Nature, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 12, 2025
Language: Английский
Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 19(11), P. 655 - 670
Published: Sept. 11, 2023
Language: Английский
Citations
41
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: May 17, 2024
Abstract The liver gene expression of the peroxisomal β-oxidation enzyme acyl-coenzyme A oxidase 1 (ACOX1), which catabolizes very long chain fatty acids (VLCFA), increases in context obesity, but how this pathway impacts systemic energy metabolism remains unknown. Here, we show that hepatic ACOX1-mediated regulates inter-organ communication involved metabolic homeostasis. Liver-specific knockout Acox1 ( -LKO) protects mice from diet-induced adipose tissue inflammation, and insulin resistance. Serum -LKO promotes browning cultured white adipocytes. Global serum lipidomics increased circulating levels several species ω−3 VLCFAs (C24-C28) with previously uncharacterized physiological role promote browning, mitochondrial biogenesis Glut4 translocation through activation lipid sensor GPR120 This work identifies as an important regulator homeostasis suggests manipulation ACOX1 or its substrates may treat obesity-associated disorders.
Language: Английский
Citations
21
Nature Metabolism, Journal Year: 2024, Volume and Issue: 6(5), P. 793 - 807
Published: May 23, 2024
Language: Английский
Citations
18
Nature reviews. Immunology, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 7, 2024
Language: Английский
Citations
18
Nature Reviews Endocrinology, Journal Year: 2023, Volume and Issue: 20(1), P. 50 - 61
Published: Oct. 23, 2023
Language: Английский
Citations
22
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: June 19, 2024
Fibroblast growth factors (FGFs) are a versatile family of peptide that involved in various biological functions, including cell and differentiation, embryonic development, angiogenesis, metabolism. Abnormal FGF/FGF receptor (FGFR) signaling has been implicated the pathogenesis multiple diseases such as cancer, metabolic diseases, inflammatory diseases. It is worth noting macrophage polarization, which involves distinct functional phenotypes, plays crucial role tissue repair, homeostasis maintenance, immune responses. Recent evidence suggests FGF/FGFR closely participates polarization macrophages, indicating they could be potential targets for therapeutic manipulation associated with dysfunctional macrophages. In this article, we provide an overview structure, function, downstream regulatory pathways FGFs, well crosstalk between FGF polarization. Additionally, summarize application harnessing to modulate
Language: Английский
Citations
12
Diabetology & Metabolic Syndrome, Journal Year: 2025, Volume and Issue: 17(1)
Published: Jan. 17, 2025
As cardiovascular disease (CVD) morbidity and mortality increase yearly, this study aimed to explore the potential of weight-adjusted-waist index (WWI) its relation long-term in patients with CVD. The diagnosis CVD was based on standardized medical condition questionnaires that incorporated participants' self-reported physician diagnoses. WWI (cm/√kg) is a continuous variable calculated as waist circumference (WC, cm) divided by square root body weight (kg). For analysis purposes, participants were into four groups quartiles (Q1 - Q4) WWI. study's primary outcome all-cause CVD, secondary outcome, sample weights complex survey designs used ensure reliable, accurate results. final included 4,445 participants. In fully adjusted model, highest quartile (WWI > 12.05 cm/√ kg) showed higher rate compared lowest < 11.03 (HR = 1.37, 95% CI: 1.03, 1.82, P 0.05). risk increased linear association congestive heart failure, attack (P-overall 0.05, nonlinear 0.05); nonlinearly associated coronary angina Survival curve further all cause high group (Q4) (P 0.001). time-dependent receiver operating characteristic (ROC) WWI's area under curves (AUC) for 5- 10-year survival rates 0.76 0.792 0.734 0.757 mortality. AUC than those mass (BMI) WC (all 0.01). Our findings indicate positively an Additionally, values strengthen meaningful prognostic marker, underscoring utility clinical practice assessing
Language: Английский
Citations
1
Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Feb. 18, 2025
Language: Английский
Citations
1
Signal Transduction and Targeted Therapy, Journal Year: 2025, Volume and Issue: 10(1)
Published: March 7, 2025
Abstract Macrophages are immune cells belonging to the mononuclear phagocyte system. They play crucial roles in defense, surveillance, and homeostasis. This review systematically discusses types of hematopoietic progenitors that give rise macrophages, including primitive progenitors, erythro-myeloid stem cells. These have distinct genetic backgrounds developmental processes. Accordingly, macrophages exhibit complex diverse functions body, phagocytosis clearance cellular debris, antigen presentation, response, regulation inflammation cytokine production, tissue remodeling repair, multi-level regulatory signaling pathways/crosstalk involved homeostasis physiology. Besides, tumor-associated a key component TME, exhibiting both anti-tumor pro-tumor properties. Furthermore, functional status is closely linked development various diseases, cancer, autoimmune disorders, cardiovascular disease, neurodegenerative metabolic conditions, trauma. Targeting has emerged as promising therapeutic strategy these contexts. Clinical trials macrophage-based targeted drugs, immunotherapies, nanoparticle-based therapy were comprehensively summarized. Potential challenges future directions targeting also been discussed. Overall, our highlights significance this versatile cell human health which expected inform research clinical practice.
Language: Английский
Citations
1
Nature Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: April 11, 2025
Language: Английский
Citations
1