulin, triglycerides, nonesterified fatty acids, gastrointestinal hormone incremental areas under curve calculated following standard meal 0 8 12 (TRFd). Results improved as assessed reduction area ( P = 0.001) fasting triglycerides 0.003) day versus 0. However, there no mealtime interactions any variables examined. There was also effect postprandial hormones. Mean lower 0.02) but not 0.17) baseline, difference between Conclusions While only lowered mean glucose, glycemic responses test diabetes regardless clock time that initiated.

Language: Английский

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