Effects of Time-Restricted Eating on Weight Loss and Other Metabolic Parameters in Women and Men With Overweight and Obesity

JAMA Internal Medicine, Journal Year: 2020, Volume and Issue: 180(11), P. 1491 - 1491

Published: Sept. 28, 2020

The efficacy and safety of time-restricted eating have not been explored in large randomized clinical trials.

Language: Английский

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Calorie Restriction with or without Time-Restricted Eating in Weight Loss

New England Journal of Medicine, Journal Year: 2022, Volume and Issue: 386(16), P. 1495 - 1504

Published: April 20, 2022

We randomly assigned 139 patients with obesity to time-restricted eating (eating only between 8:00 a.m. and 4:00 p.m.) calorie restriction or daily alone. For 12 months, all the participants were instructed follow a calorie-restricted diet that consisted of 1500 1800 kcal per day for men 1200 women. The primary outcome was difference two groups in change from baseline body weight; secondary outcomes included changes waist circumference, body-mass index (BMI), amount fat, measures metabolic risk factors.

Language: Английский

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Alternate Day Fasting Improves Physiological and Molecular Markers of Aging in Healthy, Non-obese Humans

Cell Metabolism, Journal Year: 2019, Volume and Issue: 30(3), P. 462 - 476.e6

Published: Aug. 27, 2019

Language: Английский

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The role of the gut microbiome and its metabolites in metabolic diseases

Protein & Cell, Journal Year: 2020, Volume and Issue: 12(5), P. 360 - 373

Published: Dec. 21, 2020

Abstract It is well known that an unhealthy lifestyle a major risk factor for metabolic diseases, while in recent years, accumulating evidence has demonstrated the gut microbiome and its metabolites also play crucial role onset development of many including obesity, type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular disease so on. Numerous microorganisms dwell gastrointestinal tract, which key interface energy acquisition can metabolize dietary nutrients into bioactive substances, thus acting as link between host. The shaped by host genetics, immune responses factors. potential determines significance health diseases. Therefore, targeting relevant pathways would be effective therapeutic treatments diseases near future. This review will summarize information about organism metabolism relationship microbiome-derived pathogenesis Furthermore, advances improving regulating discussed.

Language: Английский

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Time-Restricted Eating to Prevent and Manage Chronic Metabolic Diseases

Annual Review of Nutrition, Journal Year: 2019, Volume and Issue: 39(1), P. 291 - 315

Published: June 10, 2019

Molecular clocks are present in almost every cell to anticipate daily recurring and predictable changes, such as rhythmic nutrient availability, adapt cellular functions accordingly. At the same time, nutrient-sensing pathways can respond acute imbalance modulate orient metabolism so cells optimally a declining or increasing availability of nutrients. Organismal circadian rhythms coordinated by behavioral activity-rest feeding-fasting cycles temporally orchestrate sequence physiological processes optimize metabolism. Basic research has largely focused on functioning self-sustaining molecular oscillator, while nutrition science yielded insights into responses caloric deprivation specific macronutrients. Integration these two fields actionable new concepts timing food intake led emerging practice time-restricted eating. In this paradigm, is restricted consistent window 8-12 h. This paradigm pervasive benefits multiple organ systems.

Language: Английский

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Epigenetic regulation of aging: implications for interventions of aging and diseases

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Nov. 7, 2022

Abstract Aging is accompanied by the decline of organismal functions and a series prominent hallmarks, including genetic epigenetic alterations. These aging-associated changes include DNA methylation, histone modification, chromatin remodeling, non-coding RNA (ncRNA) regulation, all which participate in regulation aging process, hence contribute to aging-related diseases. Therefore, understanding mechanisms will provide new avenues develop strategies delay aging. Indeed, interventions based on manipulating have led alleviation or extension lifespan animal models. Small molecule-based therapies reprogramming that enable rejuvenation been developed for ameliorating reversing conditions. In addition, adopting health-promoting activities, such as caloric restriction, exercise, calibrating circadian rhythm, has demonstrated Furthermore, various clinical trials intervention are ongoing, providing more evidence safety efficacy these therapies. Here, we review recent work outline advances age-associated A better critical roles epigenetics process lead prevention human therapy

Language: Английский

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Effectiveness of Intermittent Fasting and Time-Restricted Feeding Compared to Continuous Energy Restriction for Weight Loss

Nutrients, Journal Year: 2019, Volume and Issue: 11(10), P. 2442 - 2442

Published: Oct. 14, 2019

The current obesity epidemic is staggering in terms of its magnitude and public health impact. Current guidelines recommend continuous energy restriction (CER) along with a comprehensive lifestyle intervention as the cornerstone treatment, yet this approach produces modest weight loss on average. Recently, there has been increased interest identifying alternative dietary strategies that involve restricting intake to certain periods day or prolonging fasting interval between meals (i.e., intermittent restriction, IER). These include (IMF; >60% 2-3 days per week, alternate days) time-restricted feeding (TRF; limiting daily period food 8-10 h less most week). Here, we summarize evidence for IER regimens treatments overweight obesity. Specifically, review randomized trials ≥8 weeks duration performed adults (BMI ≥ 25 kg/m2) which an paradigm (IMF TRF) was compared CER, primary outcome being loss. Overall, available suggests paradigms produce equivalent when 9 out 11 studies reviewed showing no differences groups body fat

Language: Английский

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Circadian rhythm as a therapeutic target

Nature Reviews Drug Discovery, Journal Year: 2021, Volume and Issue: 20(4), P. 287 - 307

Published: Feb. 15, 2021

Language: Английский

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Metabolism and Metabolic Disorders and the Microbiome: The Intestinal Microbiota Associated With Obesity, Lipid Metabolism, and Metabolic Health—Pathophysiology and Therapeutic Strategies

Gastroenterology, Journal Year: 2020, Volume and Issue: 160(2), P. 573 - 599

Published: Nov. 27, 2020

Language: Английский

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Lifestyle factors and high-risk atherosclerosis: Pathways and mechanisms beyond traditional risk factors

European Journal of Preventive Cardiology, Journal Year: 2019, Volume and Issue: 27(4), P. 394 - 406

Published: Aug. 13, 2019

Despite major efforts to reduce atherosclerotic cardiovascular disease (ASCVD) burden with conventional risk factor control, significant residual remains. Recent evidence on non-traditional determinants of cardiometabolic health has advanced our understanding lifestyle–disease interactions. Chronic exposure environmental stressors like poor diet quality, sedentarism, ambient air pollution and noise, sleep deprivation psychosocial stress affect numerous traditional intermediary pathways related ASCVD. These include body composition, cardiorespiratory fitness, muscle strength functionality the intestinal microbiome, which are increasingly recognized as health. Evidence points partially overlapping mechanisms, including effects inflammatory nutrient sensing pathways, endocrine signalling, autonomic function autophagy. Of particular relevance is potential low-risk lifestyle factors impact plaque vulnerability through altered adipose tissue skeletal phenotype secretome. Collectively, cause a set phenotypic adaptations shifting cross-talk from proinflammatory milieu conducive for high-risk atherosclerosis an anti-atherogenic milieu. The ketone ß-hydroxybutyrate, inhibition NLRP-3 inflammasome, likely be many these observed benefits. Adhering adds prognostic value optimal management, benefit occurs even when markers discouragingly minimal or not present. aims this review (a) discuss novel their underlying biochemical principles (b) provide new perspectives potentially more feasible recommendations improve long-term adherence factors.

Language: Английский

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