Importance of circadian timing for aging and longevity

Nature Communications, Journal Year: 2021, Volume and Issue: 12(1)

Published: May 17, 2021

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR can be achieved by controlling how much and/or when food is provided, as well adjusting nutritional composition. Because these factors are often combined during DR, it unclear which necessary for beneficial effects. Several drugs have been utilized that target nutrient-sensing gene pathways, many of change expression throughout the day, suggesting timing drug administration critical. Here, we discuss dietary pharmacological interventions promote a healthy lifespan influencing energy intake circadian rhythms.

Language: Английский

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Oxidative phosphorylation as a potential therapeutic target for cancer therapy

International Journal of Cancer, Journal Year: 2019, Volume and Issue: 146(1), P. 10 - 17

Published: Aug. 9, 2019

In contrast to prior belief, cancer cells require oxidative phosphorylation (OXPHOS) strive, and exacerbated OXPHOS dependency frequently characterizes stem cells, as well primary or acquired resistance against chemotherapy tyrosine kinase inhibitors. A growing arsenal of therapeutic agents is being designed suppress the transfer mitochondria from stromal malignant interfere with mitochondrial biogenesis, directly inhibit respiratory chain complexes, disrupt function in other ways. For experimental treatment cancers, inhibitors can be advantageously combined inhibitors, strategies glycolysis, thereby causing a lethal energy crisis. Unfortunately, most preclinical data arguing favor inhibition have been obtained xenograft models, which human are implanted immunodeficient mice. Future studies on should elaborate optimal schedules combination regimens that stimulate—or at least compatible with—anticancer immune responses for long‐term tumor control.

Language: Английский

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Mitochondrial dynamics and transport in Alzheimer's disease

Molecular and Cellular Neuroscience, Journal Year: 2019, Volume and Issue: 98, P. 109 - 120

Published: June 16, 2019

Mitochondrial dysfunction is now recognized as a contributing factor to the early pathology of multiple human conditions including neurodegenerative diseases. Mitochondria are signaling organelles with multitude functions ranging from energy production regulation cellular metabolism, homeostasis, stress response, and cell fate. The success these complex processes critically depends on fidelity mitochondrial dynamics that include ability mitochondria change shape location in cell, which essential for maintenance proper function quality control, particularly polarized cells such neurons. This review highlights several aspects alterations Alzheimer's disease, may contribute etiology this debilitating condition. We also discuss therapeutic strategies improve provide an alternative approach failed amyloid-directed interventions.

Language: Английский

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Resveratrol Modulates the Gut Microbiota and Inflammation to Protect Against Diabetic Nephropathy in Mice

Frontiers in Pharmacology, Journal Year: 2020, Volume and Issue: 11

Published: Aug. 19, 2020

Oral administration of resveratrol is able to ameliorate the progression diabetic nephropathy (DN); however, its mechanisms action remain unclear. Recent evidence suggested that gut microbiota involved in metabolism therapeutics. In current study, we sought determine whether anti-DN effects are mediated through modulation using genetic db/db mouse model DN. We demonstrate treatment mice relieves a series clinical indicators then show improves intestinal barrier function and ameliorates permeability inflammation. The composition microbiome was significantly altered compared control db/m mice. Dysbiosis characterized by low abundance levels Bacteroides, Alistipes, Rikenella, Odoribacter, Parabacteroides, Alloprevotella genera were reversed treatment, suggesting potential role for DN progression. Furthermore, fecal transplantation, derived from healthy resveratrol-treated mice, sufficient antagonize renal dysfunction, rebalance improve inflammation recipient These results indicate resveratrol-mediated changes may play an important mechanism resveratrol, which provides supporting gut-kidney axis

Language: Английский

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Impact of a Ketogenic Diet on Metabolic Parameters in Patients with Obesity or Overweight and with or without Type 2 Diabetes: A Meta-Analysis of Randomized Controlled Trials

Nutrients, Journal Year: 2020, Volume and Issue: 12(7), P. 2005 - 2005

Published: July 6, 2020

The aim of this meta-analysis was to explore the efficacy a ketogenic diet in metabolic control patients with overweight or obesity and without type 2 diabetes. Embase, PubMed, Cochrane Library were searched for randomized controlled trials that enrolled on control. Fourteen studies included meta-analysis. effects diets glycemic greater diabetic relative those low-fat diets, indicated by lower glycated hemoglobin (SMD, -0.62; p < 0.001) homeostatic model assessment index -0.29; = 0.02), while comparable observed nondiabetic patients. Ketogenic led substantial weight reduction -0.46; 0.04) irrespective patients' diabetes status at baseline improved lipid profiles terms triglyceride -0.45; 0.01) high-density lipoprotein 0.31; 0.005) Other risk markers showed no between-group difference post intervention. Our study findings confirmed more effective improving parameters associated glycemic, weight, controls obesity, especially preexisting diabetes, as compared diets. This effect may contribute improvements dysfunction-related morbidity mortality these patient populations.

Language: Английский

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Probiotics, Prebiotics, and Phytogenic Substances for Optimizing Gut Health in Poultry

Microorganisms, Journal Year: 2022, Volume and Issue: 10(2), P. 395 - 395

Published: Feb. 8, 2022

The gut microbiota has been designated as a hidden metabolic 'organ' because of its enormous impact on host metabolism, physiology, nutrition, and immune function. connection between the intestinal their respective animals is dynamic and, in general, mutually beneficial. This complicated interaction seen determinant health disease; thus, dysbiosis linked with several diseases. Therefore, tractable strategies targeting regulation can control diseases that are closely related to inflammatory disorders. As result, animal performance improved. One these dietary supplementation prebiotics, probiotics, phytogenic substances. These supplements exert effects indirectly through manipulation quality improvement epithelial barrier. Several substances, such berberine, resveratrol, curcumin, carvacrol, thymol, isoflavones hydrolyzed fibers, have identified potential may also act welcome means reduce usage antibiotics feedstock, including poultry farming, microbiome. In addition, compounds improve integrity tight junctions by controlling junction-related proteins signaling pathways animals. this review, we discuss role substances optimizing function poultry.

Language: Английский

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Adipose tissue aging: mechanisms and therapeutic implications

Cell Death and Disease, Journal Year: 2022, Volume and Issue: 13(4)

Published: April 4, 2022

Abstract Adipose tissue, which is the crucial energy reservoir and endocrine organ for maintenance of systemic glucose, lipid, homeostasis, undergoes significant changes during aging. These cause physiological declines age-related disease in elderly population. Here, we review adipose tissue at multiple levels highlight underlying mechanisms regulating aging process. We also discuss pathogenic pathways fat dysfunctions their negative consequences, such as dyslipidemia, chronic general inflammation, insulin resistance, type 2 diabetes (T2D). Age-related involve redistribution deposits composition, parallel with functional decline adipocyte progenitors accumulation senescent cells. Multiple induce defective adipogenesis, aberrant adipocytokine production, leading to dysfunction. Changes gene expression extracellular signaling molecules regulate process through various pathways. In addition, impacts other organs that are infiltrated by lipids, leads metabolic system disruption, acceleration. Moreover, studies have indicated an early onset event a potential target extend lifespan. Together, suggest plays key role therapeutic treatment disease, deserves further study advance relevant knowledge.

Language: Английский

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AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

Molecular Cell, Journal Year: 2020, Volume and Issue: 77(5), P. 951 - 969.e9

Published: Jan. 28, 2020

Language: Английский

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Nicotinamide for the treatment of heart failure with preserved ejection fraction

Science Translational Medicine, Journal Year: 2021, Volume and Issue: 13(580)

Published: Feb. 10, 2021

The NAD + precursor nicotinamide improves diastolic dysfunction caused by aging, hypertension, or metabolic syndrome in rodents.

Language: Английский

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The ups and downs of caloric restriction and fasting: from molecular effects to clinical application

EMBO Molecular Medicine, Journal Year: 2021, Volume and Issue: 14(1)

Published: Nov. 15, 2021

Language: Английский

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