Military Medical Research,
Journal Year:
2023,
Volume and Issue:
10(1)
Published: Jan. 3, 2023
Abstract
Obesity
is
one
of
the
most
serious
global
health
problems,
with
an
incidence
that
increases
yearly
and
coincides
development
cancer.
Adipose
tissue
macrophages
(ATMs)
are
particularly
important
in
this
context
contribute
to
linking
obesity-related
inflammation
tumor
progression.
However,
functions
ATMs
on
progression
obesity-associated
cancer
remain
unclear.
In
review,
we
describe
origins,
phenotypes,
ATMs.
Subsequently,
summarize
potential
mechanisms
reprogramming
microenvironment,
including
direct
exchange
dysfunctional
metabolites,
inordinate
cytokines
other
signaling
mediators,
transfer
extracellular
vesicle
cargo,
variations
gut
microbiota
its
metabolites.
A
better
understanding
properties
under
conditions
obesity
will
lead
new
therapeutic
interventions
for
Cell Metabolism,
Journal Year:
2021,
Volume and Issue:
33(9), P. 1869 - 1882.e6
Published: Aug. 10, 2021
The
contribution
of
cellular
heterogeneity
and
architecture
to
white
adipose
tissue
(WAT)
function
is
poorly
understood.
Herein,
we
combined
spatially
resolved
transcriptional
profiling
with
single-cell
RNA
sequencing
image
analyses
map
human
WAT
composition
structure.
This
identified
18
cell
classes
unique
propensities
form
organized
homo-
heterotypic
clusters.
Of
these,
three
constituted
mature
adipocytes
that
were
similar
in
size,
but
distinct
their
spatial
arrangements
profiles.
Based
on
marker
genes,
termed
these
AdipoLEP,
AdipoPLIN,
AdipoSAA.
We
confirmed,
independent
datasets,
respective
gene
profiles
associated
differently
both
adipocyte
whole-body
insulin
sensitivity.
Corroborating
our
observations,
stimulation
vivo
by
hyperinsulinemic-euglycemic
clamp
showed
only
AdipoPLIN
displayed
a
response
insulin.
Altogether,
mining
this
multimodal
resource
identify
composed
adipocytes,
one
which
responsive.
Frontiers in Immunology,
Journal Year:
2021,
Volume and Issue:
12
Published: March 8, 2021
Tissue-resident
macrophages
(TRMs)
are
heterogeneous
populations
originating
either
from
monocytes
or
embryonic
progenitors,
and
distribute
in
lymphoid
non-lymphoid
tissues.
TRMs
play
diverse
roles
many
physiological
processes,
including
metabolic
function,
clearance
of
cellular
debris,
tissue
remodeling
defense.
Macrophages
can
be
polarized
to
different
functional
phenotypes
depending
on
their
origin
microenvironment.
Specific
macrophage
subpopulations
associated
with
disease
progression.
In
studies
fate-mapping
single-cell
RNA
sequencing
methodologies,
several
critical
molecules
have
been
identified
induce
the
change
function.
These
potential
markers
for
diagnosis
selective
targets
novel
macrophage-mediated
treatment.
this
review,
we
discuss
some
recent
findings
regarding
less-known
new
functions
well-known
molecules.
Understanding
mechanisms
these
has
yield
treatments
diagnostic
approaches
disease.
Angiogenesis,
Journal Year:
2022,
Volume and Issue:
25(4), P. 439 - 453
Published: July 20, 2022
Abstract
While
most
tissues
exhibit
their
greatest
growth
during
development,
adipose
tissue
is
capable
of
additional
massive
expansion
in
adults.
Adipose
expandability
advantageous
when
temporarily
storing
fuel
for
use
fasting,
but
becomes
pathological
upon
continuous
food
intake,
leading
to
obesity
and
its
many
comorbidities.
The
dense
vasculature
provides
necessary
oxygen
nutrients,
supports
delivery
from
adipocytes
under
fed
or
fasting
conditions.
Moreover,
the
comprises
a
major
niche
multipotent
progenitor
cells,
which
give
rise
new
are
repair.
Given
multiple,
pivotal
roles
vasculature,
impairments
angiogenic
capacity
may
underlie
obesity-associated
diseases
such
as
diabetes
cardiometabolic
disease.
Exciting
studies
on
single-cell
single-nuclei
composition
mouse
humans
providing
insights
into
mechanisms
angiogenesis.
modes
intercellular
communication
involving
micro
vesicle
exosome
transfer
proteins,
nucleic
acids
organelles
also
being
recognized
play
key
roles.
This
review
focuses
cellular
signaling
underlying
angiogenesis,
impact
pathophysiological
consequences.
